Efficient solid-phase synthesis of meningococcal capsular oligosaccharides enables simple and fast chemoenzymatic vaccine production

A semisynthetic Streptococcus pneumoniae serotype 8 glycoconjugate vaccine

(2017) Benjamin Schumann et al.   Science Translational Medicine

Synthesis and immunochemical evaluation of a novel Neisseria meningitidis serogroup A tetrasaccharide and its conjugate

(2017) Kishore R. Harale et al.   Organic Chemistry Frontiers

An efficient cell free enzyme-based total synthesis of a meningococcal vaccine candidate

(2016) Timm Fiebig et al.   npj Vaccines

Challenges and Opportunities While Developing a Group A Meningococcal Conjugate Vaccine Within a Product Development Partnership: A Manufacturer's Perspective From the Serum Institute of India

(2015) Prasad S. Kulkarni et al.   CLINICAL INFECTIOUS DISEASES

The Capsule Polymerase CslB ofNeisseria meningitidisSerogroup L Catalyzes the Synthesis of a Complex Trimeric Repeating Unit Comprising Glycosidic and Phosphodiester Linkages

(2015) Christa Litschko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vaccine shortage threatens spread of meningitis in Niger

(2015) John Maurice   LANCET

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

A Synthetic Disaccharide Analogue from Neisseria meningitidis A Capsular Polysaccharide Stimulates Immune Cell Responses and Induces Immunoglobulin G (IgG) Production in Mice When Protein-Conjugated

(2015) Silvia Fallarini et al.   ACS Infectious Diseases

Synthesis and immunological evaluation of protein conjugates ofNeisseria meningitidisX capsular polysaccharide fragments

(2014) Laura Morelli et al.   Beilstein Journal of Organic Chemistry

Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases fromNeisseria meningitidisW and Y Defines a New Sialyltransferase Family

(2014) Angela Romanow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Cloning and Functional Characterization of Components of the Capsule Biosynthesis Complex ofNeisseria meningitidisSerogroup A

(2014) Timm Fiebig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engineering the product profile of a polysialyltransferase

(2014) Timothy G Keys et al.   Nature Chemical Biology

Valuing vaccination

(2014) T. Barnighausen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunoactivity of Protein Conjugates of Carba Analogues from Neisseria meningitidis A Capsular Polysaccharide

(2013) Qi Gao et al.   ACS Chemical Biology

Recent Mechanistic Insights on Glycoconjugate Vaccines and Future Perspectives

(2013) Francesco Berti et al.   ACS Chemical Biology

Functional expression of the capsule polymerase of Neisseria meningitidis serogroup X: A new perspective for vaccine development

(2013) T. Fiebig et al.   GLYCOBIOLOGY

Biochemical and Biophysical Characterization of the Sialyl-/Hexosyltransferase Synthesizing the Meningococcal Serogroup W135 Heteropolysaccharide Capsule

(2013) Angela Romanow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X

(2013) F. Micoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emergence of serogroup X meningococcal disease in Africa: Need for a vaccine

(2013) Ouli Xie et al.   VACCINE

Glycoconjugate vaccines

(2012) David Pace   EXPERT OPINION ON BIOLOGICAL THERAPY

Relative stability of meningococcal serogroup A and X polysaccharides

(2012) F. Berti et al.   VACCINE

The design of semi-synthetic and synthetic glycoconjugate vaccines

(2011) Paolo Costantino et al.   Expert Opinion on Drug Discovery

The future of immunisation policy, implementation, and financing

(2011) Orin S Levine et al.   LANCET

A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design

(2011) Fikri Y Avci et al.   NATURE MEDICINE

Carbohydrate vaccines: developing sweet solutions to sticky situations?

(2010) Rena D. Astronomo et al.   NATURE REVIEWS DRUG DISCOVERY

A tethering mechanism for length control in a processive carbohydrate polymerization

(2009) J. F. May et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chemistry of a new investigational quadrivalent meningococcal conjugate vaccine that is immunogenic at all ages

(2009) Michael Bröker et al.   VACCINE