Article
Plant Sciences
Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang, Sen Zhang
Summary: The study evaluates the renal protective effect of esculetin against the progression of lupus nephritis and finds that esculetin can significantly improve renal function and pathology. It exhibits antioxidant and anti-inflammatory properties and acts on LN through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Evan P. Stater, Ali Y. Sonay, Cassidy Hart, Jan Grimm
Summary: Nanoparticles, beyond their engineered functions, can induce specific biological effects, which may have implications for the development and clinical application of nanomedicine.
NATURE NANOTECHNOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Yuan Liu, Junqing Wang, Qingqing Xiong, Daniel Hornburg, Wei Tao, Omid C. Farokhzad
Summary: Understanding the interactions between nanomaterials and biological systems is crucial for improving the efficacy of nanomedicine and advancing disease diagnosis. The nanoparticle-protein corona has a decisive effect on the in vivo fate of nanomedicine and can be used to enrich low-abundance proteins for biomarker discovery.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Immunology
Jonathan Barratt, Ilene Weitz
Summary: The complement system is crucial for defending against pathogens, but dysregulation can lead to autoimmune diseases. The alternative complement pathway plays a key role in amplifying activation. Factor D, a serine protease in this pathway, is essential for C3 convertase formation and is a potential therapeutic target for diseases involving excessive complement activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Anna Schubart, Stefanie Flohr, Tobias Junt, Joerg Eder
Summary: Dysregulation of the alternative complement pathway can lead to various diseases, and inhibitors targeting central proteases of the pathway are being developed as therapeutics. These inhibitors have the potential to treat complement-mediated diseases in both systemic and peripheral tissues, and may also be effective in inhibiting complement activation in the central nervous system.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Immunology
Alexandra Gerogianni, Melissa Bal, Camilla Mohlin, Trent M. M. Woodruff, John D. D. Lambris, Tom E. E. Mollnes, Dick J. J. Sjostrom, Per H. H. Nilsson
Summary: Iron oxide nanoparticles (IONPs) are widely used in diagnostic and therapeutic settings, but they can be recognized by the innate immune system upon systemic administration, limiting their therapeutic capacity and causing potential adverse side effects. This study investigated the thromboinflammatory response of IONPs in anticoagulated whole blood, and found that they induced complement activation and a strong release of cytokines. They also caused cell activation and showed cytotoxic effects, but these responses were partly complement-dependent and could be attenuated by complement inhibition.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Margrethe Flesvig Holt, Annika E. Michelsen, Negar Shahini, Elisabeth Bjorkelund, Christina Holt Bendz, Richard J. Massey, Camilla Schjalm, Bente Halvorsen, Kaspar Broch, Thor Ueland, Lars Gullestad, Per H. Nilsson, Pal Aukrust, Tom Eirik Mollnes, Mieke C. Louwe
Summary: In patients with heart failure, the alternative pathway of the complement system is activated, but not the terminal pathway. Plasma levels of factor B and C3 convertase C3bBbP are elevated in these patients, but not associated with mortality during follow-up.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Yadileiny Portilla, Vladimir Mulens-Arias, Neus Daviu, Alberto Paradela, Sonia Perez-Yague, Domingo F. Barber
Summary: When iron oxide nanoparticles (IONPs) come into contact with biological fluids, they form protein corona complexes that vary in composition based on the origin of the serum. These complexes have an impact on the interaction between IONPs and macrophages, ultimately affecting the immune system.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jie Zhou, Hongjin Xiang, Jianbo Huang, Yi Zhong, Xiaoxia Zhu, Jinshun Xu, Qiang Lu, Binyang Gao, Huan Zhang, Rui Yang, Yan Luo, Feng Yan
Summary: The study shows that charged Nano-UCAs have a higher likelihood of activating the complement system and being efficiently engulfed by macrophages.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Masoumeh Jomhori Baloch, Hamid Mosaddeghi, Majid Jamshidian-Mojaver
Summary: This study investigates the interaction mechanisms between insulin and different sizes of copper nanoparticles using molecular dynamics simulations, revealing significant impacts of nanoparticle size on interaction energy and insulin secondary structure.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Nanoscience & Nanotechnology
Harald Unterweger, Christina Janko, Tamara Folk, Iwona Cicha, Noemi Kovacs, Gyula Gyebnar, Ildiko Horvath, Domokos Mathe, Kang H. Zheng, Bram F. Coolen, Erik Stroes, Janos Szebeni, Christoph Alexiou, Laszlo Dezsi, Stefan Lyer
Summary: This study compared a new iron oxide-based contrast agent, SPIONDex, with conventional contrast agents ferucarbotran and ferumoxytol. The results demonstrate that SPIONDex has better biocompatibility and immunocompatibility, and does not trigger allergic reactions. In a rat model, SPIONDex showed liver imaging properties comparable to the other two agents but with faster clearance. These findings suggest that SPIONDex is a promising candidate for further clinical translation.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Review
Pharmacology & Pharmacy
Chen Guo, Haoyang Yuan, Yuxiu Wang, Yupeng Feng, Yu Zhang, Tian Yin, Haibing He, Jingxin Gou, Xing Tang
Summary: During the past two decades, it has been revealed that the immunogenicity of polyethylene glycol (PEG) can lead to accelerated blood clearance (ABC) and hypersensitivity reaction (HSR) to PEGylated nanoparticles, which can potentially undermine their effectiveness and pose life-threatening risks to patients. Therefore, a better understanding of the interaction between PEGylated nanoparticles and the immune system is crucial in developing and implementing related formulations. This review summarizes the physiological mechanisms of PEG-specific immune response and explores the potential relationship between the induction phase and the effectuation phase, providing insights into the conflicting results observed in published reports. Furthermore, the role of nanoparticle-associated factors is discussed, aiding researchers in developing PEGylated nanoparticles with improved immune response profiles based on underlying mechanisms.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Alexander J. Plant-Hately, Burcu Eryilmaz, Christopher A. W. David, Danielle E. Brain, Bethany J. Heaton, Yvonne Perrie, Neill J. Liptrott
Summary: Lipidic nanoparticles, especially liposomes, have been proven to be successful and versatile for intracellular drug delivery. Recently, liposomes have shown promise in vaccination strategies and nucleic acid delivery in the COVID-19 pandemic. However, liposomes are not immunologically inert and may have limitations in certain conditions. This study investigated the physico-chemical characteristics of liposomes and their effects on basophil-like cells, revealing the association between liposome characteristics and cell activation and inflammatory responses.
Article
Immunology
Boyang Xu, Yuqi Kang, Yujing Du, Weiyi Guo, Li Zhu, Hong Zhang
Summary: This study explores the genetic mechanism underlying aHUS and the impact of CFHR1 isoforms on complement activation and sterile inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Materials Science, Ceramics
Xu Xinyuan, Xin Chen, Liu Gaopeng, Wang Bin, Ji Mengxia, Li Lina, Shan Ningjie, Yan Xingwang, Xia Jiexiang, Li Huaming
Summary: Developing photocatalysts with broad spectral response and high photogenerated carriers' separation efficiency has received significant attention in recent years. In this work, Pt nanoparticles (NPs) loaded Bi12O17Cl2 nanosheets composites (Pt/Bi12O17Cl2) were synthesized by a facile photoreduction method. The Pt NPs can serve as electron capture trap, accelerating charge transfer and boosting molecular oxygen activation, enhancing the photodegradation performance of rhodamine B (RhB) and ciprofloxacin (CIP).
CERAMICS INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Christine Vauthier
JOURNAL OF DRUG TARGETING
(2019)
Article
Microbiology
Wendell Wons Neves, Rejane Pereira Neves, Danielle Patricia Cerqueira Macedo, Giovanna Rodrigues de Araujo Eleamen, Elisangela Afonso de Moura Kretzschmar, Elquio Eleamen Oliveira, Francisco Jaime Bezerra Mendonca-Junior, Reginaldo Goncalves de Lima-Neto
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Christelle Zandanel, Magali Noiray, Christine Vauthier
PHARMACEUTICAL RESEARCH
(2020)
Review
Pharmacology & Pharmacy
Silvana Cartaxo da Costa Urtiga, Henrique Rodrigues Marcelino, Eryvaldo Socrates Tabosa do Egito, Elquio Eleamen Oliveira
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Chemistry, Multidisciplinary
Elquio Eleamen Oliveira, Maryeme Barendji, Christine Vauthier
PHARMACEUTICAL RESEARCH
(2020)
Article
Biotechnology & Applied Microbiology
I. Motta Felicio, R. Limongi de Souza, C. de Oliveira Melo, K. Y. Gervazio Lima, U. Vasconcelos, R. Olimpio de Moura, E. Eleamen Oliveira
Summary: A carvacrol nanoemulsion with good stability and improved antimicrobial activity against food pathogens compared to free oil was developed in this study, indicating its potential for incorporation into food formulations for microbial growth prevention and control.
LETTERS IN APPLIED MICROBIOLOGY
(2021)
Article
Chemistry, Applied
Silvana Cartaxo da Costa Urtiga, Vitoria Maria Oliveira Alves, Camila de Oliveira Melo, Marini Nascimento de Lima, Ernane Souza, Arcelina Pacheco Cunha, Nagila Maria Pontes Silva Ricardo, Elquio Eleamen Oliveira, Eryvaldo Socrates Tabosa do Egito
CARBOHYDRATE POLYMERS
(2020)
Article
Pharmacology & Pharmacy
F. Varenne, L. Devoille, A. Makky, N. Feltin, F. Violleau, G. Barratt, C. Vauthier
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2020)
Article
Chemistry, Physical
Camila de Oliveira Melo, Maria Salete da Silva Rodrigues, Marcus Vinicius Santos da Silva, Henrique Rodrigues Marcelino, Marcelo Montenegro Rabello, Ricardo Olimpio de Moura, Elquio Eleamen Oliveira
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Biochemistry & Molecular Biology
Amanda Gabrielle Barros Dantas, Rafael Limongi de Souza, Anderson Rodrigues de Almeida, Francisco Humberto Xavier Junior, Maira Galdino da Rocha Pitta, Moacyr Jesus Barreto de Melo Rego, Elquio Eleamen Oliveira
Summary: The study developed a stable carvacrol-loaded nanoemulsion (CVNE) that improved the immunomodulatory activity of carvacrol in peripheral blood mononuclear cells (PBMCs).
Review
Pharmacology & Pharmacy
Rafael Limongi de Souza, Amanda Gabrielle Barros Dantas, Camila de Oliveira Melo, Isabela Motta Felicio, Elquio Eleamen Oliveira
Summary: This review summarizes the development of carvacrol nano-based drug delivery systems in the food and pharmaceutical industries. Various methods of incorporating carvacrol into nanoemulsions, microemulsions, nanoparticles, solid lipid nanoparticles, and liposomes are discussed. Future perspectives for utilizing carvacrol nanobased drug delivery systems are also presented.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Rafael L. de Souza, Ana C. Mengarda, Daniel B. Roquini, Camila O. Melo, Mayara C. de Morais, Maria Cristina Espirito-Santo, Damiao P. de Sousa, Josue de Moraes, Elquio E. Oliveira
Summary: A carvacryl acetate nanoemulsion (CANE) was formulated and tested for its antischistosomal activity. In vitro experiments demonstrated that CANE had anthelmintic activity against Schistosoma mansoni adult worms and did not have cytotoxic effects on human and animal cell lines. In vivo studies showed that CANE was more effective than free compounds in reducing worm burden and egg production, especially for prepatent infections. Overall, CANE holds promise as a delivery system for schistosomiasis treatment.
Article
Chemistry, Medicinal
Rafael Limongi de Souza, Camila de Oliveira Melo, Luiza Carolina Franca Opretzka, Eduardo Lima Wandega, Cristiane Flora Villarreal, Elquio Eleamen Oliveira
Summary: A carvacrol-loaded nanoemulsion was developed and shown to have improved anti-inflammatory activity. The nanoemulsion had good pharmacological properties and exhibited no toxicity.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Pharmacology & Pharmacy
Henrique Rodrigues Marcelino, Brennda Martins Gabinio, Marine Nascimento de Lima, Silvana Cartaxo da Costa Urtiga, Gabriel Barros Rodrigues, Bruna Braga Dantas, Demetrius Antonio Machado de Araujo, Christina Alves Peixoto, Elquio Eleamen Oliveira
Summary: This study aimed to characterize the physicochemical properties and evaluate the in vitro cytotoxicity of diethylcarbamazine-loaded poly(caprolactone) nanoparticles. The nanoparticles exhibited desirable particle size distribution, zeta potential, and drug release behavior, and showed good biocompatibility in vitro.
BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)