Article
Multidisciplinary Sciences
Dhirendra Sahoo, Sushreesangita P. Behera, Jyoti Shakya, Bhaskar Kaviraj
Summary: This study proposes a simple and economical method for synthesizing luminescent MoS2 nanocrystals and evaluates their potential applications in lung cancer cells.
Article
Chemistry, Multidisciplinary
Pradip Das, Silvia Pujals, Lamiaa M. A. Ali, Magali Gary-Bobo, Lorenzo Albertazzi, Jean-Olivier Durand
Summary: In this study, the degradation of biodegradable periodic mesoporous organosilica nanoparticles (nanoPMOs) triggered by glutathione and the multivalency of antibody-conjugated nanoPMOs were quantified using direct stochastic optical reconstruction microscopy (dSTORM). The impact of these properties on cancer cell targeting, drug loading and release capability, and anticancer activity were also investigated. The higher spatial resolution of dSTORM imaging enabled the characterization of structural properties of fluorescent and biodegradable nanoPMOs. The quantification of nanoPMOs' biodegradation using dSTORM imaging demonstrated their excellent structure-dependent degradation behavior at a higher glutathione concentration. The surface functionality of anti-M6PR antibody-conjugated nanoPMOs, as quantified by dSTORM imaging, played a key role in prostate cancer cell labeling and the higher biodegradability and cancer cell-targeting properties of nanorods conjugated with oriented antibody effectively delivered the anticancer drug doxorubicin to cancer cells, exhibiting potent anticancer effects.
Article
Chemistry, Multidisciplinary
Bac Thanh Le, Chau Que Nguyen, Phuong Thi Nguyen, Ha Duc Ninh, Tri Minh Le, Phuong Thi Hoai Nguyen, Duong Duc La
Summary: In this study, a porous FeBDC-PEG material was successfully constructed and tested for its drug delivery properties. The FeBDC-PEG showed a high loading capacity and efficient release of 5-fluorouracil. Additionally, the study demonstrated the safety and stability of FeBDC-PEG in mice.
Article
Chemistry, Multidisciplinary
Natalia Vtyurina, Christoffer Aberg, Anna Salvati
Summary: Live cell imaging is a powerful tool for understanding how nano-sized objects are taken up and trafficked by cells. The study found high variability in intracellular trafficking kinetics between individual cells and how nanoparticle properties affect cellular uptake and intracellular distribution kinetics.
Article
Chemistry, Multidisciplinary
Thi Khoa My Nguyen, Mi Ran Ki, Ryeo Gang Son, Kyung Hee Kim, Junghwa Hong, Seung Pil Pack
Summary: In this study, silica-forming peptides were fused to human ferritin heavy chains to generate biosilica nanoparticles with sizes below 50 nm, which were then utilized in a drug delivery system for doxorubicin to efficiently target cancer cells. This new achievement of uniform biosilica nanoparticle generation and ideal pH-dependent drug release design presents a promising strategy for efficient drug delivery to target cells.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi, Ilaria Rea
Summary: This study combined inorganic diatomite nanoparticles with gelatin-stabilized gold nanoparticles to develop an optical platform for drug delivery. By increasing the thickness of the gelatin shells, the drug loading capacity was improved. Optical modeling was used to monitor drug release processes and proved to be an efficient tool for designing polymer-coated nanocarriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Inorganic & Nuclear
Xi-yu Sun, Hong-jing Zhang, Qian Sun, En-qing Gao
Summary: In this study, iron-based crystalline porous materials were constructed as drug delivery systems with high loading capacity and controllable structures. These materials exhibited high adsorption selectivity for anticancer drug 5-fluorouracil (5-Fu) due to their suitable pore size and electrostatic force. Furthermore, they demonstrated sustained release kinetics for up to 96 hours with pH-responsive controlled release, prolonging the release process and decreasing plasma concentration. The biocompatibility of the materials was also satisfactory. This work has significant research significance and application value for the development of novel drug delivery materials.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Medicinal
Hanaa Ali Hussein, Muhammad Shahid Nazir, Nizakat Azra, Zeenat Qamar, Azman Seeni, Tengku Ahmad Damitri Al-Astani Tengku Din, Mohd Azmuddin Abdullah
Summary: Mesoporous silica nanoparticles (MSNs) have unique properties that make them widely used in drug delivery systems. However, the synthesis process of MSNs is expensive and impractical. Biosilica from marine diatoms provides a viable alternative material. This review highlights the applications of biosilica in drug delivery, biosensing, imaging agents, and regenerative medicine, and discusses the future development prospects.
Review
Biotechnology & Applied Microbiology
Ashish Ranjan Sharma, Yeon-Hee Lee, Altanzul Bat-Ulzii, Manojit Bhattacharya, Chiranjib Chakraborty, Sang-Soo Lee
Summary: Recent efforts in designing nanomaterials for targeted drug delivery, especially for nucleic acids, have revolutionized the next-generation therapy by overcoming traditional pharmaceutical challenges.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Cell Biology
Mengping Liu, Lin Wang, Young Lo, Simon Chi-Chin Shiu, Andrew B. Kinghorn, Julian A. Tanner
Summary: The interdisciplinary field of nanomaterials and aptamer science has significant potential for biomedical applications in drug delivery, imaging, and therapy. However, there are challenges to be addressed for their future development.
Review
Biochemistry & Molecular Biology
Xu Zuo, Xiaoping Guo, Yinuo Gu, Haoyu Zheng, Zhengjie Zhou, Xinlei Wang, Shengyu Jiang, Guoqiang Wang, Caina Xu, Fang Wang
Summary: Asthma is a chronic airway inflammatory disease with complex mechanisms. Clinical treatments for asthma are currently based on glucocorticoid-based combination drug therapy, but more effective treatments are needed due to glucocorticoid resistance and multiple side effects. Nanotechnology provides promising solutions for drug delivery, improving targeting and bioavailability. This review discusses the mechanisms and current therapeutic methods of asthma, as well as the design and synthesis of various nanomaterials for asthma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Chemical
Rashmi Trivedi, Tarun Kumar Upadhyay, Mohd Hasan Mujahid, Fahad Khan, Pratibha Pandey, Amit Baran Sharangi, Khursheed Muzammil, Nazim Nasir, Atiq Hassan, Nadiyah M. Alabdallah, Sadaf Anwar, Samra Siddiqui, Mohd Saeed
Summary: Nanotechnology involves multiple disciplines such as engineering, physics, chemistry, and biology. The utilization of metallic nanoparticles in bio-engineering and bio-medicine has attracted attention. Medical nanotechnology research has significant health benefits for humans. However, there are still unresolved issues in the development of nanomaterials to ensure their safety for living organisms. Nanoparticles have unique value in biology and materials science, with various applications, especially in the development of new materials.
Review
Pharmacology & Pharmacy
Mehrab Pourmadadi, Mohammad Mahdi Eshaghi, Shima Ostovar, Zahra Mohammadi, Rakesh K. Sharma, Ana Claudia Paiva-Santos, Erfan Rahmani, Abbas Rahdar, Sadanand Pandey
Summary: The rapid development of nanotechnology has led to the emergence of nanomedicine drugs, which have great potential for improving cancer treatment strategies. Nanomedicine products allow for versatile and advanced targeting tactics. Nanoparticles play a pivotal role in contemporary medical practice, with various uses such as drug transport, gene transfer to malignancies, and contrast agents for imaging. Different types of nanostructures, including organic, inorganic, lipid, glycan-based, and synthetic polymers, have been used in the creation of novel cancer therapies. This article focuses on the function of nanoparticles in cancer treatment, including drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Chemistry, Medicinal
Jing Qian, Huang Wen, Konstantin Tamarov, Wujun Xu, Vesa-Pekka Lehto
Summary: In recent years, there has been an extensive increase in the number of studies on porous silicon (PSi) nanoparticles for biomedical applications, with a focus on its carrier properties and biotraceability. PSi has shown potential in both therapy and diagnosis, leading to the development of a nanotheranostics approach. This review paper discusses the progress in using PSi for various imaging modalities and highlights the gaps in knowledge that need to be addressed before PSi can be applied in clinical imaging.
Article
Pharmacology & Pharmacy
Agata Noelia Traverso, David Jose Fragale, Diego Luis Viale, Octavio Garate, Pablo Torres, Gaston Valverde, Alejandro Berra, Ana Vanesa Torbidoni, Juan Sebastian Yakisich, Mariano Grasselli, Martin Radrizzani
Summary: In this study, a two-step procedure for preparing biohybrid nanoparticles with a hydrophobic quantum dot core and a multilayer coating of human serum albumin is reported. These nanoparticles, decorated with proteins like human serum albumin or human transferrin, retained their fluorescent properties and showed no corona effect in the presence of serum. They were selectively taken up by lung cancer and neuroblastoma cells but not by non-cancerous cells or differentiated neurons. Moreover, digitoxin-loaded transferrin-decorated nanoparticles specifically reduced the number of lung cancer cells. Finally, the in vivo uptake of these biohybrid nanoparticles by retinal cells in mice demonstrated their excellent targeting and traceability.
Article
Engineering, Biomedical
Chiara Tramontano, Joao Pedro Martins, Luca De Stefano, Marianna Kemell, Alexandra Correia, Monica Terracciano, Nicola Borbone, Ilaria Rea, Helder A. Santos
Summary: A nanoparticle-based drug delivery system has been developed for oral administration, which targets colorectal cancer cells and enhances drug efficacy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Giovanna Chianese, Ines Fasolino, Chiara Tramontano, Luca De Stefano, Claudio Imparato, Antonio Aronne, Luigi Ambrosio, Maria Grazia Raucci, Ilaria Rea
Summary: Materials that produce free radicals have attracted attention for environmental and biomedical applications. In this study, photoluminescent ZrO2-acetylacetonate nanoparticles (ZrO2-acac NPs) were designed to generate O-2(center dot-) without light activation for the treatment of osteosarcoma (OS). The surface of ZrO2-acac NPs was modified with hyaluronic acid (HA) to increase their uptake and reactive oxygen species (ROS) generation in OS cells. The results showed that the generation of O-2(center dot-) was toxic to OS cells and could enhance the efficacy of conventional drugs.
Article
Biotechnology & Applied Microbiology
Maria Mangini, Maria Antonietta Ferrara, Gianluigi Zito, Stefano Manago, Alberto Luini, Anna Chiara De Luca, Giuseppe Coppola
Summary: Circulating tumor cells (CTCs), which retain tumor properties and heterogeneity, have high potential clinical values. However, the detection and characterization of CTCs face challenges due to their rarity and difficulty in distinguishing them from white blood cells. Efficient and rapid methods are needed to capture the broad spectrum of tumor cells circulating in the blood.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biology
Federica Scotto di Carlo, Sharon Russo, Francesc Muyas, Maria Mangini, Lorenza Garribba, Laura Pazzaglia, Rita Genesio, Flavia Biamonte, Anna Chiara De Luca, Stefano Santaguida, Katia Scotlandi, Isidro Cortes-Ciriano, Fernando Gianfrancesco
Summary: Profilin 1, encoded by PFN1, is a protein that plays a tumor suppressive role in various adenocarcinomas and pagetic osteosarcomas. However, its exact contribution to tumor development is not fully understood. This study shows that inactivation of Profilin 1 leads to multiple mitotic defects, resulting in chromosomal instability and genome rearrangements in pagetic osteosarcomas. Mechanistically, Profilin 1 is involved in regulating cell division and its deficiency impairs actin filament supply during cytokinesis.
COMMUNICATIONS BIOLOGY
(2023)
Article
Optics
Giovanni Volpe, Onofrio M. Marago, Halina Rubinsztein-Dunlop, Giuseppe Pesce, Alexander B. Stilgoe, Giorgio Volpe, Georgiy Tkachenko, Viet Giang Truong, Sile Nic Chormaic, Fatemeh Kalantarifard, Parviz Elahi, Mikael Kall, Agnese Callegari, Manuel Marques, Antonio A. R. Neves, Wendel L. Moreira, Adriana Fontes, Carlos L. Cesar, Rosalba Saija, Abir Saidi, Paul Beck, Joerg S. Eismann, Peter Banzer, Thales F. D. Fernandes, Francesco Pedaci, Warwick P. Bowen, Rahul Vaippully, Muruga Lokesh, Basudev Roy, Gregor Thalhammer-Thurner, Monika Ritsch-Marte, Laura Perez Garcia, Alejandro Arzola, Isaac Perez Castillo, Aykut Argun, Till M. Muenker, Bart E. Vos, Timo Betz, Ilaria Cristiani, Paolo Minzioni, Peter J. Reece, Fan Wang, David McGloin, Justus C. Ndukaife, Romain Quidant, Reece P. Roberts, Cyril Laplane, Thomas Volz, Reuven Gordon, Dag Hanstorp, Javier Tello Marmolejo, Graham D. Bruce, Kishan Dholakia, Tongcang Li, Oto Brzobohaty, Stephen H. Simpson, Pavel Zemanek, Felix Ritort, Yael Roichman, Valeriia Bobkova, Raphael Wittkowski, Cornelia Denz, G. V. Pavan Kumar, Antonino Foti, Maria Grazia Donato, Pietro G. Gucciardi, Lucia Gardini, Giulio Bianchi, Anatolii Kashchuk, Marco Capitanio, Lynn Paterson, Philip H. Jones, Kirstine Berg-Sorensen, Younes F. Barooji, Lene B. Oddershede, Pegah Pouladian, Daryl Preece, Caroline Beck Adiels, Anna Chiara De Luca, Alessandro Magazzu, David Bronte Ciriza, Maria Antonia Iati, Grover A. Swartzlander
Summary: Optical tweezers are tools that use light to push, trap, and manipulate objects without physical contact. Since the 1970s, they have evolved into sophisticated instruments and have been widely used in various fields such as life sciences, physics, and engineering. Applications include precise force and torque measurement, micro-rheology of complex fluids, spectroscopy of single micro- and nano-particles, single-cell analysis, and statistical-physics experiments. This roadmap provides insights into the theoretical foundations, designs, and setups of optical forces and tweezers, and offers perspectives for applications in research fields ranging from biophysics to space exploration.
