The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects
出版年份 2017 全文链接
标题
The small GTPases K-Ras, N-Ras, and H-Ras have distinct biochemical properties determined by allosteric effects
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 292, Issue 31, Pages 12981-12993
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2017-06-20
DOI
10.1074/jbc.m117.778886
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Distinct dynamics and interaction patterns in H- and K-Ras oncogenic P-loop mutants
- (2017) Abdallah Sayyed-Ahmad et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Ras Conformational Ensembles, Allostery, and Signaling
- (2016) Shaoyong Lu et al. CHEMICAL REVIEWS
- The higher level of complexity of K-Ras4B activation at the membrane
- (2016) Hyunbum Jang et al. FASEB JOURNAL
- Intrinsic K-Ras dynamics: A novel molecular dynamics data analysis method shows causality between residue pair motions
- (2016) Sezen Vatansever et al. Scientific Reports
- Direct Attack on RAS: Intramolecular Communication and Mutation-Specific Effects
- (2015) K. Marcus et al. CLINICAL CANCER RESEARCH
- Tyrosine phosphorylation of RAS by ABL allosterically enhances effector binding
- (2015) Pamela Y. Ting et al. FASEB JOURNAL
- Neutron Crystal Structure of RAS GTPase Puts in Question the Protonation State of the GTP γ-Phosphate
- (2015) Ryan Knihtila et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ras–Membrane Interface: Isoform-Specific Differences in the Catalytic Domain
- (2015) Jillian A. Parker et al. MOLECULAR CANCER RESEARCH
- Differential dynamics of RAS isoforms in GDP- and GTP-bound states
- (2015) Abhijeet Kapoor et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Allosteric Effects of the Oncogenic RasQ61L Mutant on Raf-RBD
- (2015) Susan K. Fetics et al. STRUCTURE
- Decoding RAS isoform and codon-specific signalling
- (2014) Anna U. Newlaczyl et al. BIOCHEMICAL SOCIETY TRANSACTIONS
- Integrated RAS signaling defined by parallel NMR detection of effectors and regulators
- (2014) Matthew J Smith et al. Nature Chemical Biology
- DRoP: A Water Analysis Program Identifies Ras-GTP-Specific Pathway of Communication between Membrane-Interacting Regions and the Active Site
- (2013) Bradley M. Kearney et al. JOURNAL OF MOLECULAR BIOLOGY
- NMR-based functional profiling of RASopathies and oncogenic RAS mutations
- (2013) M. J. Smith et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Shift in the Equilibrium between On and Off States of the Allosteric Switch in Ras-GppNHp Affected by Small Molecules and Bulk Solvent Composition
- (2012) Genevieve Holzapfel et al. BIOCHEMISTRY
- N-Ras Forms Dimers at POPC Membranes
- (2012) Jörn Güldenhaupt et al. BIOPHYSICAL JOURNAL
- A Comprehensive Survey of Ras Mutations in Cancer
- (2012) I. A. Prior et al. CANCER RESEARCH
- The Ras protein superfamily: Evolutionary tree and role of conserved amino acids
- (2012) Ana Maria Rojas et al. JOURNAL OF CELL BIOLOGY
- Solution Structure of the State 1 Conformer of GTP-bound H-Ras Protein and Distinct Dynamic Properties between the State 1 and State 2 Conformers
- (2011) Mitsugu Araki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Analysis of Binding Site Hot Spots on the Surface of Ras GTPase
- (2011) Greg Buhrman et al. JOURNAL OF MOLECULAR BIOLOGY
- Ras trafficking, localization and compartmentalized signalling
- (2011) Ian A. Prior et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- PHENIX: a comprehensive Python-based system for macromolecular structure solution
- (2010) Paul D. Adams et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Conformational States of Human Rat Sarcoma (Ras) Protein Complexed with Its Natural Ligand GTP and Their Role for Effector Interaction and GTP Hydrolysis
- (2010) Michael Spoerner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase
- (2010) Greg Buhrman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Allosteric modulation of Ras positions Q61 for a direct role in catalysis
- (2010) G. Buhrman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Real-time NMR Study of Three Small GTPases Reveals That Fluorescent 2′(3′)-O-(N-Methylanthraniloyl)-tagged Nucleotides Alter Hydrolysis and Exchange Kinetics
- (2009) Mohammad T. Mazhab-Jafari et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ras Conformational Switching: Simulating Nucleotide-Dependent Conformational Transitions with Accelerated Molecular Dynamics
- (2009) Barry J. Grant et al. PLoS Computational Biology
- Two conformational states of Ras GTPase exhibit differential GTP-binding kinetics
- (2008) Jingling Liao et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Global Conformational Dynamics in Ras†
- (2008) Casey O’Connor et al. BIOCHEMISTRY
- The GAP arginine finger movement into the catalytic site of Ras increases the activation entropy
- (2008) C. Kotting et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mapping the Nucleotide and Isoform-Dependent Structural and Dynamical Features of Ras Proteins
- (2008) Alemayehu A. Gorfe et al. STRUCTURE
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