Cell adhesion controlled by adhesion G protein–coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo–Dock

Gpr124 is essential for blood–brain barrier integrity in central nervous system disease

(2017) Junlei Chang et al.   NATURE MEDICINE

ELMO1 Directly Interacts with Gβγ Subunit to Transduce GPCR Signaling to Rac1 Activation in Chemotaxis

(2016) Youhong Wang et al.   Journal of Cancer

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

The adhesion G protein-coupled receptor G2 (ADGRG2/GPR64) constitutively activates SRE and NFκB and is involved in cell adhesion and migration

(2015) Miriam C. Peeters et al.   CELLULAR SIGNALLING

Intersectin adaptor proteins are associated with actin-regulating protein WIP in invadopodia

(2015) Tetyana Gryaznova et al.   CELLULAR SIGNALLING

Endothelial RhoGEFs: A systematic analysis of their expression profiles in VEGF-stimulated and tumor endothelial cells

(2015) Ricardo Hernández-García et al.   VASCULAR PHARMACOLOGY

GPR124 Functions as a WNT7-Specific Coactivator of Canonical β-Catenin Signaling

(2015) Ekaterina Posokhova et al.   Cell Reports

Oriented Cell Division in the C. elegans Embryo Is Coordinated by G-Protein Signaling Dependent on the Adhesion GPCR LAT-1

(2015) Antje Müller et al.   PLoS Genetics

G-Protein Coupled Receptor 124 (GPR124) in Endothelial Cells Regulates Vascular Endothelial Growth Factor (VEGF)-Induced Tumor Angiogenesis

(2014) Y. Wang et al.   CURRENT MOLECULAR MEDICINE

Gpr124 Controls CNS Angiogenesis and Blood-Brain Barrier Integrity by Promoting Ligand-Specific Canonical Wnt Signaling

(2014) Yulian Zhou et al.   DEVELOPMENTAL CELL

Insights into the biological functions of Dock family guanine nucleotide exchange factors

(2014) M. Laurin et al.   GENES & DEVELOPMENT

Axl Phosphorylates Elmo Scaffold Proteins To Promote Rac Activation and Cell Invasion

(2014) Afnan Abu-Thuraia et al.   MOLECULAR AND CELLULAR BIOLOGY

Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function

(2014) Melanie Barzik et al.   MOLECULAR BIOLOGY OF THE CELL

G-protein coupled receptor BAI3 promotes myoblast fusion in vertebrates

(2014) N. Hamoud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR116, an Adhesion G-Protein-Coupled Receptor, Promotes Breast Cancer Metastasis via the G q-p63RhoGEF-Rho GTPase Pathway

(2013) X. Tang et al.   CANCER RESEARCH

Brain-specific Angiogenesis Inhibitor-1 Signaling, Regulation, and Enrichment in the Postsynaptic Density

(2013) Jason R. Stephenson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of brain endothelial cells by interleukin-1 is regulated by the extracellular matrix after acute brain injury

(2013) Lauren Summers et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease

(2013) D R Cook et al.   ONCOGENE

Small molecule targeting Cdc42–intersectin interaction disrupts Golgi organization and suppresses cell motility

(2013) Amy Friesland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sticky Signaling--Adhesion Class G Protein-Coupled Receptors Take the Stage

(2013) T. Langenhan et al.   Science Signaling

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy

(2013) Cristina Bardita et al.   Jove-Journal of Visualized Experiments

Rho family GTPases

(2012) Alan Hall   BIOCHEMICAL SOCIETY TRANSACTIONS

Angiogenic sprouting into neural tissue requires Gpr124, an orphan G protein-coupled receptor

(2011) K. D. Anderson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR124, an orphan G protein-coupled receptor, is required for CNS-specific vascularization and establishment of the blood-brain barrier

(2011) M. Cullen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Synthetic Biology Approach Reveals a CXCR4-G13-Rho Signaling Axis Driving Transendothelial Migration of Metastatic Breast Cancer Cells

(2011) H. Yagi et al.   Science Signaling

DOCK180 Is a Rac Activator That Regulates Cardiovascular Development by Acting Downstream of CXCR4

(2010) Fumiyuki Sanematsu et al.   CIRCULATION RESEARCH

An Evolutionarily Conserved Autoinhibitory Molecular Switch in ELMO Proteins Regulates Rac Signaling

(2010) Manishha Patel et al.   CURRENT BIOLOGY

The Cdc42 GEF Intersectin 2 controls mitotic spindle orientation to form the lumen during epithelial morphogenesis

(2010) Alejo E. Rodriguez-Fraticelli et al.   JOURNAL OF CELL BIOLOGY

Essential Regulation of CNS Angiogenesis by the Orphan G Protein-Coupled Receptor GPR124

(2010) F. Kuhnert et al.   SCIENCE

Sphingosine-1-phosphate receptor S1P1 is regulated by direct interactions with P-Rex1, a Rac guanine nucleotide exchange factor

(2009) Benjamín Alejandro Ledezma-Sánchez et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structure and Function of Heterotrimeric G Protein-Regulated Rho Guanine Nucleotide Exchange Factors

(2009) M. Aittaleb et al.   MOLECULAR PHARMACOLOGY

Phosphatidylinositol 3,4,5-Triphosphate-Dependent Rac Exchanger 1 (P-Rex-1), a Guanine Nucleotide Exchange Factor for Rac, Mediates Angiogenic Responses to Stromal Cell-Derived Factor-1/Chemokine Stromal Cell Derived Factor-1 (SDF-1/CXCL-12) Linked to Rac Activation, Endothelial Cell Migration, and in Vitro Angiogenesis

(2009) J. Carretero-Ortega et al.   MOLECULAR PHARMACOLOGY

Driving Rho GTPase activity in endothelial cells regulates barrier integrity

(2009) C. M. L. Beckers et al.   THROMBOSIS AND HAEMOSTASIS

Orphan G Protein-coupled Receptor GPR56 Regulates Neural Progenitor Cell Migration via a Gα12/13 and Rho Pathway

(2008) Tokuichi Iguchi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY