The CDC50A extracellular domain is required for forming a functional complex with and chaperoning phospholipid flippases to the plasma membrane

Loss of Tmem30a leads to photoreceptor degeneration

(2017) Lin Zhang et al.   Scientific Reports

Role of post-translational modifications at the  -subunit ectodomain in complex association with a promiscuous plant P4-ATPase

(2016) S. R. Costa et al.   BIOCHEMICAL JOURNAL

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia

(2016) N. Arashiki et al.   HAEMATOLOGICA

Getting membrane proteins on and off the shuttle bus between the endoplasmic reticulum and the Golgi complex

(2016) Nica Borgese   JOURNAL OF CELL SCIENCE

Getting to the Outer Leaflet: Physiology of Phosphatidylserine Exposure at the Plasma Membrane

(2016) Edouard M. Bevers et al.   PHYSIOLOGICAL REVIEWS

Xkr8 phospholipid scrambling complex in apoptotic phosphatidylserine exposure

(2016) Jun Suzuki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia

(2016) N. Arashiki et al.   HAEMATOLOGICA

P4-ATPases as Phospholipid Flippases—Structure, Function, and Enigmas

(2016) Jens P. Andersen et al.   Frontiers in Physiology

ATP11C Facilitates Phospholipid Translocation across the Plasma Membrane of All Leukocytes

(2016) Mehmet Yabas et al.   PLoS One

Specific mutations in mammalian P4-ATPase ATP8A2 catalytic subunit entail differential glycosylation of the accessory CDC50A subunit

(2015) Anna L. Vestergaard et al.   FEBS LETTERS

Rational Protein Engineering Guided by Deep Mutational Scanning

(2015) HyeonSeok Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Human Type IV P-type ATPases That Work as Plasma Membrane Phospholipid Flippases and Their Regulation by Caspase and Calcium

(2015) Katsumori Segawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional role of evolutionarily highly conserved residues, N-glycosylation level and domains of theLeishmaniamiltefosine transporter-Cdc50 subunit

(2014) Sebastián García-Sánchez et al.   BIOCHEMICAL JOURNAL

Mice Deficient in the Putative Phospholipid Flippase ATP11C Exhibit Altered Erythrocyte Shape, Anemia, and Reduced Erythrocyte Life Span

(2014) Mehmet Yabas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipid Flippase Activities and Substrate Specificities of Human Type IV P-type ATPases Localized to the Plasma Membrane

(2014) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Measuring the activity of protein variants on a large scale using deep mutational scanning

(2014) Douglas M Fowler et al.   Nature Protocols

Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure

(2014) K. Segawa et al.   SCIENCE

Role of Flippases, Scramblases and Transfer Proteins in Phosphatidylserine Subcellular Distribution

(2014) Hannah M. Hankins et al.   TRAFFIC

Vesicle-mediated export from the ER: COPII coat function and regulation

(2013) Jennifer G. D'Arcangelo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

New crystal structures of PII-type ATPases: excitement continues

(2013) Chikashi Toyoshima et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Coupling mutagenesis and parallel deep sequencing to probe essential residues in a genome or gene

(2013) William P. Robins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mapping Functional Interactions in a Heterodimeric Phospholipid Pump

(2012) Catheleyne F. Puts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Isolation and characterization of novel mutations in CDC50, the non-catalytic subunit of the Drs2p phospholipid flippase

(2011) Y. Takahashi et al.   JOURNAL OF BIOCHEMISTRY

ATP9B, a P4-ATPase (a Putative Aminophospholipid Translocase), Localizes to thetrans-Golgi Network in a CDC50 Protein-independent Manner

(2011) Hiroyuki Takatsu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of the β-Subunit CDC50A in the Stable Expression, Assembly, Subcellular Localization, and Lipid Transport Activity of the P4-ATPase ATP8A2

(2011) Jonathan A. Coleman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Platelet membrane phospholipid asymmetry: from the characterization of a scramblase activity to the identification of an essential protein mutated in Scott syndrome

(2011) T. LHERMUSIER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

A simplified polyethylenimine-mediated transfection process for large-scale and high-throughput applications

(2011) Céline Raymond et al.   METHODS

Golgi Glycosylation

(2011) P. Stanley   Cold Spring Harbor Perspectives in Biology

The Distribution and Function of Phosphatidylserine in Cellular Membranes

(2010) Peter A. Leventis et al.   Annual Review of Biophysics

Fast and accurate long-read alignment with Burrows–Wheeler transform

(2010) Heng Li et al.   BIOINFORMATICS

Autoimmunity and the Clearance of Dead Cells

(2010) Shigekazu Nagata et al.   CELL

Random Mutagenesis Methods for In Vitro Directed Enzyme Evolution

(2010) Nikolaos Labrou   CURRENT PROTEIN & PEPTIDE SCIENCE

CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery

(2010) Susanne Bryde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intracellular Targeting Signals and Lipid Specificity Determinants of the ALA/ALIS P4-ATPase Complex Reside in the Catalytic ALA α-Subunit

(2010) Rosa L. López-Marqués et al.   MOLECULAR BIOLOGY OF THE CELL

Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p

(2009) Guillaume Lenoir et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane lipids: where they are and how they behave

(2008) Gerrit van Meer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY