The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects

Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants

(2017) Abdallah Sayyed-Ahmad et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Ras Conformational Ensembles, Allostery, and Signaling

(2016) Shaoyong Lu et al.   CHEMICAL REVIEWS

The higher level of complexity of K-Ras4B activation at the membrane

(2016) Hyunbum Jang et al.   FASEB JOURNAL

Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions

(2016) Sezen Vatansever et al.   Scientific Reports

Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects

(2015) K. Marcus et al.   CLINICAL CANCER RESEARCH

Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding

(2015) Pamela Y. Ting et al.   FASEB JOURNAL

Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate

(2015) Ryan Knihtila et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ras–Membrane Interface: Isoform-Specific Differences in the Catalytic Domain

(2015) Jillian A. Parker et al.   MOLECULAR CANCER RESEARCH

Differential dynamics of RAS isoforms in GDP- and GTP-bound states

(2015) Abhijeet Kapoor et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD

(2015) Susan K. Fetics et al.   STRUCTURE

Decoding RAS isoform and codon-specific signalling

(2014) Anna U. Newlaczyl et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Integrated RAS signaling defined by parallel NMR detection of effectors and regulators

(2014) Matthew J Smith et al.   Nature Chemical Biology

DRoP: A Water Analysis Program Identifies Ras-GTP-Specific Pathway of Communication between Membrane-Interacting Regions and the Active Site

(2013) Bradley M. Kearney et al.   JOURNAL OF MOLECULAR BIOLOGY

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

(2013) M. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition

(2012) Genevieve Holzapfel et al.   BIOCHEMISTRY

N-Ras Forms Dimers at POPC Membranes

(2012) Jörn Güldenhaupt et al.   BIOPHYSICAL JOURNAL

A Comprehensive Survey of Ras Mutations in Cancer

(2012) I. A. Prior et al.   CANCER RESEARCH

The Ras protein superfamily: Evolutionary tree and role of conserved amino acids

(2012) Ana Maria Rojas et al.   JOURNAL OF CELL BIOLOGY

Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers

(2011) Mitsugu Araki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of Binding Site Hot Spots on the Surface of Ras GTPase

(2011) Greg Buhrman et al.   JOURNAL OF MOLECULAR BIOLOGY

Ras trafficking, localization and compartmentalized signalling

(2011) Ian A. Prior et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis

(2010) Michael Spoerner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

(2010) Greg Buhrman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Allosteric modulation of Ras positions Q61 for a direct role in catalysis

(2010) G. Buhrman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics

(2009) Mohammad T. Mazhab-Jafari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics

(2009) Barry J. Grant et al.   PLoS Computational Biology

Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics

(2008) Jingling Liao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global Conformational Dynamics in Ras†

(2008) Casey O’Connor et al.   BIOCHEMISTRY

The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy

(2008) C. Kotting et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping the Nucleotide and Isoform-Dependent Structural and Dynamical Features of Ras Proteins

(2008) Alemayehu A. Gorfe et al.   STRUCTURE