Epidermal Growth Factor Activates the Rho GTPase-activating Protein (GAP) Deleted in Liver Cancer 1 via Focal Adhesion Kinase and Protein Phosphatase 2A

Concerted modulation of paxillin dynamics at focal adhesions by deleted in liver cancer-1 and focal adhesion kinase during early cell spreading

(2014) Shelly Kaushik et al.   Cytoskeleton

Functional Cross-talk between Ras and Rho Pathways

(2014) Mamta Jaiswal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay of RhoA and mechanical forces in collective cell migration driven by leader cells

(2014) M. Reffay et al.   NATURE CELL BIOLOGY

PKA-induced dimerization of the RhoGAP DLC1 promotes its inhibition of tumorigenesis and metastasis

(2013) Frankie Chi Fat Ko et al.   Nature Communications

Functional Interaction of Tumor Suppressor DLC1 and Caveolin-1 in Cancer Cells

(2012) X. Du et al.   CANCER RESEARCH

Modularity and functional plasticity of scaffold proteins as p(l)acemakers in cell signaling

(2012) Catherine Qiurong Pan et al.   CELLULAR SIGNALLING

Differential regulation of the activity of deleted in liver cancer 1 (DLC1) by tensins controls cell migration and transformation

(2012) X. Cao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Akt Phosphorylation of Deleted in Liver Cancer 1 Abrogates Its Suppression of Liver Cancer Tumorigenesis and Metastasis

(2010) Frankie Chi Fat Ko et al.   GASTROENTEROLOGY

Antitumor antibiotic fostriecin covalently binds to cysteine-269 residue of protein phosphatase 2A catalytic subunit in mammalian cells

(2009) Toshifumi Takeuchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Role of DLC-1, a tumor suppressor protein with RhoGAP activity, in regulation of the cytoskeleton and cell motility

(2009) T. Y. Kim et al.   CANCER AND METASTASIS REVIEWS

Overexpression of DLC-1 induces cell apoptosis and proliferation inhibition in the renal cell carcinoma

(2009) Tao Zhang et al.   CANCER LETTERS

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

(2009) Alok Tomar et al.   CURRENT OPINION IN CELL BIOLOGY

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration

(2009) D. Zhong et al.   JOURNAL OF CELL SCIENCE

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

Deleted in Liver Cancer 1 (DLC1) Utilizes a Novel Binding Site for Tensin2 PTB Domain Interaction and Is Required for Tumor-Suppressive Function

(2009) Lo-Kong Chan et al.   PLoS One

Mutations in the Focal Adhesion Targeting Region of Deleted in Liver Cancer-1 Attenuate Their Expression and Function

(2008) Y.-C. Liao et al.   CANCER RESEARCH

DLC1: a significant GAP in the cancer genome

(2008) A. Lahoz et al.   GENES & DEVELOPMENT

Effects of Structure of Rho GTPase-activating Protein DLC-1 on Cell Morphology and Migration

(2008) Tai Young Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DLC1 interacts with 14-3-3 proteins to inhibit RhoGAP activity and block nucleocytoplasmic shuttling

(2008) R.-P. Scholz et al.   JOURNAL OF CELL SCIENCE

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms

(2007) Kevin D. Healy et al.   MOLECULAR CARCINOGENESIS