N-Ethylmaleimide increases KCC2 cotransporter activity by modulating transporter phosphorylation

Seizing Control of KCC2: A New Therapeutic Target for Epilepsy

(2017) Yvonne E. Moore et al.   TRENDS IN NEUROSCIENCES

Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay

(2016) Hirotomo Saitsu et al.   Scientific Reports

Activation of the erythroid K-Cl cotransporter Kcc1 enhances sickle cell disease pathology in a humanized mouse model

(2015) Fiona C. Brown et al.   BLOOD

Selective Inhibition of KCC2 Leads to Hyperexcitability and Epileptiform Discharges in Hippocampal Slices and In Vivo

(2015) S. Sivakumaran et al.   JOURNAL OF NEUROSCIENCE

Could tuning of the inhibitory tone involve graded changes in neuronal chloride transport?

(2015) Stefan Titz et al.   NEUROPHARMACOLOGY

KCC2 activity is critical in limiting the onset and severity of status epilepticus

(2015) Liliya Silayeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations in SLC12A5 in epilepsy of infancy with migrating focal seizures

(2015) Tommy Stödberg et al.   Nature Communications

Molecular Mechanism Underlying the Plant NRT1.1 Dual-Affinity Nitrate Transporter

(2015) Ji Sun et al.   Frontiers in Physiology

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+–Cl−co-transporters

(2014) Paola de los Heros et al.   BIOCHEMICAL JOURNAL

Genetically encoded impairment of neuronal KCC2 cotransporter function in human idiopathic generalized epilepsy

(2014) K. T. Kahle et al.   EMBO REPORTS

A Novel Regulatory Locus of Phosphorylation in the C Terminus of the Potassium Chloride Cotransporter KCC2 That Interferes withN-Ethylmaleimide or Staurosporine-mediated Activation

(2014) Maren Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular basis of nitrate uptake by the plant nitrate transporter NRT1.1

(2014) Joanne L. Parker et al.   NATURE

Current view on the functional regulation of the neuronal K+-Cl− cotransporter KCC2

(2014) Igor Medina et al.   Frontiers in Cellular Neuroscience

Enhancing K–Cl co-transport restores normal spinothalamic sensory coding in a neuropathic pain model

(2013) Guillaume Lavertu et al.   BRAIN

Treating pathological pain: is KCC2 the key to the gate?

(2013) Nicolas Doyon et al.   Expert Review of Neurotherapeutics

Modulation of neuronal activity by phosphorylation of the K–Cl cotransporter KCC2

(2013) Kristopher T. Kahle et al.   TRENDS IN NEUROSCIENCES

Regulation of intracellular membrane trafficking and cell dynamics by syntaxin-6

(2012) Jae‑Joon Jung et al.   BIOSCIENCE REPORTS

N-Methyl-d-aspartate Receptor- and Calpain-mediated Proteolytic Cleavage of K+-Cl−Cotransporter-2 Impairs Spinal Chloride Homeostasis in Neuropathic Pain

(2012) Hong-Yi Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cation-chloride cotransporters NKCC1 and KCC2 as potential targets for novel antiepileptic and antiepileptogenic treatments

(2012) Wolfgang Löscher et al.   NEUROPHARMACOLOGY

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

(2011) Jacob O. Thastrup et al.   BIOCHEMICAL JOURNAL

NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor–mediated currents

(2011) Henry H C Lee et al.   NATURE NEUROSCIENCE

On the substrate recognition and negative regulation of SPAK, a kinase modulating Na+-K+-2Cl− cotransport activity

(2010) Kenneth B. Gagnon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Tyrosine phosphorylation regulates the membrane trafficking of the potassium chloride co-transporter KCC2

(2010) Henry H.C. Lee et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chloride regulation in the pain pathway

(2009) Theodore J. Price et al.   BRAIN RESEARCH REVIEWS

Sites of Regulated Phosphorylation that Control K-Cl Cotransporter Activity

(2009) Jesse Rinehart et al.   CELL

Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2

(2009) E. Delpire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

Roles of the cation–chloride cotransporters in neurological disease

(2008) Kristopher T Kahle et al.   Nature clinical practice. Neurology