State of Play in Alzheimer’s Disease Genetics

Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

(2017) Matthias Brendel et al.   Frontiers in Aging Neuroscience

Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease

(2017) Erin L. Heinzen et al.   JOURNAL OF ALZHEIMERS DISEASE

TREM2 Function in Alzheimer’s Disease and Neurodegeneration

(2016) Jason D. Ulrich et al.   ACS Chemical Neuroscience

Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease

(2016) Allen Roses et al.   Alzheimers & Dementia

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

Cerebrospinal fluid-induced retardation of amyloid β aggregation correlates with Alzheimer's disease and the APOE ε4 allele

(2016) E.R. Padayachee et al.   BRAIN RESEARCH

Editorial (Thematic Issue: Towards New Approaches in Alzheimer's Research and Alzheimer's Disease)

(2016) Sabine Mai   Current Alzheimer Research

TREM2 p.H157Y Variant and the Risk of Alzheimer's Disease: A Meta-Analysis Involving 14,510 Subjects

(2016) Teng Jiang et al.   CURRENT NEUROVASCULAR RESEARCH

Microtubule-Tau Interaction as a Therapeutic Target for Alzheimer’s Disease

(2016) Yanina Ivashko Pachima et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Genetic variations underlying Alzheimer's disease: evidence from genome-wide association studies and beyond

(2016) Elise Cuyvers et al.   LANCET NEUROLOGY

SORL1 Is Associated with the Risk of Late-Onset Alzheimer’s Disease: a Replication Study and Meta-Analyses

(2016) Cheng-Cheng Zhang et al.   MOLECULAR NEUROBIOLOGY

Endogenous Apolipoprotein E (ApoE) Fragmentation Is Linked to Amyloid Pathology in Transgenic Mouse Models of Alzheimer’s Disease

(2016) Anika Saul et al.   MOLECULAR NEUROBIOLOGY

Effect of CR1 Genetic Variants on Cerebrospinal Fluid and Neuroimaging Biomarkers in Healthy, Mild Cognitive Impairment and Alzheimer's Disease Cohorts

(2016) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

TREM2 Overexpression has No Improvement on Neuropathology and Cognitive Impairment in Aging APPswe/PS1dE9 Mice

(2016) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Family-based association analyses of imputed genotypes reveal genome-wide significant association of Alzheimer’s disease with OSBPL6, PTPRG and PDCL3

(2016) C Herold et al.   MOLECULAR PSYCHIATRY

ABCA7 p.G215S as potential protective factor for Alzheimer's disease

(2016) Celeste Sassi et al.   NEUROBIOLOGY OF AGING

A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

(2016) Teng Jiang et al.   NEUROBIOLOGY OF AGING

The TOMM40 gene rs2075650 polymorphism contributes to Alzheimer’s disease in Caucasian, and Asian populations

(2016) Hao Huang et al.   NEUROSCIENCE LETTERS

An Overview of Genome-Wide Association Studies in Alzheimer’s Disease

(2016) Luxi Shen et al.   Neuroscience Bulletin

Effect of CLU genetic variants on cerebrospinal fluid and neuroimaging markers in healthy, mild cognitive impairment and Alzheimer’s disease cohorts

(2016) Lin Tan et al.   Scientific Reports

Rare Functional Variant in TM2D3 is Associated with Late-Onset Alzheimer's Disease

(2016) Johanna Jakobsdottir et al.   PLoS Genetics

Alzheimer’s Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci

(2016) Celeste M. Karch et al.   PLoS One

Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion

(2015) Florence F. Roussotte et al.   Alzheimers & Dementia

APOE effect on Alzheimer's disease biomarkers in older adults with significant memory concern

(2015) Shannon L. Risacher et al.   Alzheimers & Dementia

A 22-single nucleotide polymorphism Alzheimer's disease risk score correlates with family history, onset age, and cerebrospinal fluid Aβ 42

(2015) Kristel Sleegers et al.   Alzheimers & Dementia

Convergent genetic and expression data implicate immunity in Alzheimer's disease

(2015) Lesley Jones et al.   Alzheimers & Dementia

Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans

(2015) Andrew J. Saykin et al.   Alzheimers & Dementia

Coding mutations inSORL1and Alzheimer disease

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Rare coding mutations identified by sequencing of Alzheimer disease genome-wide association studies loci

