TUBB1mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia

ACTN1 Mutations Cause Congenital Macrothrombocytopenia

(2013) Shinji Kunishima et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42

(2013) I. Pleines et al.   BLOOD

Does size matter in platelet production?

(2012) J. N. Thon et al.   BLOOD

Inherited platelet disorders

(2012) A. T. NURDEN et al.   HAEMOPHILIA

Genetics of familial forms of thrombocytopenia

(2012) Carlo L. Balduini et al.   HUMAN GENETICS

Microtubule and cortical forces determine platelet size during vascular platelet production

(2012) Jonathan N Thon et al.   Nature Communications

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the  IIb 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

(2011) S. Kunishima et al.   BLOOD

Megakaryocyte lineage-specific class VI β-tubulin suppresses microtubule dynamics, fragments microtubules, and blocks cell division

(2011) Hailing Yang et al.   Cytoskeleton

Cytoskeletal mechanics of proplatelet maturation and platelet release

(2010) Jonathan N. Thon et al.   JOURNAL OF CELL BIOLOGY

Mutation of the  1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly

(2008) S. Kunishima et al.   BLOOD

Visualization of microtubule growth in living platelets reveals a dynamic marginal band with multiple microtubules

(2008) S. Patel-Hett et al.   BLOOD

Mutation inβ1-TubulinCorrelates with Macrothrombocytopenia in Cavalier King Charles Spaniels

(2008) B. Davis et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE