A hypertension-associated mitochondrial DNA mutation introduces an m1G37 modification into tRNAMet, altering its structure and function

A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNALeu(UUR)

(2017) Mi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biochemical Evidence for a Nuclear Modifier Allele (A10S) in TRMU (Methylaminomethyl-2-thiouridylate-methyltransferase) Related to Mitochondrial tRNA Modification in the Phenotypic Manifestation of Deafness-associated 12S rRNA Mutation

(2017) Feilong Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis

(2017) Juanjuan Zhang et al.   Scientific Reports

The defective expression of gtpbp3 related to tRNA modification alters the mitochondrial function and development of zebrafish

(2016) Danni Chen et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sequence-specific and Shape-selective RNA Recognition by the Human RNA 5-Methylcytosine Methyltransferase NSun6

(2016) Tao Long et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Deafness- and Diabetes-associated tRNA Mutation Causes Deficient Pseudouridinylation at Position 55 in tRNAGluand Mitochondrial Dysfunction

(2016) Meng Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial tRNA mutations in 2070 Chinese Han subjects with hypertension

(2016) Ling Xue et al.   MITOCHONDRION

A Hypertension-Associated tRNAAlaMutation Alters tRNA Metabolism and Mitochondrial Function

(2016) Pingping Jiang et al.   MOLECULAR AND CELLULAR BIOLOGY

NSUN3 methylase initiates 5-formylcytidine biogenesis in human mitochondrial tRNAMet

(2016) Saori Nakano et al.   Nature Chemical Biology

A deafness-associated tRNAAspmutation alters the m1G37 modification, aminoacylation and stability of tRNAAspand mitochondrial function

(2016) Meng Wang et al.   NUCLEIC ACIDS RESEARCH

Small RNA Modifications: Integral to Function and Disease

(2016) Xudong Zhang et al.   TRENDS IN MOLECULAR MEDICINE

Deficient methylation and formylation of mt-tRNAMet wobble cytosine in a patient carrying mutations in NSUN3

(2016) Lindsey Van Haute et al.   Nature Communications

TRMT5 Mutations Cause a Defect in Post-transcriptional Modification of Mitochondrial tRNA Associated with Multiple Respiratory-Chain Deficiencies

(2015) Christopher A. Powell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Oxidative stress in inherited mitochondrial diseases

(2015) Genki Hayashi et al.   FREE RADICAL BIOLOGY AND MEDICINE

The exome sequencing identified the mutation in YARS2 encoding the mitochondrial tyrosyl-tRNA synthetase as a nuclear modifier for the phenotypic manifestation of Leber's hereditary optic neuropathy-associated mitochondrial DNA mutation

(2015) Pingping Jiang et al.   HUMAN MOLECULAR GENETICS

Identification of determinants for tRNA substrate recognition byEscherichia coliC/U34 2′-O-methyltransferase

(2015) Mi Zhou et al.   RNA Biology

Nuclear-encoded factors involved in post-transcriptional processing and modification of mitochondrial tRNAs in human disease

(2015) Christopher A. Powell et al.   Frontiers in Genetics

MTO1 mediates tissue specificity of OXPHOS defects via tRNA modification and translation optimization, which can be bypassed by dietary intervention

(2015) Christin Tischner et al.   HUMAN MOLECULAR GENETICS

Mutations in GTPBP3 Cause a Mitochondrial Translation Defect Associated with Hypertrophic Cardiomyopathy, Lactic Acidosis, and Encephalopathy

(2014) Robert Kopajtich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

ROS Function in Redox Signaling and Oxidative Stress

(2014) Michael Schieber et al.   CURRENT BIOLOGY

Mitochondrial disease associated with complex I (NADH-CoQ oxidoreductase) deficiency

(2014) Immo E. Scheffler   JOURNAL OF INHERITED METABOLIC DISEASE

A deafness-associated tRNAHismutation alters the mitochondrial function, ROS production and membrane potential

(2014) Shasha Gong et al.   NUCLEIC ACIDS RESEARCH

A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs

(2014) T. Suzuki et al.   NUCLEIC ACIDS RESEARCH

Defective i6A37 Modification of Mitochondrial and Cytosolic tRNAs Results from Pathogenic Mutations in TRIT1 and Its Substrate tRNA

(2014) John W. Yarham et al.   PLoS Genetics

Methylated nucleosides in tRNA and tRNA methyltransferases

(2014) Hiroyuki Hori   Frontiers in Genetics

Mutations of the Mitochondrial-tRNA Modifier MTO1 Cause Hypertrophic Cardiomyopathy and Lactic Acidosis

(2012) Daniele Ghezzi et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Biosynthesis and Function of Posttranscriptional Modifications of Transfer RNAs

(2012) Basma El Yacoubi et al.   Annual Review of Genetics

MODOMICS: a database of RNA modification pathways—2013 update

(2012) Magdalena A. Machnicka et al.   NUCLEIC ACIDS RESEARCH

Human Mitochondrial tRNAs: Biogenesis, Function, Structural Aspects, and Diseases

(2011) Tsutomu Suzuki et al.   Annual Review of Genetics

Maternally Inherited Essential Hypertension Is Associated With the Novel 4263A>G Mutation in the Mitochondrial tRNA Ile Gene in a Large Han Chinese Family

(2011) Shiwen Wang et al.   CIRCULATION RESEARCH

The tRNAMet 4435A>G mutation in the mitochondrial haplogroup G2a1 is responsible for maternally inherited hypertension in a Chinese pedigree

(2011) Zhongqiu Lu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Assessing bioenergetic function in response to oxidative stress by metabolic profiling

(2011) Brian P. Dranka et al.   FREE RADICAL BIOLOGY AND MEDICINE

Determinants of translation efficiency and accuracy

(2011) H. Gingold et al.   Molecular Systems Biology

Nucleotide modifications and tRNA anticodon-mRNA codon interactions on the ribosome

(2011) O. Allner et al.   RNA

Epigenetic Attenuation of Mitochondrial Superoxide Dismutase 2 in Pulmonary Arterial Hypertension

(2010) Stephen L. Archer et al.   CIRCULATION

tRNA biology charges to the front

(2010) E. M. Phizicky et al.   GENES & DEVELOPMENT

Human Mitochondrial Leucyl-tRNA Synthetase Corrects Mitochondrial Dysfunctions Due to the tRNALeu(UUR) A3243G Mutation, Associated with Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Symptoms and Diabetes

(2010) R. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Interaction of Aminoglycosides with Human Mitochondrial 12S rRNA Carrying the Deafness-Associated Mutation

(2009) Y. Qian et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mitochondrial Transfer RNA Met 4435A>G Mutation Is Associated With Maternally Inherited Hypertension in a Chinese Pedigree

(2009) Yuqi Liu et al.   HYPERTENSION

Mitochondria and Reactive Oxygen Species

(2009) Francesco Addabbo et al.   HYPERTENSION

Mistranslation-Induced Protein Misfolding as a Dominant Constraint on Coding-Sequence Evolution

(2008) D. Allan Drummond et al.   CELL

Evaluation of chemiluminescence and flow cytometry as tools in assessing production of hydrogen peroxide and superoxide anion in human spermatozoa

(2008) Reda Mahfouz et al.   FERTILITY AND STERILITY

Eukaryotic Wobble Uridine Modifications Promote a Functionally Redundant Decoding System

(2008) M. J. O. Johansson et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitochondrial tRNAThr G15927A mutation may modulate the phenotypic manifestation of ototoxic 12S rRNA A1555G mutation in four Chinese families

(2008) Xinjian Wang et al.   Pharmacogenetics and Genomics

Crystal structure of archaeal tRNA(m1G37)methyltransferase aTrm5

(2008) Sakurako Goto-Ito et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS