The Trypanosoma brucei Tb Hrg protein is a heme transporter involved in the regulation of stage-specific morphological transitions

Trypanosomatid parasites rescue heme from endocytosed hemoglobin through lysosomal HRG transporters

(2016) María Cabello-Donayre et al.   MOLECULAR MICROBIOLOGY

The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake

(2016) Marcelo L. Merli et al.   PLoS Neglected Tropical Diseases

Modulation of flagellum attachment zone protein FLAM3 and regulation of the cell shape in Trypanosoma brucei life cycle transitions

(2015) J. D. Sunter et al.   JOURNAL OF CELL SCIENCE

A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids

(2015) S. Dean et al.   Open Biology

The Heme Transport Capacity of LHR1 Determines the Extent of Virulence in Leishmania amazonensis

(2015) Rebecca L. Renberg et al.   PLoS Neglected Tropical Diseases

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi

(2015) Leonardo da Silva Augusto et al.   PLoS Pathogens

Extensive stage-regulation of translation revealed by ribosome profiling of Trypanosoma brucei

(2014) Bryan C Jensen et al.   BMC GENOMICS

Transcriptome-wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co-transcriptional degradation in determining mRNA levels

(2014) Abeer Fadda et al.   MOLECULAR MICROBIOLOGY

Insights into the Trypanosome-Host Interactions Revealed through Transcriptomic Analysis of Parasitized Tsetse Fly Salivary Glands

(2014) Erich Loza Telleria et al.   PLoS Neglected Tropical Diseases

HRG1 Is Essential for Heme Transport from the Phagolysosome of Macrophages during Erythrophagocytosis

(2013) Carine White et al.   Cell Metabolism

Global Quantitative SILAC Phosphoproteomics Reveals Differential Phosphorylation Is Widespread between the Procyclic and Bloodstream Form Lifecycle Stages of Trypanosoma brucei

(2013) Michael D. Urbaniak et al.   JOURNAL OF PROTEOME RESEARCH

Insights into the regulation of GPEET procyclin during differentiation from early to late procyclic forms of Trypanosoma brucei

(2013) Sebastian Knüsel et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Both human ferredoxins equally efficiently rescue ferredoxin deficiency inTrypanosoma brucei

(2013) Piya Changmai et al.   MOLECULAR MICROBIOLOGY

Flying tryps: survival and maturation of trypanosomes in tsetse flies

(2013) Naomi A. Dyer et al.   TRENDS IN PARASITOLOGY

Make It, Take It, or Leave It: Heme Metabolism of Parasites

(2013) Luděk Kořený et al.   PLoS Pathogens

More than meets the eye: understanding Trypanosoma brucei morphology in the tsetse

(2013) Cher-Pheng Ooi et al.   Frontiers in Cellular and Infection Microbiology

Heme Utilization in theCaenorhabditis elegansHypodermal Cells Is Facilitated by Heme-responsive Gene-2

(2012) Caiyong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aerobic kinetoplastid flagellate Phytomonas does not require heme for viability

(2012) L. Koreny et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heme Uptake by Leishmania amazonensis Is Mediated by the Transmembrane Protein LHR1

(2012) Chau Huynh et al.   PLoS Pathogens

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome

(2011) S. Alsford et al.   GENOME RESEARCH

Topologically Conserved Residues Direct Heme Transport in HRG-1-related Proteins

(2011) Xiaojing Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania

(2011) Jenny Campos-Salinas et al.   MOLECULAR MICROBIOLOGY

Molecular bases of cytoskeleton plasticity during the Trypanosoma brucei parasite cycle

(2010) Brice Rotureau et al.   CELLULAR MICROBIOLOGY

Composition and sensory function of the trypanosome flagellar membrane

(2010) Danijela Maric et al.   CURRENT OPINION IN MICROBIOLOGY

Cellular and Molecular Remodeling of the Endocytic Pathway during Differentiation of Trypanosoma brucei Bloodstream Forms

(2010) Benoit Vanhollebeke et al.   EUKARYOTIC CELL

Selection of reference genes for mRNA quantification in Trypanosoma brucei

(2010) Martin Brenndörfer et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genome-wide analysis of mRNA abundance in two life-cycle stages of Trypanosoma brucei and identification of splicing and polyadenylation sites

(2010) Tim Nicolai Siegel et al.   NUCLEIC ACIDS RESEARCH

Heme and blood-feeding parasites: friends or foes?

(2010) Shu Toh et al.   Parasites & Vectors

Genome-Wide Analysis Reveals Novel Genes Essential for Heme Homeostasis in Caenorhabditis elegans

(2010) Scott Severance et al.   PLoS Genetics

Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

(2009) Luděk Kořený et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Major Surface Glycoproteins of Insect Forms of Trypanosoma brucei Are Not Essential for Cyclical Transmission by Tsetse

(2009) Erik Vassella et al.   PLoS One

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE

TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex

(2008) H. Hashimi et al.   RNA

A Haptoglobin-Hemoglobin Receptor Conveys Innate Immunity to Trypanosoma brucei in Humans

(2008) B. Vanhollebeke et al.   SCIENCE