Article
Biochemistry & Molecular Biology
Elena Lonati, Gessica Sala, Paolo Corbetta, Stefania Pagliari, Emanuela Cazzaniga, Laura Botto, Pierangela Rovellini, Ilaria Bruni, Paola Palestini, Alessandra Bulbarelli
Summary: Epigenetic changes, host-gut microbiota interactions, and environmental factors contribute to the onset and progression of inflammatory bowel disease (IBD). A healthy lifestyle can help slow down the chronic or remitting/relapsing intestinal inflammation seen in IBD. One potential strategy to prevent or supplement disease therapies is the consumption of functional foods, such as cinnamon extract, which has antioxidant and anti-inflammatory properties. In this study, the researchers investigated the effects of digested cinnamon extract on the intestinal barrier and found that it prevented loss of transepithelial electrical resistance (TEER) by regulating claudin-2 protein levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Madhuri Rudraraju, S. Priya Narayanan, Payaningal R. Somanath
Summary: High blood sugar and infection mediators have different effects on the blood-retinal barrier, which may lead to ocular diseases.
Article
Cell Biology
Zhenguo Yang, Panpan Lin, Bing Chen, Xiaoqi Zhang, Wei Xiao, Shuilong Wu, Chunnian Huang, Du Feng, Wenqing Zhang, Jingjing Zhang
Summary: In stroke patients, autophagy activation leads to abnormal aggregation of CLDN5 in BMECs, causing BBB breakdown. Meanwhile, autophagy also contributes to the degradation of CAV1 and aggregated CLDN5, alleviating BBB impairment.
Article
Physiology
Ping Yu, Yanyu Li, Gaoliang Zhong, Wen Li, Bing Chen, Jingjing Zhang
Summary: This study found that loss of membranous Claudin-5 led to hypoxia-induced autophagy in cerebrovascular endothelial cells, partially attenuating endothelial cell apoptosis. Mechanism studies showed that membranous Claudin-5 affected the stimulation of HIF-1a and iNOS under hypoxic conditions, leading to suppressed endothelial autophagy. Loss of Claudin-5 also influenced the generation of ROS and expression of Bnip3, contributing to the inhibition of endothelial autophagy under hypoxia.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Isadora Oliveira Carvalho, Cleo Vanessa Gomes Queiroz, Gabriela Fernandes Oliveira Marques, Raquel Magalhaes Castelo Branco Craveiro, Francisco Antonio Felix Xavier Junior, Florencio Sousa Gouveia Junior, Luiz Gonzaga de Franca Lopes, Edna Maria Camelo Chaves, Helena Serra Azul Monteiro, Ana Maria Sampaio Assreuy, Janaina Serra Azul Monteiro Evangelista
Summary: The metal coordination complex FOR811A exhibits anti-inflammatory and antioxidant effects in mouse models of inflammation, achieved through the nitric oxide pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Diqi Yang, Ruiling Yin, Qianghui Lei, Jiandi Zhu, Sha Nan, Ning Ma, Hongmei Zhu, Jianguo Chen, Li Han, Mingxing Ding, Yi Ding
Summary: Baicalin alleviates endometrial inflammatory injury by regulating autophagy and influencing the redistribution of TJ proteins, providing a new therapeutic approach for preventing embryo loss and endometritis.
Article
Multidisciplinary Sciences
Simeng Lin, Nicholas A. Kennedy, Aamir Saifuddin, Diana Munoz Sandoval, Catherine J. Reynolds, Rocio Castro Seoane, Sherine H. Kottoor, Franziska P. Pieper, Kai-Min Lin, David K. Butler, Neil Chanchlani, Rachel Nice, Desmond Chee, Claire Bewshea, Malik Janjua, Timothy J. McDonald, Shaji Sebastian, James L. Alexander, Laura Constable, James C. Lee, Charles D. Murray, Ailsa L. Hart, Peter M. Irving, Gareth-Rhys Jones, Klaartje B. Kok, Christopher A. Lamb, Charlie W. Lees, Daniel M. Altmann, Rosemary J. Boyton, James R. Goodhand, Nick Powell, Tariq Ahmad
Summary: This study reports immune responses and breakthrough infections in patients with inflammatory bowel disease receiving anti-TNF treatments after receiving COVID-19 vaccination, and suggests the need for adapted vaccination schedules for these patients.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Eldar Hochman, Michal Taler, Reut Flug, Shay Gur, Shira Dar, Gil Bormant, Dori Blattberg, Uri Nitzan, Amir Krivoy, Abraham Weizman
Summary: Accumulating evidence suggests that inflammation and NVU dysfunction disrupt BBB integrity and contribute to depression. The endothelial protein Claudin-5, which is involved in BBB integrity, has been implicated in psychiatric disorders including MDD and schizophrenia. In an animal model, the pro-inflammatory cytokine TNF-alpha was found to affect BBB permeability and claudin-5 expression. This study is the first to assess the relationship between serum levels of claudin-5 and TNF-alpha during MDEs. The results showed significantly higher levels of claudin-5 and TNF-alpha in MDE patients compared to healthy controls, suggesting a possible specific interaction between claudin-5 and TNF-alpha in depression pathogenesis.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Satoshi Endo, Tsubasa Nishiyama, Tomoe Matuoka, Takeshi Miura, Toru Nishinaka, Toshiyuki Matsunaga, Akira Ikari
Summary: The study showed that low concentrations of Lox can enhance intestinal barrier function by increasing the expression of CLDNs, with the metabolite Lox-RS playing an important role in improving efficacy on the barrier function.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, Research & Experimental
Harleen Kaur, Regis Moreau
Summary: The role of mTORC1 in the regulation of intestinal barrier function and permeability remains to be fully elucidated.
Article
Biochemistry & Molecular Biology
Olivier Escaffre, Peter Szaniszlo, Gabor Toro, Caitlyn L. L. Vilas, Brenna J. J. Servantes, Ernesto Lopez, Terry L. L. Juelich, Corri B. B. Levine, Susan L. F. McLellan, Jessica C. C. Cardenas, Alexander N. N. Freiberg, Katalin Modis
Summary: Recent studies have found that lung microvascular endothelial injury plays a crucial role in the development of COVID-19. This study explored the effects of H2S on the barrier function of lung endothelial cells and its potential therapeutic implications for COVID-19. The researchers observed that treatment with GYY4137, a slow-releasing H2S donor, reduced endothelial barrier permeability after exposure to plasma samples from COVID-19 patients or inactivated SARS-CoV-2 virus. These findings suggest that H2S-releasing compounds have the potential to ameliorate lung endothelial barrier disruption caused by SARS-CoV-2.
Review
Biochemistry & Molecular Biology
Tomoko Tashiro, Yu Sawada
Summary: Psoriasis is not only a skin disease but can also cause systemic inflammatory diseases. Clinical and experimental studies have shown that there is an important interaction between psoriasis and systemic inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Yingjie Zhao, Xuezhi Yang, Siyu Li, Bingjie Zhang, Susu Li, Xinwei Wang, Yueye Wang, Chengyan Jia, Yan Chang, Wei Wei
Summary: The modification of MSCs with sTNFRII-Fc shows promising therapeutic effects in treating rheumatoid arthritis by resisting apoptosis/autophagy induced by TNF-alpha and neutralizing TNF-alpha to block immune-inflammation cascade.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Aymun Madni Zubair, Muhammad Nasir Hayat Malik, Waqas Younis, Muhammad Atif Hayat Malik, Shah Jahan, Ishtiaq Ahmed, Alamgeer Yuchi, Muhammad Naveed Mushtaq, Romeeza Tahir, Muhammad Bilal Sarwar, Muhammad Roman, Ayaz Ali Khan, Muhammad Nouman Tahir, Muhammad Tariq Khan, Hafiz Amir Ali Kharl, Gagun Kamran, Abdullah Abdo Albegali, Ali Imran
Summary: This study explores the anti-arthritic effects of newly synthesized acetamide derivatives of 2-aminobenzimidazole (N1 and N2) in rats. The compounds showed dose-dependent anti-inflammatory activity and improved histopathological and hematological parameters in arthritic rats. The results suggest that N1 and N2 possess strong anti-arthritic activity by suppressing pro-inflammatory mediators.
INFLAMMOPHARMACOLOGY
(2022)
Article
Microbiology
Shanshan Li, Jidong Guo, Rongmei Liu, Fuzhen Zhang, Shu'an Wen, Yi Liu, Weicong Ren, Xuxia Zhang, Yuanyuan Shang, Mengqiu Gao, Jie Lu, Yu Pang
Summary: This study compared the gut microbiota composition and blood cytokine levels of tuberculous meningitis (TBM) patients, pulmonary tuberculosis patients, and healthy controls. The results showed significant gut microbiota dysbiosis in TBM patients, characterized by a high proportion of Escherichia-Shigella species, as well as increased levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) in the blood.
MICROBIOLOGY SPECTRUM
(2022)
Article
Oncology
Cong Zhang, Yujie Shen, Jiazheng Wang, Mingxia Zhou, Yingwei Chen
MOLECULAR MEDICINE REPORTS
(2018)
Review
Biotechnology & Applied Microbiology
Mingxia Zhou, Jing He, Yujie Shen, Cong Zhang, Jiazheng Wang, Yingwei Chen
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Medicine, General & Internal
Mingxia Zhou, Weimin Xu, Jiazheng Wang, Junkai Yan, Yingying Shi, Cong Zhang, Wensong Ge, Jin Wu, Peng Du, Yingwei Chen
Article
Integrative & Complementary Medicine
Zhihua Peng, Hong Zhan, Yijia Shao, Yan Xiong, Lijin Zeng, Cong Zhang, Zhihao Liu, Zhenhua Huang, Huanxing Su, Zhen Yang
Review
Immunology
Cong Zhang, Yan Xiong, Lijin Zeng, Zhihua Peng, Zhihao Liu, Hong Zhan, Zhen Yang
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Cong Zhang, Ying Liao, Zhihao Liu, Lijin Zeng, Zhihua Peng, Jinli Liao, Zhen Yang
FRONTIERS IN MOLECULAR BIOSCIENCES
(2020)
Article
Cardiac & Cardiovascular Systems
Lijin Zeng, Cong Zhang, Yuanting Zhu, Zhihao Liu, Gexiu Liu, Bin Zhang, Chang Tu, Zhen Yang
Summary: The study revealed that decreased EPC function in elderly male NSTEMI patients is associated with disease severity and may be connected with systemic inflammation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Yujie Shen, Min Zhou, Junkai Yan, Zizhen Gong, Yongtao Xiao, Cong Zhang, Peng Du, Yingwei Chen
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2017)