Structural insights unravel the zymogenic mechanism of the virulence factor gingipain K fromPorphyromonas gingivalis, a causative agent of gum disease from the human oral microbiome

Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans

(2016) Ron Sender et al.   CELL

A two-component system regulates gene expression of the type IX secretion component proteins via an ECF sigma factor

(2016) Tomoko Kadowaki et al.   Scientific Reports

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain

(2016) Iñaki de Diego et al.   Scientific Reports

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line

(2016) Kah Yan How et al.   Frontiers in Microbiology

Identification of protein secretion systems in bacterial genomes

(2016) Sophie S. Abby et al.   Scientific Reports

Structural and functional probing of PorZ, an essential bacterial surface component of the type-IX secretion system of human oral-microbiomic Porphyromonas gingivalis.

(2016) Anna M. Lasica et al.   Scientific Reports

Cultivating Healthy Growth and Nutrition through the Gut Microbiota

(2015) Sathish Subramanian et al.   CELL

JPred4: a protein secondary structure prediction server

(2015) Alexey Drozdetskiy et al.   NUCLEIC ACIDS RESEARCH

A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy

(2014) Shinsuke Kataoka et al.   FASEB JOURNAL

Flavobacterium johnsoniae PorV Is Required for Secretion of a Subset of Proteins Targeted to the Type IX Secretion System

(2014) Sampada S. Kharade et al.   JOURNAL OF BACTERIOLOGY

Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor ofPorphyromonas gingivalisin Periodontitis

(2014) Iñaki de Diego et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porphyromonas gingivalisand related bacteria: from colonial pigmentation to the type IX secretion system and gliding motility

(2014) K. Nakayama   JOURNAL OF PERIODONTAL RESEARCH

Pathogens and host immunity in the ancient human oral cavity

(2014) Christina Warinner et al.   NATURE GENETICS

Metagenomic Analysis Reveals Presence of Treponema denticola in a Tissue Biopsy of the Iceman

(2014) Frank Maixner et al.   PLoS One

The Human Microbiome: From Symbiosis to Pathogenesis

(2013) Emiley A. Eloe-Fadrosh et al.   Annual Review of Medicine

Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases

(2013) Florian Veillard et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections

(2013) Grzegorz Dubin et al.   CURRENT PHARMACEUTICAL DESIGN

Porphyromonas gingivalisVirulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases

(2013) Iñaki de Diego et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteinaceous determinants of surface colonization in bacteria: bacterial adhesion and biofilm formation from a protein secretion perspective

(2013) Caroline Chagnot et al.   Frontiers in Microbiology

DNA FROM HUMAN ANCIENT BACTERIA: A NOVEL SOURCE OF GENETIC EVIDENCE FROM ARCHAEOLOGICAL DENTAL CALCULUS

(2012) C. DE LA FUENTE et al.   ARCHAEOMETRY

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

(2012) Nagihan Bostanci et al.   FEMS MICROBIOLOGY LETTERS

Gliding Motility and Por Secretion System Genes Are Widespread among Members of the Phylum Bacteroidetes

(2012) Mark J. McBride et al.   JOURNAL OF BACTERIOLOGY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

REFMAC5 for the refinement of macromolecular crystal structures

(2011) Garib N. Murshudov et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

(2011) Dan R. Littman et al.   Cell Host & Microbe

Comparison of Gingival Crevicular Fluid Sampling Methods in Patients With Severe Chronic Periodontitis

(2011) Arndt Guentsch et al.   JOURNAL OF PERIODONTOLOGY

Experimental phasing withSHELXC/D/E: combining chain tracing with density modification

(2010) George M. Sheldrick   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Molecular mechanisms for the conversion of zymogens to active proteolytic enzymes

(2010) Amir R. Khan et al.   PROTEIN SCIENCE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A protein secretion system linked to bacteroidete gliding motility and pathogenesis

(2009) K. Sato et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and Mechanism of Metallocarboxypeptidases

(2008) F. Gomis-Rüth   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY