Article
Chemistry, Multidisciplinary
Miao Zhao, Edward Leggett, Struan Bourke, Souzana Poursanidou, Sadie Carter-Searjeant, Steve Po, Marciano Palma do Carmo, Lea Ann Dailey, Philip Manning, Sean G. Ryan, Laura Urbano, Mark A. Green, Aliaksandra Rakovich
Summary: Conjugated polymer nanoparticles (CPNs) based on PTB7 were prepared and evaluated for their potential in theranostic applications involving bioimaging and photosensitization. The CPNs showed efficient NIR-I transparency for bioimaging and demonstrated photosensitizing capabilities in both aqueous solutions and cell cultures. The photosensitizing ability of CPNs was found to be influenced by the stabilizing shell material, with Pluronic F-127 leading to enhanced ROS production and poly[styrene-co-maleic anhydride] completely quenching the process.
Article
Nanoscience & Nanotechnology
Lu Yang, Ruipeng Shi, Ruoxi Zhao, Yanlin Zhu, Bin Liu, Shili Gai, Lili Feng
Summary: This study constructed pH/near-infrared dual-responsive nanotheranostics for cancer treatment using ultrasmall tin dioxide (SnO2) and upconversion nanoparticles (UCNPs). The nanocapsules exhibited improved drug delivery efficiency, inherent imaging performance, and high treatment efficiency through combining photodynamic therapy, hyperthermia effect, and chemotherapy. Additionally, the tin element in the nanocapsules served as a contrast agent for CT imaging. This study demonstrated the potential of nanocapsules for cancer treatment with excellent biocompatibility.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Nanoscience & Nanotechnology
Netra Hiremath, Rahul Kumar, Kuo Chu Hwang, Indranil Banerjee, Suresh Thangudu, Raviraj Vankayala
Summary: 2D nanomaterials with high surface area and unique optical properties have great potential in phototherapeutic and diagnostic applications. They can load different molecules for phototherapy and enhance optical absorption and biocompatibility by adding other nanoparticles or molecules.
ACS APPLIED NANO MATERIALS
(2022)
Article
Medicine, Research & Experimental
Guodong Ren, ZiCheng Wang, Yafei Tian, Jinyao Li, Yingyu Ma, Liang Zhou, Chengwu Zhang, Lixia Guo, Haipeng Diao, Lihong Li, Li Lu, Sufang Ma, Zhifang Wu, Lili Yan, Wen Liu
Summary: Esophageal cancer, as the sixth leading cause of cancer death globally, poses a significant threat to human life. The traditional treatments for this type of cancer face numerous challenges, including invasion, multidrug resistance, and off-target toxicity. Chemo & Photodynamic synergistic therapy has emerged as a promising approach for more effective treatment. However, its success is hindered by the lack of tumor targeting, deleterious side effects, and unfavorable microenvironment for photodynamic therapy. To overcome these obstacles, a theranostic nano-assembly drug, GCDs-Ce6/Pt-EGF, was developed. It demonstrated enhanced tumor cell killing capacity and improved biosafety, especially for EGFR bearing tumors, paving the way for the development of novel theranostic agents for potential clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Materials Science, Biomaterials
Libiao Yan, Siqi Lin, Lina Wang, Yupeng Wang, Dongfang Zhou, Qingbing Zeng
Summary: Photodynamic therapy (PDT) in cancer therapy has shown promising results, but it is limited by the penetration depth of light, insufficient O-2 supply in the hypoxic microenvironment, and high levels of reducing substances in cancer cells. To overcome these limitations, a multifunctional MnO2 nanoparticle loaded with the photosensitizer Ce6 and modified with polydopamine was developed, providing efficient PDT/mild PTT combination therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Pranjyan Dash, Senthilkumar Thirumurugan, Ching-Li Tseng, Yu-Chien Lin, Sung-Lung Chen, Udesh Dhawan, Ren-Jei Chung
Summary: This study developed dumbbell-shaped nanocomposites consisting of titanium dioxide/gold nanorods coated with mesoporous silica shells. Methotrexate was loaded onto the nanocomposites and upconversion nanoparticles were decorated to enhance the therapeutic effects. In vitro and in vivo experiments demonstrated the synergistic photodynamic therapy, photothermal therapy, and chemotherapy effects of the nanocomposites, making them a promising candidate for cancer treatment using near-infrared light.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Endocrinology & Metabolism
Leela R. Jaidev, Laxmi S. Chede, Hemanth K. Kandikattu
Summary: Pancreatic cancer is a low vascular permeable tumor with a high mortality rate. Drug delivery field is developing unique carriers for high mortality rate cancers like pancreatic cancer, such as theranostic nanoparticles which carry both diagnostic and therapeutic agents. This review discusses various therapeutic and theranostic nanocarriers for pancreatic cancer.
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2021)
Review
Nanoscience & Nanotechnology
Sumera Khizar, Nasir M. Ahmad, Nadia Zine, Nicole Jaffrezic-Renault, Abdelhamid Errachid-el-salhi, Abdelhamid Elaissari
Summary: In the past few years, engineered inorganic nanoparticles have been increasingly studied and applied in the biomedical field for their potential in combining diagnosis and treatment through various approaches such as imaging, targeting, and therapy. Magnetic nanoparticles have gained attention in materials science due to their unique capabilities in targeting, imaging, therapy, and controlled drug release, among others. Decorating or functionalizing magnetic nanoparticles with different materials can enhance their biocompatibility, stability, and therapeutic efficacy.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jisue Kim, Chulhwan Park, Younghun Kim
Summary: The photothermal effect generated by the local surface plasmon phenomenon of metal nanoparticles can be harnessed to develop multifunctional nano-pigments with high heat energy conversion efficiency and bright colors. This study synthesized a grayish blue nano-pigment with a high photothermal effect in the near-infrared region and demonstrated its applicability in paints.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Huilin Xie, Zhenyu Bi, Junli Yin, Zeshun Li, Lianrui Hu, Chen Zhang, Jianquan Zhang, Jacky W. Y. Lam, Pengfei Zhang, Ryan T. K. Kwok, Kai Li, Ben Zhong Tang
Summary: Fluorescence-guided phototherapy is an emerging noninvasive cancer treatment strategy. Organic molecules, with their easy construction, simple modification, and good biocompatibility, have shown promise as theranostic agents. This study successfully developed a versatile theranostic platform based on an aggregation-induced emission luminogen, TPA-TBT, which exhibited near-infrared emission, high fluorescence quantum yield, robust reactive oxygen species production, and excellent photothermal conversion efficiency. In vivo studies demonstrated its outstanding efficacy in both photodynamic and photothermal therapies against tumors in a mouse model. This work provides a design strategy for developing all-in-one cancer theranostic agents by modulating and utilizing the relaxation energy of excitons.
Article
Chemistry, Analytical
Yu-Bin Su, Xu Zhao, Li-Jian Chen, Hai-Long Qian, Xiu-Ping Yan
Summary: The development of a novel theranostic nanoprobe for imaging-guided PDT is reported in this study. The nanoprobe integrates PLNP for autofluorescence-free bioimaging, TCPP for PDT, and AS1411 aptamer-contained DNA for specific binding to cancer cells. This work provides a new imaging-guided PDT nanoplatform for theranostics.
Article
Medicine, Research & Experimental
Fuyuki F. Inagaki, Hiroaki Wakiyama, Aki Furusawa, Ryuhei Okada, Takuya Kato, Daiki Fujimura, Shuhei Okuyama, Hiroshi Fukushima, Seiichiro Takao, Peter L. Choyke, Hisataka Kobayashi
Summary: Bones are a common site for metastasis from solid tumors, and current treatments are not curative. Near-infrared photoimmunotherapy (NIR-PIT), which uses antibodies labeled with IRDye700DX (IR700) activated by NIR light, has shown success in treating head and neck cancer but has not been tested on bone metastases. This study investigated the efficacy of EGFR-targeted NIR-PIT on bone metastatic lesions using a mouse model and found that it had a therapeutic effect and could repair metastasis-induced bone destruction.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Immunology
Chuan Zhang, Yujuan Zhang, Maolin Liang, Xiumin Shi, Yan Jun, Longfei Fan, Kai Yang, Feng Wang, Wei Li, Ran Zhu
Summary: This study presents a designed nanoprobe and nanonuclear drug for targeted therapy and prediction of lymph node metastasis in breast cancer. The nanoprobe effectively targets and accumulates in lymphatic metastasis, while the nanonuclear drug reduces the incidence and volume of lymph node metastasis. The nanoprobe and nanonuclear drug exhibit excellent stability and minimal toxicity. These findings provide potential alternatives for the diagnosis and treatment of lymph node metastasis.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Environmental Sciences
Xiaofeng Li
Summary: Although chemotherapy drugs are widely used in cancer treatment, their administration has faced problems such as chemoresistance and concentration-related toxicity. Doxorubicin (DOX) is an effective drug for tumor treatment, but it can also cause side effects and cardiac toxicity. The paper discusses the mechanism of DOX-mediated toxicity and explores the use of drugs and nanotherapeutics to alleviate cardiovascular diseases caused by DOX.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Huazhong Cai, Yanxia Chen, Liusheng Xu, Yingping Zou, Xiaoliang Zhou, Guoxin Liang, Dongqing Wang, Zhimin Tao
Summary: In this study, chemically synthetic polymer PBDFDTBO was coated with amphiphilic polymers PEO-PCL and DSPE-PEG to form stable fluorescent nanoparticles. Physicochemical properties of the nanoparticles were characterized, and in vitro and in vivo studies showed that the hydrophobic composition of the nanoparticles affected their biodistribution and tumor accumulation. Different coating strategies can impact the performance of nanoparticles in pancreatic cancer delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Xinzhe Yu, Yang Di, Chao Xie, Yunlong Song, Hang He, Hengchao Li, Xinming Pu, Weiyue Lu, Deliang Fu, Chen Jin
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Article
Engineering, Biomedical
Xinzhe Yu, Chen Jin
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2016)
Review
Surgery
Xinzhe Yu, Hengchao Li, Chen Jin, Deliang Fu, Yang Di, Sijie Hao, Ji Li
LANGENBECKS ARCHIVES OF SURGERY
(2015)
Article
Oncology
Xinzhe Yu, Hengchao Li, Deliang Fu, Chen Jin, Ji Li
Review
Oncology
Xinzhe Yu, Feng Yang, De-liang Fu, Chen Jin
EXPERT REVIEW OF ANTICANCER THERAPY
(2016)
Article
Biochemistry & Molecular Biology
Xinzhe Yu, Lie Yao, Yang Di, Hang He, Xiaoxia Li, Chun Zhang, Deliang Fu, Chen Jin, Ji Li
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2016)
Review
Surgery
Feng Yang, Xinzhe Yu, Yun Bao, Zunguo Du, Chen Jin, Deliang Fu
Article
Gastroenterology & Hepatology
Xin-Zhe Yu, Zhong-Yi Guo, Yang Di, Feng Yang, Qi Ouyang, De-Liang Fu, Chen Jin
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2017)
Review
Surgery
Xinzhe Yu, Jichun Gu, Deliang Fu, Chen Jin
INTERNATIONAL JOURNAL OF SURGERY
(2017)
Review
Oncology
X. Z. Yu, J. Li, D. L. Fu, Y. Di, F. Yang, S. J. Hao, C. Jin
Article
Biochemistry & Molecular Biology
Dexiang Zhu, Jie Wang, Li Ren, Yan Li, Bin Xu, Ye Wei, Yunshi Zhong, Xinzhe Yu, Shenyong Zhai, Jianmin Xu, Xinyu Qin
JOURNAL OF CELLULAR BIOCHEMISTRY
(2013)
Article
Multidisciplinary Sciences
Xinzhe Yu, Yunlong Song, Yang Di, Hang He, Deliang Fu, Chen Jin
SCIENTIFIC REPORTS
(2016)
Review
Oncology
Xinzhe Yu, Jichun Gu, Haoxuan Wu, Deliang Fu, Ji Li, Chen Jin
JOURNAL OF ONCOLOGY
(2018)
