Article
Pharmacology & Pharmacy
Onyinye Uwaezuoke, Lisa C. Du Toit, Pradeep Kumar, Naseer Ally, Yahya E. Choonara
Summary: This study investigated the potential use of transferosomes for delivering cyclosporine A to the eye. Linoleic acid was found to improve the stability and size of the transferosomes. Tween(R)-based formulation was preferred due to its lower toxicity profile. The prepared transferosomes showed significant drug release and adequate corneal permeability, remaining stable for four months at low temperature.
Article
Pharmacology & Pharmacy
Shery Jacob, Anroop B. Nair, Jigar Shah, Sumeet Gupta, Sai H. S. Boddu, Nagaraja Sreeharsha, Alex Joseph, Pottathil Shinu, Mohamed A. Morsy
Summary: Targeted drug delivery to ocular tissues is a challenging task due to their complicated anatomical and physical properties. Biocompatible and biodegradable lipid nanoparticles have emerged as a potential solution to overcome ocular barriers and improve the therapeutic efficacy. Lipid-based nanocarrier systems offer advantages such as increased bioavailability, sustained drug release, and decreased dosing frequency. Additionally, these formulations can be administered as patient-friendly droppable preparations without causing discomfort.
Article
Polymer Science
Abdul Shakur Khan, Kifayat Ullah Shah, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Maitham A. Al Hawaj, Yousef N. Alhashem, Shakira Ghazanfar, Kamran Ahmad Khan, Zahid Rasul Niazi, Arshad Farid
Summary: The study fabricated tacrolimus-loaded solid lipid nanoparticles (SLNs) converted into a gel for improved topical applications. The SLNs had small particle size and stable distribution, while the gel form showed better drug permeation and retention properties.
Review
Pharmacology & Pharmacy
Priyanka Agarwal, Ilva D. Rupenthal Buchanan
Summary: Topical eyedrop application is the preferred route for drug delivery to anterior segment tissues. However, the use of aqueous vehicles with additives and preservatives elevates their toxicity potential. Non-aqueous vehicles have been suggested as efficient alternatives, but they remain poorly researched and few formulations are available. This review challenges the conventional hypothesis and establishes a rationale for using non-aqueous vehicles for ocular drug delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Sahim Aziz Hazari, Harsimran Kaur, Ritu Karwasra, Mohammed A. S. Abourehab, Asim Ali Khan, Prashant Kesharwani
Summary: Psoriasis is a recurrent, inflammatory skin disease, affecting 2-5% of the global population. Traditional treatments have limitations and can cause harmful side effects. Novel drug delivery systems, such as lipid-based nanoparticles, are being developed to provide safer and more effective treatment options.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Pharmacology & Pharmacy
Nakamwi Akombaetwa, Ange B. B. Ilangala, Lorraine Thom, Patrick B. B. Memvanga, Bwalya Angel Witika, Aristote B. B. Buya
Summary: Skin delivery is a promising approach for effective drug delivery, but low skin permeability is a major challenge. Advances in skin delivery depend on overcoming the challenges associated with drug molecule permeation and skin irritation. Lipid nanosystems offer potential solutions, but their formulation requires careful consideration of factors such as particle size and surface charge.
Article
Pharmacology & Pharmacy
Ghazala Begum, Thomas Leigh, David Stanley, Ann Logan, Richard James Blanch
Summary: By conducting this study, it was found that acid and alkaline ocular chemical injuries disrupt the corneal epithelial barrier function differently. Acidic injury reduces the penetration of hydrophilic fluorescein and hydrophobic dexamethasone and rhodamine B, while alkaline injury increases fluorescein penetration with minimal effect on dexamethasone and rhodamine B penetration.
Article
Biochemistry & Molecular Biology
Zhishu Bao, Ailing Yu, Hui Shi, Yuhan Hu, Bo Jin, Dan Lin, Mali Dai, Lei Lei, Xingyi Li, Yuqin Wang
Summary: In this study, a glycol chitosan/oxidized hyaluronic acid hydrogel film for dual ophthalmic drug delivery was fabricated successfully. The hydrogel films exhibited a stepwise release of levofloxacin and dexamethasone, demonstrating potent antibacterial and anti-inflammatory activities.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Simise S. Sikhondze, Pedzisai A. Makoni, Roderick B. Walker, Sandile M. M. Khamanga
Summary: In this study, a once-daily-dosed chitosan-coated metronidazole (MTZ)-loaded solid lipid nanoparticles (SLNs) for ocular delivery were developed to improve the residence time and release of the drug in the eye, which may reduce patient non-adherence.
Article
Ophthalmology
Yingjia Yang, Alastair Lockwood
Summary: The eye is a complex organ with multiple barriers that restrict drug delivery, leading to low bioavailability of commercially available ophthalmic drugs. This paper reviews the mechanisms that impede drug delivery on the ocular surface and discusses methods and novel technologies to improve bioavailability.
EXPERIMENTAL EYE RESEARCH
(2022)
Article
Veterinary Sciences
Mizuki Kita, Kazutaka Kanai, Hiroki Mitsuhashi, Tomoki Noguchi, Noriaki Nagai, Mizuki Yamaguchi, Yuya Otaka, Rina Kudo, Yohei Yamashita, Kazuki Tajima
Summary: The study demonstrated that magnesium hydroxide nanoparticles (nMH) can improve the ocular hypotensive effect of timolol maleate (TM) without enhancing its side effects. The fixed combination of nMH-TM may be more effective for lowering intraocular pressure in dogs compared to TM alone.
VETERINARY SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Anroop B. Nair, Jigar Shah, Bandar E. Al-Dhubiab, Shery Jacob, Snehal S. Patel, Katharigatta N. Venugopala, Mohamed A. Morsy, Sumeet Gupta, Mahesh Attimarad, Nagaraja Sreeharsha, Pottathil Shinu
Summary: The study demonstrated that optimized solid lipid nanoparticles (SLNs) loaded with clarithromycin can improve ocular drug permeation and enhance the therapeutic potential of the drug, providing a promising drug delivery approach for treating endophthalmitis.
Article
Multidisciplinary Sciences
Beatriz Silva, Lidia M. Goncalves, Berta Sao Braz, Esmeralda Delgado
Summary: This study explored the possibility of delivering EPO beta to the posterior segment of the eye using a chitosan-hyaluronic acid nanoparticulate system via topical instillation. The results showed that topical administration of CS/HA nanoparticles did not cause adverse ocular effects and had no significant impact on microhematocrits or electroretinography. Immunofluorescence staining demonstrated the presence of EPO beta in the retina for up to 21 days after administration. In conclusion, topical administration of CS/HA nanoparticles could efficiently deliver EPO beta to the retina and has the potential for retinal neuroprotection.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Liangbo Chen, Feng Wu, Yan Pang, Dan Yan, Siyi Zhang, Fangjie Chen, Nianxuan Wu, Danni Gong, Jinyao Liu, Yao Fu, Xianqun Fan
Summary: The study demonstrates the formation of a durable and protective therapeutic nanocoating on the ocular surface by instilling biomimetic drug-loaded nanoparticles, which can specifically bind to ocular epithelium fibronectin and improve the stability of tear film. This approach shows therapeutic benefits in mouse and rabbit models of dry eye disease, indicating the potential of therapeutic nanocoating to treat eye diseases.
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Article
Biochemistry & Molecular Biology
Laura Soriano-Romani, Laura Contreras-Ruiz, Antonio Lopez-Garcia, Yolanda Diebold, Sharmila Masli
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Pharmacology & Pharmacy
Bisera Jurisic Dukovski, Marina Juretic, Danka Bracko, Danijela Randjelovic, Snezana Savic, Mario Crespo Moral, Yolanda Diebold, Jelena Filipovic-Grcic, Ivan Pepic, Jasmina Lovric
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2020)
Article
Multidisciplinary Sciences
Mario Crespo-Moral, Laura Garcia-Posadas, Antonio Lopez-Garcia, Yolanda Diebold
Review
Biochemistry & Molecular Biology
Luna Krstic, Maria J. Gonzalez-Garcia, Yolanda Diebold
Summary: This article discusses different drug delivery strategies employed for polyphenolic compounds in treating ocular pathologies related to oxidative stress and inflammation.
