Article
Immunology
Joanna Matysiak, Eliza Matuszewska, Marek L. Kowalski, Slawomir W. Kosinski, Ewa Smorawska-Sabanty, Jan Matysiak
Summary: Venom immunotherapy (VIT) in allergic patients is closely associated with changes in serum proteomic patterns, particularly involving complement proteins and myosin, with major proteomic changes detected in high responder group, suggesting a direct response to VIT.
Article
Immunology
Zhi Zheng, Qingfeng Wei, Xianghui Wan, Xiaoming Zhong, Lijuan Liu, Jiquan Zeng, Lihua Mao, Xiaojian Han, Fangfang Tou, Jun Rao
Summary: In this study, integrated proteomics and metabolomics analyses were performed on serum samples from advanced CRC patients. Significant alterations in proteins and metabolites were found after treatment. The proteomics analysis identified changes in cancer-related pathways and immune response pathways, while the metabolomics analysis revealed changes in pathways associated with lipid metabolism. The results of this study not only expanded our understanding of the molecular basis of advanced CRC but also provided potential novel therapeutic targets for CRC treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Jia Yi, Yueqing Shen, Yi Yang, Chengpin Shen, Baohong Liu, Liang Qiao, Yan Wang
Summary: By characterizing gingival crevicular fluid (GCF) sediments and identifying potential protein biomarkers using mass spectrometry techniques, this study has contributed to the early diagnosis of periodontitis and understanding of its pathogenesis. The identified biomarkers hold potential value for accurate monitoring and can be utilized by non-specialists for widespread screening.
Review
Chemistry, Analytical
Negin Fasih Ramandi, Mohammad Faranoush, Alireza Ghassempour, Hassan Y. Aboul-Enein
Summary: The recent success in studying the proteome as a source of biomarkers has revolutionized our understanding of leukemia. The use of mass spectrometry techniques to identify differentially expressed proteins has led to improved diagnosis, prognosis, and treatment strategies for leukemia. This review focuses on the use of various ionization sources and mass analyzers in monitoring different types of leukemia, with MALDI-TOF MS identified as a quick and reliable method for protein analysis. Additionally, the review classifies over 400 proteins and identifies specific biomarkers for acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and other stages of leukemia for future studies.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Nazli Mert-Ozupek, Gizem Calibasi-Kocal, Nur Olgun, Yasemin Basbinar, Levent Cavas, Hulya Ellidokuz
Summary: The study compared caulerpin levels in invasive and non-invasive Caulerpa extracts for the first time, showing higher levels in the invasive species. Furthermore, caulerpin from invasive Caulerpa demonstrated anticancer activities by reducing cell viability, inhibiting invasion-migration, and inducing apoptosis in colorectal cancer cells.
Article
Chemistry, Organic
Bernard Fernandez, Jean Armengaud, Gilles Subra, Christine Enjalbal
Summary: This study investigates the feasibility of using high energy charge remote fragmentations to analyze the N-terminus of proteins, and compares it with low energy collision-induced dissociations. The results show that the amino acid composition significantly affects the dissociation pathways of peptide backbones.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jun Rao, Xianghui Wan, Fangfang Tou, Qinsi He, Aihua Xiong, Xinyi Chen, Wenhao Cui, Zhi Zheng
Summary: This study used proteomics and metabolomics techniques to analyze serum samples from patients with advanced CRC, identifying potential biomarkers and pathways associated with cancer cell metabolism. The results suggest the conservation role of lipids in the regulatory network of advanced CRC and discovered novel biomarkers that can improve diagnosis and monitoring of advanced CRC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Food Science & Technology
Xue Li, Xiaorong Deng, Xin Guo, Yabo Wei, Yunfeng Zhao, Xiaobing Guo, Xinrong Zhu, Jian Zhang, Ling Hu
Summary: The present study investigates the freshness indicator protein of Coregonus peled and the effects of oxidation on the quality of fish during 4 degrees C storage. A total of 382 differential proteins were identified, and 20 proteins related to oxidation were found to have the potential as biomarkers for protein oxidative damage. Actin was identified as an indicator for fish softening during postmortem storage. The changes in protein structure and biomarkers were influenced by oxidation. Bioinformatics analysis suggested that differentially expressed proteins participated in the metabolic pathway during 4 degrees C storage.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Xiaojing Sheng, Satoshi Nagaoka, Marika Hashimoto, Yusuke Amiya, Masato Beppu, Kenichiro Tsukamoto, Emiko Yanase, Mitsuru Tanaka, Toshiro Matsui
Summary: Beta-conglycinin was orally administered to rats, and specific oligopeptides derived from the protein were identified in the blood plasma, indicating that beta-conglycinin could be the dietary source protein for these peptides found in the circulating bloodstream of rats.
Article
Agriculture, Dairy & Animal Science
Prasad M. Govindaiah, Naveena B. Maheswarappa, Rituparna Banerjee, Bidyut Prava Mishra, Balaji B. Manohar, Sowmya Dasoju
Summary: This study evaluated the impact of different slaughter methods on meat quality and various biochemical and hormonal parameters. The results showed that electrical stunning had some effect on meat quality, while there were no significant differences in blood parameters between the non-stunning and stunning groups. Proteomic analysis identified differentially abundant proteins between the two groups.
