Structure and Mechanism of Cysteine Peptidase Gingipain K (Kgp), a Major Virulence Factor ofPorphyromonas gingivalisin Periodontitis

A novel, potent dual inhibitor of Arg-gingipains and Lys-gingipain as a promising agent for periodontal disease therapy

(2014) Shinsuke Kataoka et al.   FASEB JOURNAL

Binding of the Antitubercular Pro-Drug Isoniazid in the Heme Access Channel of Catalase-Peroxidase (KatG). A Combined Structural and Metadynamics Investigation

(2014) Pietro Vidossich et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Drug development: Time for teamwork

(2014) Mike May   NATURE

Antibiotic resistance: An infectious arms race

(2014) Karyn Hede   NATURE

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Metagenomic Analysis Reveals Presence of Treponema denticola in a Tissue Biopsy of the Iceman

(2014) Frank Maixner et al.   PLoS One

Periodontal Pathogens and Atherosclerosis: Implications of Inflammation and Oxidative Modification of LDL

(2014) Tomoko Kurita-Ochiai et al.   Biomed Research International

Ultratight crystal packing of a 10 kDa protein

(2013) Sergio Trillo-Muyo et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bacterial Proteases in Disease – Role in Intracellular Survival, Evasion of Coagulation/ Fibrinolysis Innate Defenses, Toxicoses and Viral Infections

(2013) Grzegorz Dubin et al.   CURRENT PHARMACEUTICAL DESIGN

Porphyromonas gingivalisVirulence Factor Gingipain RgpB Shows a Unique Zymogenic Mechanism for Cysteine Peptidases

(2013) Iñaki de Diego et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Richness of human gut microbiome correlates with metabolic markers

(2013) Emmanuelle Le Chatelier et al.   NATURE

MP:PD—a data base of internal packing densities, internal packing defects and internal waters of helical membrane proteins

(2013) Alexander Rose et al.   NUCLEIC ACIDS RESEARCH

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2013) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation

(2013) E. Dall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD)

(2013) Katarzyna J. Maresz et al.   PLoS Pathogens

The Crystal Structure of Human α2-Macroglobulin Reveals a Unique Molecular Cage

(2012) Aniebrys Marrero et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Disruption of gingipain oligomerization into non-covalent cell-surface attached complexes

(2012) Maryta Sztukowska et al.   BIOLOGICAL CHEMISTRY

Porphyromonas gingivalis: an invasive and evasive opportunistic oral pathogen

(2012) Nagihan Bostanci et al.   FEMS MICROBIOLOGY LETTERS

A systematic review on the effects of local antimicrobials as adjuncts to subgingival debridement, compared with subgingival debridement alone, in the treatment of chronic periodontitis

(2012) Paula Matesanz-Pérez et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Linking Crystallographic Model and Data Quality

(2012) P. A. Karplus et al.   SCIENCE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The modular structure of haemagglutinin/adhesin regions in gingipains of Porphyromonas gingivalis

(2011) Nan Li et al.   MOLECULAR MICROBIOLOGY

T-Coffee: a web server for the multiple sequence alignment of protein and RNA sequences using structural information and homology extension

(2011) P. Di Tommaso et al.   NUCLEIC ACIDS RESEARCH

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure determination and analysis of a haemolytic gingipain adhesin domain from Porphyromonas gingivalis

(2010) Nan Li et al.   MOLECULAR MICROBIOLOGY

Dali server: conservation mapping in 3D

(2010) Liisa Holm et al.   NUCLEIC ACIDS RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Determination of active site of lysine-specific cysteine proteinase (Lys-gingipain) by use of a Porphyromonas gingivalis plasmid system

(2008) Yutaka Ishida et al.   ARCHIVES OF ORAL BIOLOGY

Automated macromolecular model building for X-ray crystallography using ARP/wARP version 7

(2008) Gerrit Langer et al.   Nature Protocols

Hydrogen-Bonding and Packing Features of Membrane Proteins: Functional Implications

(2007) Peter Werner Hildebrand et al.   BIOPHYSICAL JOURNAL

Serine protease inhibitorsN-α-Tosyl-L-Lysinyl-Chloromethylketone (TLCK) andN-Tosyl-L-Phenylalaninyl-Chloromethylketone (TPCK) are potent inhibitors of activated caspase proteases

(2007) Ivo Frydrych et al.   JOURNAL OF CELLULAR BIOCHEMISTRY