JOURNAL OF PHYSICS-PHOTONICS
(2023)
Article
Biochemistry & Molecular Biology
Monica Terracciano, Simas Rackauskas, Andrea Patrizia Falanga, Sara Martino, Giovanna Chianese, Francesca Greco, Gennaro Piccialli, Guido Viscardi, Luca De Stefano, Giorgia Oliviero, Nicola Borbone, Ilaria Rea
Summary: The physicochemical properties of three different ZnO tetrapodal nanostructures (ZnO-Ts) synthesized by a combustion process were studied and evaluated for label-free biosensing purposes. The chemical reactivity of ZnO-Ts was explored by quantifying the available functional hydroxyl groups (-OH) on the transducer surface necessary for biosensor development. The best ZnO-T sample was chemically modified and bioconjugated with biotin as a model bioprobe, confirming their suitability for biosensing applications through streptavidin target detection experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sara Martino, Chiara Tammaro, Gabriella Misso, Michela Falco, Marianna Scrima, Marco Bocchetti, Ilaria Rea, Luca De Stefano, Michele Caraglia
Summary: MicroRNA (miRNA) are small nucleotides that regulate physiological functions and diseases, especially in cancer. Detection methods such as RT-qPCR, microarrays, and small RNA sequencing have been used for the past 30 years. The advent of nanotechnology has allowed the development of nanostructured biosensors, which offer advantages such as portability, large surface-volume ratio, and increased sensitivity. This review explores the role of nanostructured biosensors in miRNA detection, particularly using electrochemical and optical sensing methods, and highlights the properties and applications of different nanomaterials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Chiara Tramontano, Luca De Stefano, Ilaria Rea
Summary: Colorectal cancer is a common and deadly cancer worldwide. While screening programs and surgical techniques have reduced mortality in non-metastatic patients, survival rates for metastatic CRC remain low. Conventional chemotherapies cause harmful side effects, but nanomedicine, specifically diatomite nanoparticles, offer a potential solution. These nanoparticles can deliver chemotherapeutic agents to specific targets, reducing off-target effects. This review explores the use of diatomite-based drug delivery systems for the treatment of colorectal cancer, focusing on anti-angiogenetic drugs, antimetastatic drugs, and immune checkpoint inhibitors.
Article
Chemistry, Medicinal
Domenica Capasso, Paola Marino, Sonia Di Gaetano, Nicola Borbone, Monica Terracciano, Roberta Trani, Caterina Longo, Vincenzo Piccialli
Summary: Several five-membered bromolactones were synthesized from D-xylonolactone and D-ribonolactone, which are related to the C1-C5 portion of mycalin A lactone. The bromination of D-ribonolactone with HBr/AcOH, without transesterification, resulted in the majority of the acetylated lactones investigated. The evaluation of their anti-tumor activity indicated that the acetates possess cytotoxicity towards multiple cancer cells, with selectivity towards tumor cells and limited toxicity on healthy cells.
Article
Biophysics
S. Spaziani, G. Quero, S. Manago, G. Zito, D. Terracciano, P. E. Macchia, F. Galeotti, M. Pisco, A. C. De Luca, A. Cusano
Summary: We developed an immunoassay platform for the detection of human Thyroglobulin (Tg) in thyroid cancer patients with lymph node metastases. The platform utilizes a self-assembled surface-enhanced Raman scattering (SERS) substrate and functionalized gold nanoparticles to enhance molecular specificity and signal amplification. The platform has a low detection limit of 7 pg/mL and has been successfully applied to washout fluids from fine needle aspiration biopsies in cancer patients, demonstrating its high specificity in complex biological matrices.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biochemistry & Molecular Biology
Amina Antonacci, Valeria Frisulli, Lucas Braganca Carvalho, Leonardo Fernandes Fraceto, Bruno Miranda, Luca De Stefano, Udo Johanningmeier, Maria Teresa Giardi, Viviana Scognamiglio
Summary: A completely green biosensor was designed using eco-friendly materials to detect herbicides encapsulated in biodegradable nanoparticles for sustainable agriculture. The nanocarriers delivered herbicides to the correct location, reducing their impact on plants and the agricultural and food industries. Comprehensive information about nanoformulated herbicides in agricultural fields is crucial to support farmers in decision-making.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