Article
Biology
Marcelo de M. A. Coura, Eder A. Barbosa, Guilherme D. Brand, Carlos Bloch, Joao B. de Sousa
Summary: The incidence of colorectal cancer (CRC) is increasing in Brazil and there is a lack of reliable biomarkers for diagnosis and prognosis. Alterations in N-glycosylation profiles in serum and tissues of colon cancer patients were identified using mass spectrometry technologies. While serum N-glycans were mostly decreased, certain forms were overexpressed in tumor tissues. There was little correlation between tissue and serum N-glycosylation profiles in cancer patients. Total serum N-glycome analysis showed potential in discriminating patients from healthy controls, but compositions in serum did not parallel those found in tumor tissues.
Review
Microbiology
Eva Torres-Sangiao, Cristina Leal Rodriguez, Carlos Garcia-Riestra
Summary: Mass spectrometry (MS) has emerged as a powerful tool in clinical microbiology for rapid and reliable microbial identification. Its cost- and time-effective advantages make it a promising alternative to conventional methods, offering potential applications in early diagnosis and appropriate treatment of severe infections.
Article
Chemistry, Analytical
Liang Shan, Han Gao, Jing Zhang, Wentao Li, Yue Su, Yinlong Guo
Summary: This study combined MALDI-TOF MS with EM technology to directly analyze exosomal proteins in human plasma and serum. The results showed that EM had higher sensitivity in the high-mass range and characteristic exosomal proteins were identified. Furthermore, when using EM as a detector, there was a good linear relationship between peak intensity and concentration.
Article
Engineering, Biomedical
Xinyue Han, Dandan Li, Shurong Wang, Yuxiang Lin, Yun Liu, Ling Lin, Liang Qiao
Summary: In this study, a non-invasive liquid biopsy method was developed for the diagnosis of TNBC by quantifying free serum amino acids using colloidosomes-coupled MALDI-TOF MS. A machine learning-based classification model was built based on the quantities of serum free amino acids to differentiate TNBC patients from the controls. The method showed high sensitivity, specificity, and accuracy. With the advantages of low cost, low sample consumption, high throughput in analysis, and high accuracy in identification, this method is promising for clinical diagnosis of TNBC.
MATERIALS TODAY BIO
(2022)
Article
Food Science & Technology
Katrien Dierickx, Samantha Presslee, Virginia L. Harvey
Summary: This research presents an alternative proteomic technique for reliable species identification of fish specimens. The study demonstrates the efficacy of collagen peptide mass fingerprinting in identifying different tissue types of fish samples, highlighting its importance in detecting mislabelling fraud in the food chain.
Article
Nanoscience & Nanotechnology
Xinzhe Yu, Yang Di, Chao Xie, Yunlong Song, Hang He, Hengchao Li, Xinming Pu, Weiyue Lu, Deliang Fu, Chen Jin
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2015)
Article
Engineering, Biomedical
Xinzhe Yu, Chen Jin
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
(2016)
Review
Surgery
Xinzhe Yu, Hengchao Li, Chen Jin, Deliang Fu, Yang Di, Sijie Hao, Ji Li
LANGENBECKS ARCHIVES OF SURGERY
(2015)
Article
Oncology
Xinzhe Yu, Hengchao Li, Deliang Fu, Chen Jin, Ji Li
Review
Oncology
Xinzhe Yu, Feng Yang, De-liang Fu, Chen Jin
EXPERT REVIEW OF ANTICANCER THERAPY
(2016)
Article
Biochemistry & Molecular Biology
Xinzhe Yu, Lie Yao, Yang Di, Hang He, Xiaoxia Li, Chun Zhang, Deliang Fu, Chen Jin, Ji Li
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2016)
Review
Surgery
Feng Yang, Xinzhe Yu, Yun Bao, Zunguo Du, Chen Jin, Deliang Fu
Article
Gastroenterology & Hepatology
Xin-Zhe Yu, Zhong-Yi Guo, Yang Di, Feng Yang, Qi Ouyang, De-Liang Fu, Chen Jin
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2017)
Article
Nanoscience & Nanotechnology
Xinzhe Yu, Wenwen Zhu, Yang Di, Jichun Gu, Zhongyi Guo, Hengchao Li, Deliang Fu, Chen Jin
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2017)
Review
Surgery
Xinzhe Yu, Jichun Gu, Deliang Fu, Chen Jin
INTERNATIONAL JOURNAL OF SURGERY
(2017)
Review
Oncology
X. Z. Yu, J. Li, D. L. Fu, Y. Di, F. Yang, S. J. Hao, C. Jin
Article
Multidisciplinary Sciences
Xinzhe Yu, Yunlong Song, Yang Di, Hang He, Deliang Fu, Chen Jin
SCIENTIFIC REPORTS
(2016)
Review
Oncology
Xinzhe Yu, Jichun Gu, Haoxuan Wu, Deliang Fu, Ji Li, Chen Jin
JOURNAL OF ONCOLOGY
(2018)