Review
Pharmacology & Pharmacy
Laura Garcia-Posadas, Yolanda Diebold
Review
Pharmacology & Pharmacy
Yolanda Diebold, Laura Garcia-Posadas
Summary: The conjunctiva, as a complex ocular tissue, plays a crucial role in protecting the ocular surface, but faces challenges in treatment. Cell therapy and tissue engineering techniques show promise in providing better treatment options for conjunctival diseases.
Review
Allergy
Neera Singh, Yolanda Diebold, Srikant K. Sahu, Andrea Leonardi
Summary: Epithelial barrier dysfunction plays a significant role in the development of ocular allergies, leading to chronic inflammation. Abnormal expression of tight junction proteins is reported in ocular allergies, but data is limited in chronic atopic keratoconjunctivitis and vernal keratoconjunctivitis.
Article
Ophthalmology
Laura Garcia-Posadas, Miguel J. Maldonado, Yolanda Diebold
Summary: Samples obtained from corneal surface ablation procedures can be used for in vitro studies, as cells showed high viability and remained viable for up to 14 days in culture. Protein expression analysis confirmed the presence of cytokeratin-3, ZO-1, Ki67, and E-cadherin, while gene expression studies showed successful isolation of RNA and detection of GAPDH expression.
EXPERIMENTAL EYE RESEARCH
(2022)
Editorial Material
Pharmacology & Pharmacy
Yolanda Diebold, Laura Garcia-Posadas
Article
Food Science & Technology
Maha M. Abdallah, Ines C. Leonardo, Luna Krstic, Amalia Enriquez-de-Salamanca, Yolanda Diebold, Maria J. Gonzalez-Garcia, Frederic B. Gaspar, Ana A. Matias, Maria Rosario Bronze, Naiara Fernandez
Summary: A green technique was developed to extract hyaluronic acid (HA) from tuna vitreous humor (TVH) for potential use in managing dry eye disease. The extracted HA displayed antioxidant effects and showed potential as a compound in dry eye disease management. The technique also produced deep eutectic solvents (DES) that exhibited efficient antimicrobial properties.
Article
Pharmacology & Pharmacy
Luna Krstic, Pekka Jarho, Marika Ruponen, Arto Urtti, Maria J. Gonzalez-Garcia, Yolanda Diebold
Summary: This study compared the effects of complexes with cyclodextrins and tertiary complexes with the addition of hyaluronic acid on the solubility and stability of quercetin and resveratrol. The results showed that both complexes improved the solubility and stability of the drugs, and had no cytotoxic effects. These findings indicate the potential use of these complexes as topical treatment for dry eye disease.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Ophthalmology
Laura Garcia-Posadas, Ismael Romero-Castillo, Nikolaos Katsinas, Antonio Lopez-Garcia, Yolanda Diebold
Summary: In this study, a new protocol was developed to culture IM-HConEpiC cells without collagen-coated surfaces, and the cells were found to maintain a conjunctival epithelial phenotype. The study also demonstrated that the cells responded appropriately to oxidative stress and inflammatory stimuli, indicating that they can be a valuable tool for functional studies of the conjunctiva.
EXPERIMENTAL EYE RESEARCH
(2022)
Review
Cell & Tissue Engineering
Maria Luz Alonso-Alonso, Laura Garcia-Posadas, Yolanda Diebold
Summary: Interest in AT-MSC-EVs for therapeutic potential has grown, with numerous proteins and miRNAs identified within, primarily involved in binding function and participating in processes like signal transduction and gene silencing. The therapeutic effects of AT-MSC-EVs are highlighted in biological processes such as inflammation, angiogenesis, and apoptosis.
STEM CELL REVIEWS AND REPORTS
(2022)
Meeting Abstract
Ophthalmology
Yolanda Diebold, Laura Garcia-Posadas, Antonio Lopez-Garcia, Mario Crespo-Moral
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Ivan Fernandez-Bueno, Maria-Luz Alonso-Alonso, Maria-Teresa Garcia-Gutierrez, Yolanda Diebold
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)