(2015) Badri N. Vardarajan et al.   ANNALS OF NEUROLOGY

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

Elucidating Molecular Phenotypes Caused by the SORL1 Alzheimer’s Disease Genetic Risk Factor Using Human Induced Pluripotent Stem Cells

(2015) Jessica E. Young et al.   Cell Stem Cell

Alzheimer’s Disease: Lessons Learned from Amyloidocentric Clinical Trials

(2015) Andreas Soejitno et al.   CNS DRUGS

Alzheimer's disease: rare variants with large effect sizes

(2015) Jorge L Del-Aguila et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Inverse effect of the APOE epsilon4 allele in late- and early-onset Alzheimer’s disease

(2015) Vincenzo De Luca et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

The genetic landscape of Alzheimer disease: clinical implications and perspectives

(2015) Caroline Van Cauwenberghe et al.   GENETICS IN MEDICINE

Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

(2015) Keith A. Vossel et al.   JOURNAL OF CELL BIOLOGY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Meta-analysis of the Association between Alzheimer Disease and Variants in GAB2, PICALM, and SORL1

(2015) Ziran Wang et al.   MOLECULAR NEUROBIOLOGY

The Impact of UNC5C Genetic Variations on Neuroimaging in Alzheimer’s Disease

(2015) Jia-Hao Sun et al.   MOLECULAR NEUROBIOLOGY

Impact of Common Variations in PLD3 on Neuroimaging Phenotypes in Non-demented Elders

(2015) Chong Wang et al.   MOLECULAR NEUROBIOLOGY

PLD3 in Alzheimer’s Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses

(2015) Deng-Feng Zhang et al.   MOLECULAR NEUROBIOLOGY

Multiple Effect of APOE Genotype on Clinical and Neuroimaging Biomarkers Across Alzheimer’s Disease Spectrum

(2015) Ying Liu et al.   MOLECULAR NEUROBIOLOGY

η-Secretase processing of APP inhibits neuronal activity in the hippocampus

(2015) Michael Willem et al.   NATURE

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

(2015) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Defining the Genetic Architecture of Alzheimer's Disease: Where Next?

(2015) Rebecca Sims et al.   Neurodegenerative Diseases

Genetic Association Between APP, ADAM10 Gene Polymorphism, and Sporadic Alzheimer’s Disease in the Chinese Population

(2015) Fan Zeng et al.   NEUROTOXICITY RESEARCH

Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease

(2015) Jon B. Toledo et al.   JAMA Neurology

Genetic modification of the relationship between phosphorylated tau and neurodegeneration

(2014) Timothy J. Hohman et al.   Alzheimers & Dementia

Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans

(2014) Mark W. Logue et al.   Alzheimers & Dementia

Extension and refinement of the predictive value of different classes of markers in ADNI: Four-year follow-up data

(2014) Jesus J. Gomar et al.   Alzheimers & Dementia

PLXNA4is associated with Alzheimer disease and modulates tau phosphorylation

(2014) Gyungah Jun et al.   ANNALS OF NEUROLOGY

Transcriptome-guided amyloid imaging genetic analysis via a novel structured sparse learning algorithm

(2014) J. Yan et al.   BIOINFORMATICS

Clinical and Neuroimaging Characterization of Chinese Dementia Patients with PSEN1 and PSEN2 Mutations

(2014) Zhihong Shi et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

SUCLG2 identified as both a determinator of CSF Aβ1–42 levels and an attenuator of cognitive decline in Alzheimer's disease

(2014) Alfredo Ramirez et al.   HUMAN MOLECULAR GENETICS

Pathways to Alzheimer's disease

(2014) J. Hardy et al.   JOURNAL OF INTERNAL MEDICINE

APOE genotype and neuroimaging markers of Alzheimer's disease: systematic review and meta-analysis

(2014) Y. Liu et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Combined Effects of Alzheimer Risk Variants in the CLU and ApoE Genes on Ventricular Expansion Patterns in the Elderly

(2014) F. F. Roussotte et al.   JOURNAL OF NEUROSCIENCE

CR1 in Alzheimer's Disease

(2014) Xi-Chen Zhu et al.   MOLECULAR NEUROBIOLOGY

PLD3 in Alzheimer’s Disease

(2014) Jun Wang et al.   MOLECULAR NEUROBIOLOGY

The Role of SORL1 in Alzheimer’s Disease

(2014) Rui-Hua Yin et al.   MOLECULAR NEUROBIOLOGY

Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2

(2014) Jason D Ulrich et al.   Molecular Neurodegeneration

A genome-wide association meta-analysis of plasma Aβ peptides concentrations in the elderly

(2014) V Chouraki et al.   MOLECULAR PSYCHIATRY

A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death

(2014) Monica K Wetzel-Smith et al.   NATURE MEDICINE

Investigation of TREM2, PLD3, and UNC5C variants in patients with Alzheimer's disease from mainland China

(2014) Bin Jiao et al.   NEUROBIOLOGY OF AGING

Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals

(2014) Meng-Shan Tan et al.   NEUROBIOLOGY OF AGING

Serum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure

(2014) Nicholus M. Warstadt et al.   NEUROBIOLOGY OF AGING

Frontobasal gray matter loss is associated with the TREM2 p.R47H variant

(2014) Elkin O. Luis et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease Genetics: From the Bench to the Clinic

(2014) Celeste M. Karch et al.   NEURON

Association between NME8 Locus Polymorphism and Cognitive Decline, Cerebrospinal Fluid and Neuroimaging Biomarkers in Alzheimer's Disease

(2014) Ying Liu et al.   PLoS One

A single nucleotide polymorphism associated with reduced alcohol intake in the RASGRF2 gene predicts larger cortical volumes but faster longitudinal ventricular expansion in the elderly

(2014) Florence Roussotte   Frontiers in Aging Neuroscience

The role of apolipoprotein E (APOE) genotype in early mild cognitive impairment (E-MCI)

(2014) Shannon Risacher   Frontiers in Aging Neuroscience

Genetic variation modifies risk for neurodegeneration based on biomarker status

(2014) Timothy J. Hohman et al.   Frontiers in Aging Neuroscience

Identification of rare variants in Alzheimer’s disease

(2014) Jenny Lord et al.   Frontiers in Genetics

Association of plasma and cortical amyloid beta is modulated by APOE ε4 status

(2013) Shanker Swaminathan et al.   Alzheimers & Dementia

Genetic analysis of quantitative phenotypes in AD and MCI: imaging, cognition and biomarkers

(2013) Li Shen et al.   Brain Imaging and Behavior

SnapShot: Genetics of Alzheimer’s Disease

(2013) Rita Guerreiro et al.   CELL

A commonly carried genetic variant in the delta opioid receptor gene,OPRD1,is associated with smaller regional brain volumes: Replication in elderly and young populations

(2013) Florence F. Roussotte et al.   HUMAN BRAIN MAPPING

Variants in the ATP-Binding Cassette Transporter (ABCA7), Apolipoprotein E ϵ4, and the Risk of Late-Onset Alzheimer Disease in African Americans

(2013) Christiane Reitz et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese

(2013) Rui-Chun Lu et al.   JOURNAL OF NEURAL TRANSMISSION

CD33 in Alzheimer's Disease

(2013) Teng Jiang et al.   MOLECULAR NEUROBIOLOGY

Increased expression of BIN1 mediates Alzheimer genetic risk by modulating tau pathology

(2013) J Chapuis et al.   MOLECULAR PSYCHIATRY

APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study

(2013) V K Ramanan et al.   MOLECULAR PSYCHIATRY

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Missense variants in CR1 are associated with increased risk of Alzheimer' disease in Han Chinese

(2013) Xiao-Ying Ma et al.   NEUROBIOLOGY OF AGING

Genetic variation in PICALM and Alzheimer's disease risk in Han Chinese

(2013) Teng Jiang et al.   NEUROBIOLOGY OF AGING

Interactions between GSK3β and amyloid genes explain variance in amyloid burden

(2013) Timothy J. Hohman et al.   NEUROBIOLOGY OF AGING

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth

(2013) Kelly R. Murphy et al.   NEUROIMAGE

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

(2013) Jared B. Vasquez et al.   NEUROSCIENCE LETTERS

Genetic Loci Associated with Alzheimer’s Disease and Cerebrospinal Fluid Biomarkers in a Finnish Case-Control Cohort

(2013) Lyzel S. Elias-Sonnenschein et al.   PLoS One

Association between an Alzheimer’s Disease-Related Index and APOE ε4 Gene Dose

(2013) Frank Schraml et al.   PLoS One

Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity

(2013) N. Jahanshad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy

(2013) Y. Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence for impaired amyloid β clearance in Alzheimer's disease

(2013) Kristin R Wildsmith et al.   Alzheimers Research & Therapy

Genetic Susceptibility for Alzheimer Disease Neuritic Plaque Pathology

(2013) Joshua M. Shulman et al.   JAMA Neurology

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease

(2012) Carlos Cruchaga et al.   HUMAN MOLECULAR GENETICS

Role of Phosphatidylinositol Clathrin Assembly Lymphoid-Myeloid Leukemia (PICALM) in Intracellular Amyloid Precursor Protein (APP) Processing and Amyloid Plaque Pathogenesis

(2012) Qingli Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer’s disease

(2012) E. Rodríguez-Rodríguez et al.   JOURNAL OF NEURAL TRANSMISSION

APOE4 predicts amyloid-β in cortical brain biopsy but not idiopathic normal pressure hydrocephalus

(2012) Okko T Pyykkö et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

(2012) C Pottier et al.   MOLECULAR PSYCHIATRY

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

(2012) J-C Lambert et al.   MOLECULAR PSYCHIATRY

A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline

(2012) Thorlakur Jonsson et al.   NATURE

A large scale multivariate parallel ICA method reveals novel imaging–genetic relationships for Alzheimer's disease in the ADNI cohort

(2012) Shashwath A. Meda et al.   NEUROIMAGE

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rare Variants in APP, PSEN1 and PSEN2 Increase Risk for AD in Late-Onset Alzheimer's Disease Families

(2012) Carlos Cruchaga et al.   PLoS One

Expression of Novel Alzheimer’s Disease Risk Genes in Control and Alzheimer’s Disease Brains

(2012) Celeste M. Karch et al.   PLoS One

Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort

(2012) Sheng Jin et al.   Alzheimers Research & Therapy

Genome-wide association study of Alzheimer's disease

(2012) M I Kamboh et al.   Translational Psychiatry

A Comprehensive Genetic Association Study of Alzheimer Disease in African Americans

(2011) Mark W. Logue   ARCHIVES OF NEUROLOGY

Amyloid pathway-based candidate gene analysis of [11C]PiB-PET in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort

(2011) Shanker Swaminathan et al.   Brain Imaging and Behavior

Genetic association between ADAM10 gene polymorphism and Alzheimer's disease in a Northern Han Chinese population

(2011) Jing-Hui Song et al.   BRAIN RESEARCH

Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

(2011) Vanessa Schmidt et al.   EMBO JOURNAL

Genome-wide association study of Alzheimer's disease with psychotic symptoms

(2011) P Hollingworth et al.   MOLECULAR PSYCHIATRY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Evidence of the association of BIN1 and PICALM with the AD risk in contrasting European populations

(2011) Jean-Charles Lambert et al.   NEUROBIOLOGY OF AGING

Meta-Analysis for Genome-Wide Association Study Identifies Multiple Variants at the BIN1 Locus Associated with Late-Onset Alzheimer's Disease

(2011) Xiaolan Hu et al.   PLoS One

Fine Mapping of Genetic Variants in BIN1, CLU, CR1 and PICALM for Association with Cerebrospinal Fluid Biomarkers for Alzheimer's Disease

(2011) John S. K. Kauwe et al.   PLoS One

Functional Links Between A  Toxicity, Endocytic Trafficking, and Alzheimer's Disease Risk Factors in Yeast

(2011) S. Treusch et al.   SCIENCE

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Genome-Wide Association of Familial Late-Onset Alzheimer's Disease Replicates BIN1 and CLU and Nominates CUGBP2 in Interaction with APOE

