DENND2B activates Rab13 at the leading edge of migrating cells and promotes metastatic behavior

Bioinformatics analysis reveals disturbance mechanism of MAPK signaling pathway and cell cycle in Glioblastoma multiforme

(2014) Wusheng Li et al.   GENE

A Trio–Rac1–Pak1 signalling axis drives invadopodia disassembly

(2014) Yasmin Moshfegh et al.   NATURE CELL BIOLOGY

A New Genetically Encoded Single-Chain Biosensor for Cdc42 Based on FRET, Useful for Live-Cell Imaging

(2014) Samer Hanna et al.   PLoS One

Rab13 acts downstream of the kinase Mst1 to deliver the integrin LFA-1 to the cell surface for lymphocyte trafficking

(2014) A. Nishikimi et al.   Science Signaling

The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs

(2013) Timothy P. Levine et al.   BIOINFORMATICS

LncRNA expression signatures of twist-induced epithelial-to-mesenchymal transition in MCF10A cells

(2013) Ping Hu et al.   CELLULAR SIGNALLING

Junctional Rab13-binding protein (JRAB) regulates cell spreading via filamins

(2013) Ayuko Sakane et al.   GENES TO CELLS

Identification of Novel AR-Targeted MicroRNAs Mediating Androgen Signalling through Critical Pathways to Regulate Cell Viability in Prostate Cancer

(2013) Wenjuan Mo et al.   PLoS One

Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation

(2013) K. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Met synergizes with p53 loss to induce mammary tumors that possess features of claudin-low breast cancer

(2013) J. F. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

Endocytosis and Cancer

(2013) I. Mellman et al.   Cold Spring Harbor Perspectives in Biology

NECAP 1 Regulates AP-2 Interactions to Control Vesicle Size, Number, and Cargo During Clathrin-Mediated Endocytosis

(2013) Brigitte Ritter et al.   PLOS BIOLOGY

Untangling the evolution of Rab G proteins: implications of a comprehensive genomic analysis

(2012) Tobias H Klöpper et al.   BMC BIOLOGY

Rab13 Small G Protein and Junctional Rab13-binding Protein (JRAB) Orchestrate Actin Cytoskeletal Organization during Epithelial Junctional Development

(2012) Ayuko Sakane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition

(2012) Jeanine Pignatelli et al.   JOURNAL OF CELL BIOLOGY

Interplay between Rab35 and Arf6 controls cargo recycling to coordinate cell adhesion and migration

(2012) P. D. Allaire et al.   JOURNAL OF CELL SCIENCE

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer

(2012) R. K. Nookala et al.   Open Biology

Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease

(2012) Dapeng Zhang et al.   Frontiers in Genetics

Life at the Leading Edge

(2011) Anne J. Ridley   CELL

A Novel Spatiotemporal RhoC Activation Pathway Locally Regulates Cofilin Activity at Invadopodia

(2011) Jose Javier Bravo-Cordero et al.   CURRENT BIOLOGY

DENN Domain Proteins: Regulators of Rab GTPases

(2011) Andrea L. Marat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MICAL-like1 mediates epidermal growth factor receptor endocytosis

(2011) Nancy Abou-Zeid et al.   MOLECULAR BIOLOGY OF THE CELL

Connecdenn 3/DENND1C binds actin linking Rab35 activation to the actin cytoskeleton

(2011) Andrea L. Marat et al.   MOLECULAR BIOLOGY OF THE CELL

Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate

(2011) X. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Connecdenn Family, Rab35 Guanine Nucleotide Exchange Factors Interfacing with the Clathrin Machinery

(2010) Andrea L. Marat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors

(2010) Shin-ichiro Yoshimura et al.   JOURNAL OF CELL BIOLOGY

The Connecdenn DENN Domain: A GEF for Rab35 Mediating Cargo-Specific Exit from Early Endosomes

(2010) Patrick D. Allaire et al.   MOLECULAR CELL

Intersectin Regulates Dendritic Spine Development and Somatodendritic Endocytosis but Not Synaptic Vesicle Recycling in Hippocampal Neurons

(2009) Sébastien Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab13 Regulates Neurite Outgrowth in PC12 Cells through Its Effector Protein, JRAB/MICAL-L2

(2009) A. Sakane et al.   MOLECULAR AND CELLULAR BIOLOGY

Rab GTPases as coordinators of vesicle traffic

(2009) Harald Stenmark   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Filamins Regulate Cell Spreading and Initiation of Cell Migration

(2009) Massimiliano Baldassarre et al.   PLoS One

Scyl1, Mutated in a Recessive Form of Spinocerebellar Neurodegeneration, Regulates COPI-mediated Retrograde Traffic

(2008) Jonathon L. Burman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab13 regulates membrane trafficking between TGN and recycling endosomes in polarized epithelial cells

(2008) Rita L. Nokes et al.   JOURNAL OF CELL BIOLOGY

Large Scale Screening for Novel Rab Effectors Reveals Unexpected Broad Rab Binding Specificity

(2008) Mitsunori Fukuda et al.   MOLECULAR & CELLULAR PROTEOMICS

Imaging of Rab5 activity identifies essential regulators for phagosome maturation

(2008) Masahiro Kitano et al.   NATURE

Endocytic transport of integrins during cell migration and invasion

(2008) Patrick Caswell et al.   TRENDS IN CELL BIOLOGY

The Interaction of JRAB/MICAL-L2 with Rab8 and Rab13 Coordinates the Assembly of Tight Junctions and Adherens Junctions

(2007) Rie Yamamura et al.   MOLECULAR BIOLOGY OF THE CELL