Rac3 regulates breast cancer invasion and metastasis by controlling adhesion and matrix degradation

Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells

(2017) Brian J. Rosenberg et al.   MOLECULAR BIOLOGY OF THE CELL

Tumor Cell Invadopodia: Invasive Protrusions that Orchestrate Metastasis

(2017) Robert J. Eddy et al.   TRENDS IN CELL BIOLOGY

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

(2016) Antonio Castro-Castro et al.   Annual Review of Cell and Developmental Biology

A new front in cell invasion: The invadopodial membrane

(2016) Eric L. Hastie et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Optical Tools To Study the Isoform-Specific Roles of Small GTPases in Immune Cells

(2016) Veronika Miskolci et al.   JOURNAL OF IMMUNOLOGY

Bright monomeric near-infrared fluorescent proteins as tags and biosensors for multiscale imaging

(2016) Daria M. Shcherbakova et al.   Nature Communications

Spatiotemporal analysis of RhoA/B/C activation in primary human endothelial cells

(2016) Nathalie R. Reinhard et al.   Scientific Reports

Kindlin-2 cooperates with talin to activate integrins and induces cell spreading by directly binding paxillin

(2016) Marina Theodosiou et al.   eLife

MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma

(2015) Lizandra Jimenez et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

Synonymous modification results in high-fidelity gene expression of repetitive protein and nucleotide sequences

(2015) Bin Wu et al.   GENES & DEVELOPMENT

DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior

(2015) Maria S. Ioannou et al.   JOURNAL OF CELL BIOLOGY

ARF6–JIP3/4 regulate endosomal tubules for MT1-MMP exocytosis in cancer invasion

(2015) Valentina Marchesin et al.   JOURNAL OF CELL BIOLOGY

Digging a little deeper: The stages of invadopodium formation and maturation

(2014) Brian T. Beaty et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination

(2014) Emanuela Frittoli et al.   JOURNAL OF CELL BIOLOGY

ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo

(2014) Elliott J. Hagedorn et al.   JOURNAL OF CELL BIOLOGY

A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly

(2014) Yasmin Moshfegh et al.   NATURE CELL BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Invadopodia in context

(2014) Aviv Bergman et al.   Cell Adhesion & Migration

Invadopodia and basement membrane invasion in vivo

(2014) Lauren L Lohmer et al.   Cell Adhesion & Migration

Identification of Novel Integrin Binding Partners for Calcium and Integrin Binding Protein 1 (CIB1): Structural and Thermodynamic Basis of CIB1 Promiscuity

(2013) Thomas C. Freeman et al.   BIOCHEMISTRY

Rac3 induces a molecular pathway triggering breast cancer cell aggressiveness: differences in MDA-MB-231 and MCF-7 breast cancer cell lines

(2013) Caroline Gest et al.   BMC CANCER

Endosomal WASH and exocyst complexes control exocytosis of MT1-MMP at invadopodia

(2013) Pedro Monteiro et al.   JOURNAL OF CELL BIOLOGY

Spatial regulation of RhoC activity defines protrusion formation in migrating cells

(2013) J. J. Bravo-Cordero et al.   JOURNAL OF CELL SCIENCE

Signaling inputs to invadopodia and podosomes

(2013) D. Hoshino et al.   JOURNAL OF CELL SCIENCE

Paxillin kinase linker (PKL) regulates Vav2 signaling during cell spreading and migration

(2013) Matthew C. Jones et al.   MOLECULAR BIOLOGY OF THE CELL

β1 integrin regulates Arg to promote invadopodial maturation and matrix degradation

(2013) Brian T. Beaty et al.   MOLECULAR BIOLOGY OF THE CELL

Autocrine HBEGF expression promotes breast cancer intravasation, metastasis and macrophage-independent invasion in vivo

(2013) Z N Zhou et al.   ONCOGENE

Macrophage contact induces RhoA GTPase signaling to trigger tumor cell intravasation

(2013) M Roh-Johnson et al.   ONCOGENE

Invading one step at a time: the role of invadopodia in tumor metastasis

(2013) H Paz et al.   ONCOGENE

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Cell migration and invasion in human disease: the Tks adaptor proteins

(2012) Sara A. Courtneidge   BIOCHEMICAL SOCIETY TRANSACTIONS

Rac1 and Rac3 GTPases Control Synergistically the Development of Cortical and Hippocampal GABAergic Interneurons

(2012) Valentina Vaghi et al.   CEREBRAL CORTEX

N-WASP coordinates the delivery and F-actin–mediated capture of MT1-MMP at invasive pseudopods

(2012) Xinzi Yu et al.   JOURNAL OF CELL BIOLOGY

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

Adhesion rings surround invadopodia and promote maturation

(2012) K. M. Branch et al.   Biology Open

Degrading Devices: Invadosomes in Proteolytic Cell Invasion

(2011) Stefan Linder et al.   Annual Review of Cell and Developmental Biology

Sensing and Modulation of Invadopodia across a Wide Range of Rigidities

(2011) Aron Parekh et al.   BIOPHYSICAL JOURNAL

An EGFR-Src-Arg-Cortactin Pathway Mediates Functional Maturation of Invadopodia and Breast Cancer Cell Invasion

(2011) C. C. Mader et al.   CANCER RESEARCH

A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia

(2011) Jose Javier Bravo-Cordero et al.   CURRENT BIOLOGY

Invadosome regulation by adhesion signaling

(2011) Olivier Destaing et al.   CURRENT OPINION IN CELL BIOLOGY

A Role for Rac3 GTPase in the Regulation of Autophagy

(2011) Wan Long Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway

(2011) Marco A. O. Magalhaes et al.   JOURNAL OF CELL BIOLOGY

Invadopodia: specialized tumor cell structures for the focal degradation of the extracellular matrix

(2009) Roberto Buccione et al.   CANCER AND METASTASIS REVIEWS

Essential role of Rac1 and Rac3 GTPases in neuronal development

(2009) Sara Corbetta et al.   FASEB JOURNAL

Silencing of D4-GDI Inhibits Growth and Invasive Behavior in MDA-MB-231 Cells by Activation of Rac-dependent p38 and JNK Signaling

(2009) Yaqin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

Rac3 inhibits adhesion and differentiation of neuronal cells by modifying GIT1 downstream signaling

(2009) A. Hajdo-Milasinovic et al.   JOURNAL OF CELL SCIENCE

Coordination of Rho GTPase activities during cell protrusion

(2009) Matthias Machacek et al.   NATURE

Assembly and biological role of podosomes and invadopodia

(2008) Mario Gimona et al.   CURRENT OPINION IN CELL BIOLOGY

Invadopodia and Matrix Degradation, a New Property of Prostate Cancer Cells during Migration and Invasion

(2008) Bhavik Desai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interaction of IQGAP1 with the exocyst complex is required for tumor cell invasion downstream of Cdc42 and RhoA

(2008) Mika Sakurai-Yageta et al.   JOURNAL OF CELL BIOLOGY