From Eggs to Hearts: What Is the Link between Cyclic ADP-Ribose and Ryanodine Receptors?

FKBP12 and FKBP12.6 Exert Opposing Actions on the Single-Channel Behaviour of Both RyR1 and RyR2

(2010) Elisa Venturi et al.   BIOPHYSICAL JOURNAL

FKBP12 is a High Affinity, Reversible Activator of RyR2, and FKBP12.6 Antagonises Its Actions

(2010) Rebecca Sitsapesan et al.   BIOPHYSICAL JOURNAL

Luminal Ca2+ is a Major Sensitiser of Two-Pore Channels to NAADP

(2010) Samantha Jane Pitt et al.   BIOPHYSICAL JOURNAL

Purified TPC Isoforms Form NAADP Receptors with Distinct Roles for Ca2+ Signaling and Endolysosomal Trafficking

(2010) Margarida Ruas et al.   CURRENT BIOLOGY

Diadenosine pentaphosphate is a potent activator of cardiac ryanodine receptors revealing a novel high-affinity binding site for adenine nucleotides

(2009) L Song et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not β-adrenergic stimulation in mouse cardiomyocytes

(2009) Xu Zhang et al.   CARDIOVASCULAR RESEARCH

Mineralocorticoid Modulation of Cardiac Ryanodine Receptor Activity Is Associated With Downregulation of FK506-Binding Proteins

(2009) Ana María Gómez et al.   CIRCULATION

Luminal Ca2+ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains

(2009) Derek R. Laver   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

NAADP mobilizes calcium from acidic organelles through two-pore channels

(2009) Peter J. Calcraft et al.   NATURE

Lysosomes co-localize with ryanodine receptor subtype 3 to form a trigger zone for calcium signalling by NAADP in rat pulmonary arterial smooth muscle

(2008) Nicholas P. Kinnear et al.   CELL CALCIUM

Single-Channel Characterization of the Rabbit Recombinant RyR2 Reveals a Novel Inactivation Property of Physiological Concentrations of ATP

(2008) Richard Stewart et al.   JOURNAL OF MEMBRANE BIOLOGY

What role does modulation of the ryanodine receptor play in cardiac inotropy and arrhythmogenesis?

(2008) D.A. Eisner et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY