Spatial and temporal signal processing and decision making by MAPK pathways

Parallel Actin-Independent Recycling Pathways Polarize Cdc42 in Budding Yeast

(2016) Benjamin Woods et al.   CURRENT BIOLOGY

Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway

(2016) Patrick Conlon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Switch-like Transitions Insulate Network Motifs to Modularize Biological Networks

(2016) Oguzhan Atay et al.   Cell Systems

Compartmentalization of a Bistable Switch Enables Memory to Cross a Feedback-Driven Transition

(2015) Andreas Doncic et al.   CELL

Role of Polarized G Protein Signaling in Tracking Pheromone Gradients

(2015) Allison W. McClure et al.   DEVELOPMENTAL CELL

A Cellular System for Spatial Signal Decoding in Chemical Gradients

(2015) Björn Hegemann et al.   DEVELOPMENTAL CELL

Modulation of receptor dynamics by the regulator of G protein signaling Sst2

(2015) Sai Phanindra Venkatapurapu et al.   MOLECULAR BIOLOGY OF THE CELL

Pheromone-induced morphogenesis and gradient tracking are dependent on the MAPK Fus3 binding to Gα

(2015) Beverly Errede et al.   MOLECULAR BIOLOGY OF THE CELL

Frequency modulation of ERK activation dynamics rewires cell fate

(2015) H. Ryu et al.   Molecular Systems Biology

Oscillatory stress stimulation uncovers an Achilles heel of the yeast MAPK signaling network

(2015) A. Mitchell et al.   SCIENCE

MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast

(2015) J. G. English et al.   Science Signaling

Spontaneous Cdc42 Polarization Independent of GDI-Mediated Extraction and Actin-Based Trafficking

(2015) Felipe O. Bendezú et al.   PLOS BIOLOGY

Role of competition between polarity sites in establishing a unique front

(2015) Chi-Fang Wu et al.   eLife

Intercellular propagation of extracellular signal-regulated kinase activation revealed by in vivo imaging of mouse skin

(2015) Toru Hiratsuka et al.   eLife

MAPK feedback encodes a switch and timer for tunable stress adaptation in yeast

(2015) J. G. English et al.   Science Signaling

Inhibitory GEF Phosphorylation Provides Negative Feedback in the Yeast Polarity Circuit

(2014) Chun-Chen Kuo et al.   CURRENT BIOLOGY

Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range

(2014) Alejandra C. Ventura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hog1: 20 years of discovery and impact

(2014) J. L. Brewster et al.   Science Signaling

Quantitative Analysis of Membrane Trafficking in Regulation of Cdc42 Polarity

(2014) Leah J. Watson et al.   TRAFFIC

Quantitative Measurement of Protein Relocalization in Live Cells

(2013) Alan Bush et al.   BIOPHYSICAL JOURNAL

A Super-Assembly of Whi3 Encodes Memory of Deceptive Encounters by Single Cells during Yeast Courtship

(2013) Fabrice Caudron et al.   CELL

Encoding and Decoding Cellular Information through Signaling Dynamics

(2013) Jeremy E. Purvis et al.   CELL

Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42

(2013) Sarah E. Smith et al.   JOURNAL OF CELL BIOLOGY

Feedforward Regulation Ensures Stability and Rapid Reversibility of a Cellular State

(2013) Andreas Doncic et al.   MOLECULAR CELL

Stochastic ERK Activation Induced by Noise and Cell-to-Cell Propagation Regulates Cell Density-Dependent Proliferation

(2013) Kazuhiro Aoki et al.   MOLECULAR CELL

An Algorithm to Automate Yeast Segmentation and Tracking

(2013) Andreas Doncic et al.   PLoS One

Pheromone-Induced Morphogenesis Improves Osmoadaptation Capacity by Activating the HOG MAPK Pathway

(2013) R. Baltanas et al.   Science Signaling

Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops

(2013) Tina Freisinger et al.   Nature Communications

Designing Synthetic Regulatory Networks Capable of Self-Organizing Cell Polarization

(2012) Angela H. Chau et al.   CELL

Gene Regulatory Logic for Reading the Sonic Hedgehog Signaling Gradient in the Vertebrate Neural Tube

(2012) Nikolaos Balaskas et al.   CELL

Negative Feedback Enhances Robustness in the Yeast Polarity Establishment Circuit

(2012) Audrey S. Howell et al.   CELL

Tracking Shallow Chemical Gradients by Actin-Driven Wandering of the Polarization Site

(2012) Jayme M. Dyer et al.   CURRENT BIOLOGY

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast

(2012) Jörg Schaber et al.   Molecular Systems Biology

Conformational Control of the Ste5 Scaffold Protein Insulates Against MAP Kinase Misactivation

(2012) J. G. Zalatan et al.   SCIENCE

Modeling Vesicle Traffic Reveals Unexpected Consequences for Cdc42p-Mediated Polarity Establishment

(2011) Anita T. Layton et al.   CURRENT BIOLOGY

Symmetry breaking and the establishment of cell polarity in budding yeast

(2011) Jayme M Johnson et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Distinct Interactions Select and Maintain a Specific Cell Fate

(2011) Andreas Doncic et al.   MOLECULAR CELL

Signal-dependent dynamics of transcription factor translocation controls gene expression

(2011) Nan Hao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range

(2011) T. M. Thomson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Scaffold Proteins: Hubs for Controlling the Flow of Cellular Information

(2011) M. C. Good et al.   SCIENCE

Yeast Dynamically Modify Their Environment to Achieve Better Mating Efficiency

(2011) M. Jin et al.   Science Signaling

The scaffold protein Ste5 directly controls a switch-like mating decision in yeast

(2010) Mohan K. Malleshaiah et al.   NATURE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling

(2010) L. S. Garrenton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Analysis Reveals That Insulation Maintains Signaling Specificity Between Two Yeast MAPK Pathways with Common Components

(2010) J. C. Patterson et al.   Science Signaling

Singularity in Polarization: Rewiring Yeast Cells to Make Two Buds

(2009) Audrey S. Howell et al.   CELL

The Ste5 Scaffold Directs Mating Signaling by Catalytically Unlocking the Fus3 MAP Kinase for Activation

(2009) Matthew Good et al.   CELL

A Systems-Level Analysis of Perfect Adaptation in Yeast Osmoregulation

(2009) Dale Muzzey et al.   CELL

Dual Modes of Cdc42 Recycling Fine-Tune Polarized Morphogenesis

(2009) Brian D. Slaughter et al.   DEVELOPMENTAL CELL

Control of high osmolarity signalling in the yeast Saccharomyces cerevisiae

(2009) Stefan Hohmann   FEBS LETTERS

Dynamics and Variability of ERK2 Response to EGF in Individual Living Cells

(2009) Cellina Cohen-Saidon et al.   MOLECULAR CELL

Quantitative effect of scaffold abundance on signal propagation

(2009) Stephen A Chapman et al.   Molecular Systems Biology

Dynamic analysis of MAPK signaling using a high-throughput microfluidic single-cell imaging platform

(2009) R. J. Taylor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cost of gene expression underlies a fitness trade-off in yeast

(2009) G. I. Lang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Signaling in the Hog1 MAPK Pathway Relies on High Basal Signal Transduction

(2009) J. Macia et al.   Science Signaling

Daughter-Specific Transcription Factors Regulate Cell Size Control in Budding Yeast

(2009) Stefano Di Talia et al.   PLOS BIOLOGY

Membrane Localization of Scaffold Proteins Promotes Graded Signaling in the Yeast MAP Kinase Cascade

(2008) Satoe Takahashi et al.   CURRENT BIOLOGY

Symmetry-Breaking Polarization Driven by a Cdc42p GEF-PAK Complex

(2008) Lukasz Kozubowski et al.   CURRENT BIOLOGY

Dynamics of Cdc42 network embodies a Turing-type mechanism of yeast cell polarity

(2008) Andrew B. Goryachev et al.   FEBS LETTERS

Nucleus-Specific and Cell Cycle-Regulated Degradation of Mitogen-Activated Protein Kinase Scaffold Protein Ste5 Contributes to the Control of Signaling Competence

(2008) L. S. Garrenton et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of Cell Signaling Dynamics by the Protein Kinase-Scaffold Ste5

(2008) Nan Hao et al.   MOLECULAR CELL

On the spontaneous emergence of cell polarity

(2008) Steven J. Altschuler et al.   NATURE

Frequency-modulated nuclear localization bursts coordinate gene regulation

(2008) Long Cai et al.   NATURE

Positive feedback of G1 cyclins ensures coherent cell cycle entry

(2008) Jan M. Skotheim et al.   NATURE

Negative feedback that improves information transmission in yeast signalling

(2008) Richard C. Yu et al.   NATURE

The ground state of embryonic stem cell self-renewal

(2008) Qi-Long Ying et al.   NATURE

Robust Spatial Sensing of Mating Pheromone Gradients by Yeast Cells

(2008) Travis I. Moore et al.   PLoS One

Signal processing by the HOG MAP kinase pathway

(2008) P. Hersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Frequency Dependence of Osmo-Adaptation in Saccharomyces cerevisiae

(2008) J. T. Mettetal et al.   SCIENCE