Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells

KiT: a MATLAB package for kinetochore tracking

(2016) Jonathan W. Armond et al.   BIOINFORMATICS

Centrosome amplification induces high grade features and is prognostic of worse outcomes in breast cancer

(2016) Ryan A. Denu et al.   BMC CANCER

The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling

(2016) Janina Hendrick et al.   JOURNAL OF CELL SCIENCE

Dynein Transmits Polarized Actomyosin Cortical Flows to Promote Centrosome Separation

(2016) Alessandro De Simone et al.   Cell Reports

Moesin Is a Major Regulator of Centrosome Behavior in Epithelial Cells with Extra Centrosomes

(2015) Dora Sabino et al.   CURRENT BIOLOGY

Direct Microtubule-Binding by Myosin-10 Orients Centrosomes toward Retraction Fibers and Subcortical Actin Clouds

(2015) Mijung Kwon et al.   DEVELOPMENTAL CELL

Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis

(2015) Özdemirhan Serçin et al.   NATURE CELL BIOLOGY

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse

(2015) Paula A. Coelho et al.   Open Biology

E-cadherin loss alters cytoskeletal organization and adhesion in non-malignant breast cells but is insufficient to induce an epithelial-mesenchymal transition

(2014) Augustine Chen et al.   BMC CANCER

Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers

(2014) A. R. Harris et al.   JOURNAL OF CELL SCIENCE

Oncogene-like induction of cellular invasion from centrosome amplification

(2014) Susana A. Godinho et al.   NATURE

Dynamic contacts: rearranging adherens junctions to drive epithelial remodelling

(2014) Masatoshi Takeichi   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Causes and consequences of centrosome abnormalities in cancer

(2014) S. A. Godinho et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery and Mechanistic Study of a Small Molecule Inhibitor for Motor Protein KIFC1

(2013) Jiaquan Wu et al.   ACS Chemical Biology

Design, Synthesis, and Biological Evaluation of an Allosteric Inhibitor of HSET that Targets Cancer Cells with Supernumerary Centrosomes

(2013) Ciorsdaidh A. Watts et al.   CHEMISTRY & BIOLOGY

A Clinical Overview of Centrosome Amplification in Human Cancers

(2012) Jason Yongsheng Chan   International Journal of Biological Sciences

Never tear us apart - the importance of centrosome clustering

(2012) V. Marthiens et al.   JOURNAL OF CELL SCIENCE

Structure of the Discoidin Domain Receptor 1 Extracellular Region Bound to an Inhibitory Fab Fragment Reveals Features Important for Signaling

(2012) Federico Carafoli et al.   STRUCTURE

Experimental validation of atomic force microscopy-based cell elasticity measurements

(2011) Andrew R Harris et al.   NANOTECHNOLOGY

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

(2011) Kristen L. Meerbrey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Significance of E-cadherin expression in triple-negative breast cancer

(2010) S Kashiwagi et al.   BRITISH JOURNAL OF CANCER

A novel microtubule-modulating noscapinoid triggers apoptosis by inducing spindle multipolarity via centrosome amplification and declustering

(2010) P Karna et al.   CELL DEATH AND DIFFERENTIATION

Centriole Reduplication during Prolonged Interphase Requires Procentriole Maturation Governed by Plk1

(2010) Jadranka Lončarek et al.   CURRENT BIOLOGY

DDR1 regulates the stabilization of cell surface E-cadherin and E-cadherin-mediated cell aggregation

(2010) Rajalakshmanan Eswaramoorthy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Collective cell migration requires suppression of actomyosin at cell–cell contacts mediated by DDR1 and the cell polarity regulators Par3 and Par6

(2010) Cristina Hidalgo-Carcedo et al.   NATURE CELL BIOLOGY

Rapid functional dissection of genetic networks via tissue-specific transduction and RNAi in mouse embryos

(2010) Slobodan Beronja et al.   NATURE MEDICINE

Membrane Invaginations Reveal Cortical Sites that Pull on Mitotic Spindles in One-Cell C. elegans Embryos

(2010) Stefanie Redemann et al.   PLoS One

Proteins Required for Centrosome Clustering in Cancer Cells

(2010) B. Leber et al.   Science Translational Medicine

Cadherin Adhesion Receptors Orient the Mitotic Spindle during Symmetric Cell Division in Mammalian Epithelia

(2009) Nicole den Elzen et al.   MOLECULAR BIOLOGY OF THE CELL

A mechanism linking extra centrosomes to chromosomal instability

(2009) Neil J. Ganem et al.   NATURE

Multipolar Spindle Pole Coalescence Is a Major Source of Kinetochore Mis-Attachment and Chromosome Mis-Segregation in Cancer Cells

(2009) William T. Silkworth et al.   PLoS One

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

(2009) Eric Campeau et al.   PLoS One

Centrosome function in cancer: guilty or innocent?

(2009) Deborah Zyss et al.   TRENDS IN CELL BIOLOGY

Loss of E-Cadherin Promotes Metastasis via Multiple Downstream Transcriptional Pathways

(2008) T. T. Onder et al.   CANCER RESEARCH

Centrosome Amplification Can Initiate Tumorigenesis in Flies

(2008) Renata Basto et al.   CELL

Moesin Controls Cortical Rigidity, Cell Rounding, and Spindle Morphogenesis during Mitosis

(2008) Patricia Kunda et al.   CURRENT BIOLOGY

Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes

(2008) M. Kwon et al.   GENES & DEVELOPMENT

Moesin and its activating kinase Slik are required for cortical stability and microtubule organization in mitotic cells

(2008) Sébastien Carreno et al.   JOURNAL OF CELL BIOLOGY

Kinesin-14 Family Proteins HSET/XCTK2 Control Spindle Length by Cross-Linking and Sliding Microtubules

(2008) Shang Cai et al.   MOLECULAR BIOLOGY OF THE CELL

Extra centrosomes and/or chromosomes prolong mitosis in human cells

(2008) Zhenye Yang et al.   NATURE CELL BIOLOGY