C/EBPα transcription factor is regulated by the RANK cytoplasmic535IVVY538motif and stimulates osteoclastogenesis more strongly than c-Fos

Cbfβ governs osteoblast−adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression

(2017) Mengrui Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CCAAT/Enhancer-binding Protein α (C/EBPα) Is Important for Osteoclast Differentiation and Activity

(2016) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The IVVY Motif and Tumor Necrosis Factor Receptor-associated Factor (TRAF) Sites in the Cytoplasmic Domain of the Receptor Activator of Nuclear Factor κB (RANK) Cooperate to Induce Osteoclastogenesis

(2015) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DNA Methylation of a GC Repressor Element in the Smooth Muscle Myosin Heavy Chain Promoter Facilitates Binding of the Notch-Associated Transcription Factor, RBPJ/CSL1

(2014) Julian M. Rozenberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Core Binding Factor Beta (Cbfβ) Controls the Balance of Chondrocyte Proliferation and Differentiation by Upregulating Indian hedgehog (Ihh) Expression and Inhibiting Parathyroid Hormone-Related Protein Receptor (PPR) Expression in Postnatal Cartilage and

(2014) Fei Tian et al.   JOURNAL OF BONE AND MINERAL RESEARCH

RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis

(2014) Susan Li et al.   JOURNAL OF CLINICAL INVESTIGATION

RANK receptor oligomerisation in the regulation of NF B signalling

(2014) S. Das et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Osteopetrosis in TAK1-deficient mice owing to defective NF-κB and NOTCH signaling

(2014) Gaurav Swarnkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cbf  deletion in mice recapitulates cleidocranial dysplasia and reveals multiple functions of Cbf  required for skeletal development

(2014) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of Rgs10 Expression Prevents Immune Cell Infiltration in Bacteria-induced Inflammatory Lesions and Osteoclast-mediated Bone Destruction

(2014) Sen Yang et al.   Bone Research

C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence

(2013) Min Ye et al.   NATURE CELL BIOLOGY

C/EBP  regulates osteoclast lineage commitment

(2013) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Requirement of Receptor Activator of Nuclear Factor κB Signaling for Interleukin 1-mediated Osteoclastogenesis

(2012) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

V-ATPase subunit ATP6AP1 (Ac45) regulates osteoclast differentiation, extracellular acidification, lysosomal trafficking, and protease exocytosis in osteoclast-mediated bone resorption

(2012) De-Qin Yang et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression ofSox9

(2012) Shan Chen et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J

(2012) Baohong Zhao et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Disruption of the transcription factor RBP-J results in osteopenia attributable to attenuated osteoclast differentiation

(2012) Jing Ma et al.   MOLECULAR BIOLOGY REPORTS

Disorders of Bone Remodeling

(2011) Xu Feng et al.   Annual Review of Pathology-Mechanisms of Disease

Negative regulation of osteoclastogenesis and bone resorption by cytokines and transcriptional repressors

(2011) Baohong Zhao et al.   ARTHRITIS RESEARCH & THERAPY

Development of Cell-Based High-Throughput Assays for the Identification of Inhibitors of Receptor Activator of Nuclear Factor-Kappa B Signaling

(2010) Jason W. Ashley et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Receptor Activator of NF-κB (RANK) Cytoplasmic IVVY535–538Motif Plays an Essential Role in Tumor Necrosis Factor-α (TNF)-mediated Osteoclastogenesis

(2010) Joel Jules et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas

(2010) Yi-Ping Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Interferon regulatory factor-8 suppresses osteoclastogenesis

(2010) Hermann Wagner   Nature Reviews Rheumatology

A unique domain in RANK is required for Gab2 and PLCγ2 binding to establish osteoclastogenic signals

(2009) Yuu Taguchi et al.   GENES TO CELLS

Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice

(2009) Hyunsoo Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Interferon regulatory factor-8 regulates bone metabolism by suppressing osteoclastogenesis

(2009) Baohong Zhao et al.   NATURE MEDICINE

Human Osteoclast-Poor Osteopetrosis with Hypogammaglobulinemia due to TNFRSF11A (RANK) Mutations

(2008) Matteo M. Guerrini et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Atp6v1c1 is an essential component of the osteoclast proton pump and in F-actin ring formation in osteoclasts

(2008) Shengmei Feng et al.   BIOCHEMICAL JOURNAL

RBP-Jκ binds to and represses transcription of the p53 tumor suppressor gene

(2008) Kristy Boggs et al.   CELL BIOLOGY INTERNATIONAL

Atp6v0d2 Is an Essential Component of the Osteoclast-Specific Proton Pump That Mediates Extracellular Acidification in Bone Resorption

(2008) Haiping Wu et al.   JOURNAL OF BONE AND MINERAL RESEARCH