Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

(2017) Gang Zhang et al.   Nature Communications

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)

(2016) D. Caron et al.   Science Signaling

Cep57 is a Mis12-interacting kinetochore protein involved in kinetochore targeting of Mad1–Mad2

(2016) Haining Zhou et al.   Nature Communications

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators

(2016) Nicole St-Denis et al.   Cell Reports

Mitotic phosphotyrosine network analysis reveals that tyrosine phosphorylation regulates Polo-like kinase 1 (PLK1)

(2016) D. Caron et al.   Science Signaling

OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases

(2016) Wenbin Ji et al.   PLoS One

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore

(2015) Takashi Akera et al.   NATURE CELL BIOLOGY

Structure of an intermediate conformer of the spindle checkpoint protein Mad2

(2015) Mayuko Hara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM-mediated Mad1 Serine 214 phosphorylation regulates Mad1 dimerization and the spindle assembly checkpoint

(2014) Chunying Yang et al.   CARCINOGENESIS

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

(2014) Veronica Rodriguez-Bravo et al.   CELL

Conditional targeting of MAD1 to kinetochores is sufficient to reactivate the spindle assembly checkpoint in metaphase

(2014) Timo E. F. Kuijt et al.   CHROMOSOMA

A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

(2014) T. Kruse et al.   EMBO REPORTS

Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores

(2014) S. Heinrich et al.   EMBO REPORTS

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint

(2014) N. London et al.   GENES & DEVELOPMENT

The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis

(2014) Laura A. Diaz-Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recruitment of Mad1 to metaphase kinetochores is sufficient to reactivate the mitotic checkpoint

(2014) Edward R. Ballister et al.   JOURNAL OF CELL BIOLOGY

Signalling dynamics in the spindle checkpoint response

(2014) Nitobe London et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The internal Cdc20 binding site in BubR1 facilitates both spindle assembly checkpoint signalling and silencing

(2014) Tiziana Lischetti et al.   Nature Communications

Monopolar Spindle 1 (MPS1) Kinase Promotes Production of Closed MAD2 (C-MAD2) Conformer and Assembly of the Mitotic Checkpoint Complex

(2013) Aaron R. Tipton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Spindle Assembly Checkpoint

(2012) Pablo Lara-Gonzalez et al.   CURRENT BIOLOGY

Structure of the mitotic checkpoint complex

(2012) William C. H. Chao et al.   NATURE

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Closed MAD2 (C-MAD2) is selectively incorporated into the mitotic checkpoint complex (MCC)

(2011) Aaron R. Tipton et al.   CELL CYCLE

Probing thein vivofunction of Mad1:C-Mad2 in the spindle assembly checkpoint

(2011) Luca L Fava et al.   EMBO JOURNAL

BUBR1 and Closed MAD2 (C-MAD2) Interact Directly to Assemble a Functional Mitotic Checkpoint Complex

(2011) Aaron R. Tipton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Expression of Oncogenic Kinase Bcr-Abl Impairs Mitotic Checkpoint and Promotes Aberrant Divisions and Resistance to Microtubule-Targeting Agents

(2010) K. Wolanin et al.   MOLECULAR CANCER THERAPEUTICS

Phosphorylation of the spindle checkpoint protein Mad2 regulates its conformational transition

(2010) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

Spatiotemporal control of mitosis by the conserved spindle matrix protein Megator

(2009) Mariana Lince-Faria et al.   JOURNAL OF CELL BIOLOGY

Tpr directly binds to Mad1 and Mad2 and is important for the Mad1-Mad2-mediated mitotic spindle checkpoint

(2008) S. H. Lee et al.   GENES & DEVELOPMENT

Requirements for Protein Phosphorylation and the Kinase Activity of Polo-like Kinase 1 (Plk1) for the Kinetochore Function of Mitotic Arrest Deficiency Protein 1 (Mad1)

(2008) Ya-Hui Chi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Protein Metamorphosis: The Two-State Behavior of Mad2

(2008) Xuelian Luo et al.   STRUCTURE

Insights into Mad2 Regulation in the Spindle Checkpoint Revealed by the Crystal Structure of the Symmetric Mad2 Dimer

(2008) Maojun Yang et al.   PLOS BIOLOGY

The Role of the FH1 Domain and Profilin in Formin-Mediated Actin-Filament Elongation and Nucleation

(2007) Aditya Paul et al.   CURRENT BIOLOGY