(2011) Ellen M. Wijsman et al.   PLoS Genetics

Genetic Variation and Neuroimaging Measures in Alzheimer Disease

(2010) Alessandro Biffi   ARCHIVES OF NEUROLOGY

Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals

(2010) Joseph H. Lee et al.   ARCHIVES OF NEUROLOGY

Genome-wide association reveals genetic effects on human Aβ 42 and τ protein levels in cerebrospinal fluids: a case control study

(2010) Mi-Ryung Han et al.   BMC Neurology

Alzheimer’s disease phenotypes and genotypes associated with mutations in presenilin 2

(2010) Suman Jayadev et al.   BRAIN

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Implication of CLU gene polymorphisms in Chinese patients with Alzheimer's disease

(2010) Jin-Tai Yu et al.   CLINICA CHIMICA ACTA

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

(2010) Jason J. Corneveaux et al.   HUMAN MOLECULAR GENETICS

Genome-wide Analysis of Genetic Loci Associated With Alzheimer Disease

(2010) Sudha Seshadri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Distribution and Expression of Picalm in Alzheimer Disease

(2010) Shabnam Baig et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic association of PICALM polymorphisms with Alzheimer's disease in Han Chinese

(2010) Jin-Tai Yu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

γ-secretases: from cell biology to therapeutic strategies

(2010) Bruno A Bergmans et al.   LANCET NEUROLOGY

Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease

(2010) S J Furney et al.   MOLECULAR PSYCHIATRY

Alzheimer disease pathology in cognitively healthy elderly: A genome-wide study

(2010) Patricia L. Kramer et al.   NEUROBIOLOGY OF AGING

The genetic architecture of Alzheimer's disease: beyond APP, PSENs and APOE

(2010) Rita J. Guerreiro et al.   NEUROBIOLOGY OF AGING

Genome-wide association study of CSF biomarkers A 1-42, t-tau, and p-tau181p in the ADNI cohort

(2010) S. Kim et al.   NEUROLOGY

Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities

(2010) Adam C. Naj et al.   PLoS Genetics

Genome-wide Association Study Implicates a Chromosome 12 Risk Locus for Late-Onset Alzheimer Disease

(2009) Gary W. Beecham et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

(2009) Minji Kim et al.   HUMAN MOLECULAR GENETICS

The structure, genetic polymorphisms, expression and biological functions of complement receptor type 1 (CR1/CD35)

(2009) Dong Liu et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Examination of the current top candidate genes for AD in a genome-wide association study

(2009) T M Feulner et al.   MOLECULAR PSYCHIATRY

Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease

(2009) Minerva M Carrasquillo et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

(2009) S. Salloway et al.   NEUROLOGY

A Recessive Mutation in the APP Gene with Dominant-Negative Effect on Amyloidogenesis

(2009) G. Di Fede et al.   SCIENCE

Genome-wide Association Analysis Reveals Putative Alzheimer's Disease Susceptibility Loci in Addition to APOE

(2008) Lars Bertram et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Genome screen of late-onset Alzheimer's extended pedigrees identifies TRPC4AP by haplotype analysis

(2008) S.E. Poduslo et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

(2008) Richard Abraham et al.   BMC Medical Genomics

The membrane-tubulating potential of amphiphysin 2/BIN1 is dependent on the microtubule-binding cytoplasmic linker protein 170 (CLIP-170)

(2008) Brigitte Meunier et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding cassette transporter A7 regulates processing of amyloid precursor proteinin vitro

(2008) Sharon L. Chan et al.   JOURNAL OF NEUROCHEMISTRY

Clathrin Assembly Protein AP180 and CALM Differentially Control Axogenesis and Dendrite Outgrowth in Embryonic Hippocampal Neurons

(2008) I. Bushlin et al.   JOURNAL OF NEUROSCIENCE

Comparative proteomic analysis of brains of naturally aging mice

(2008) S. Yang et al.   NEUROSCIENCE

Evidence for CALM in Directing VAMP2 Trafficking

(2008) Asaff Harel et al.   TRAFFIC

Candidate Single-Nucleotide Polymorphisms From a Genomewide Association Study of Alzheimer Disease

(2007) Hao Li et al.   ARCHIVES OF NEUROLOGY