High-Throughput Screening Methodology to Identify Alpha-Synuclein Aggregation Inhibitors

α-Synuclein aggregation, seeding and inhibition by scyllo-inositol

(2016) Tarek Ibrahim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stabilization of α-Synuclein Fibril Clusters Prevents Fragmentation and Reduces Seeding Activity and Toxicity

(2016) Huy T. Lam et al.   BIOCHEMISTRY

Understanding Caffeine’s Role in Attenuating the Toxicity of α-Synuclein Aggregates: Implications for Risk of Parkinson’s Disease

(2015) Jay Kardani et al.   ACS Chemical Neuroscience

Contact between the β1 and β2 Segments of α-Synuclein that Inhibits Amyloid Formation

(2015) Hamed Shaykhalishahi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to α-synuclein aggregates

(2015) Andreas A. Deeg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Fibril Breaking Accelerates α-Synuclein Fibrillization

(2015) Volodymyr V. Shvadchak et al.   JOURNAL OF PHYSICAL CHEMISTRY B

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

α-synuclein-lanthanide metal ions interaction: binding sites, conformation and fibrillation

(2015) Jia Bai et al.   BMC Biophysics

Unveiling transient protein-protein interactions that modulate inhibition of alpha-synuclein aggregation by beta-synuclein, a pre-synaptic protein that co-localizes with alpha-synuclein

(2015) Maria K. Janowska et al.   Scientific Reports

Structure based aggregation studies reveal the presence of helix-rich intermediate during α-Synuclein aggregation

(2015) Dhiman Ghosh et al.   Scientific Reports

Flavone Derivatives as Inhibitors of Insulin Amyloid-Like Fibril Formation

(2015) Ricardas Malisauskas et al.   PLoS One

Curcumin Pyrazole and its derivative (N-(3-Nitrophenylpyrazole) Curcumin inhibit aggregation, disrupt fibrils and modulate toxicity of Wild type and Mutant α-Synuclein

(2015) Nuzhat Ahsan et al.   Scientific Reports

The Role of Stable α-Synuclein Oligomers in the Molecular Events Underlying Amyloid Formation

(2014) Nikolai Lorenzen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dopamine-induced α-synuclein oligomers show self- and cross-propagation properties

(2014) Matthew S. Planchard et al.   PROTEIN SCIENCE

Modeling of chemical inhibition from amyloid protein aggregation kinetics

(2014) José Antonio Vázquez   BMC Pharmacology & Toxicology

In Vitro Study of α-Synuclein Protofibrils by Cryo-EM Suggests a Cu2+-Dependent Aggregation Pathway

(2013) Hangyu Zhang et al.   BIOPHYSICAL JOURNAL

The Function of α-Synuclein

(2013) Jacob T. Bendor et al.   NEURON

The genetics and neuropathology of Parkinson’s disease

(2012) Henry Houlden et al.   ACTA NEUROPATHOLOGICA

Toxic prefibrillar α-synuclein amyloid oligomers adopt a distinctive antiparallel β-sheet structure

(2012) María Soledad Celej et al.   BIOCHEMICAL JOURNAL

Protein aggregation: Mechanisms and functional consequences

(2012) Gaetano Invernizzi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Strategies to increase the reproducibility of protein fibrillization in plate reader assays

(2010) Lise Giehm et al.   ANALYTICAL BIOCHEMISTRY

Tanshinone IIA attenuates neuronal damage and the impairment of long-term potentiation induced by hydrogen peroxide

(2010) Wei Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Baicalein reduces E46K α-synuclein aggregation in vitro and protects cells against E46K α-synuclein toxicity in cell models of familiar Parkinsonism

(2010) Mali Jiang et al.   JOURNAL OF NEUROCHEMISTRY

In Vitro Formation of Amyloid from α-Synuclein Is Dominated by Reactions at Hydrophobic Interfaces

(2010) Jeremy Pronchik et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pre-fibrillar α-synuclein variants with impaired β-structure increase neurotoxicity in Parkinson's disease models

(2009) Damla Pinar Karpinar et al.   EMBO JOURNAL

Fitting Neurological Protein Aggregation Kinetic Data via a 2-Step, Minimal/“Ockham's Razor” Model:  The Finke−Watzky Mechanism of Nucleation Followed by Autocatalytic Surface Growth†

(2008) Aimee M. Morris et al.   BIOCHEMISTRY

Impact of Tyr to Ala mutations on α-synuclein fibrillation and structural properties

(2008) Nataša Poklar Ulrih et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE