Sphingosine Kinase 1 and Sphingosine-1-Phosphate Signaling in Colorectal Cancer

SphK1 modulates cell migration and EMT-related marker expression by regulating the expression of p-FAK in colorectal cancer cells

(2017) Chun-Yan Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Regulatory miRNAs in Colorectal Carcinogenesis and Metastasis

(2017) Yongchen Guo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sphingosine kinase 1 expression enhances colon tumor growth

(2017) Hideki Furuya et al.   Journal of Translational Medicine

The JAK/STAT3 axis: A comprehensive drug target for solid malignancies

(2017) Jennifer Huynh et al.   SEMINARS IN CANCER BIOLOGY

MiR-124 acts as a tumor suppressor by inhibiting the expression of sphingosine kinase 1 and its downstream signaling in head and neck squamous cell carcinoma

(2017) Yuan Zhao et al.   Oncotarget

Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

(2017) Hojjat Bazzazi et al.   PLoS Computational Biology

Diagnostic and Therapeutic Potential of MicroRNAs in Lung Cancer

(2017) Kentaro Inamura   Cancers

Major Tumor Suppressor and Oncogenic Non-Coding RNAs: Clinical Relevance in Lung Cancer

(2017) Kentaro Inamura   Cells

Targeting colorectal cancer cells by a novel sphingosine kinase 1 inhibitor PF-543

(2016) TongFa Ju et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice

(2016) Meiyang Xi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting sphingosine kinase 1 induces MCL1-dependent cell death in acute myeloid leukemia

(2016) Jason A. Powell et al.   BLOOD

Serum miRNAs as predictive and preventive biomarker for pre-clinical hepatocellular carcinoma

(2016) Liang Li et al.   CANCER LETTERS

A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis

(2016) Bo Kyung A. Seong et al.   CANCER RESEARCH

Sphingosine kinase inhibitors: a review of patent literature (2006-2015)

(2016) Kevin R. Lynch et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Host sphingosine kinase 1 worsens pancreatic cancer peritoneal carcinomatosis

(2016) Hiroaki Aoki et al.   JOURNAL OF SURGICAL RESEARCH

Downregulated miR-506 expression facilitates pancreatic cancer progression and chemoresistance via SPHK1/Akt/NF-κB signaling

(2016) J Li et al.   ONCOGENE

MicroRNA-124 upregulation inhibits proliferation and invasion of osteosarcoma cells by targeting sphingosine kinase 1

(2016) Yan Zhou et al.   Human Cell

Tumor suppressor PRSS8 targets Sphk1/S1P/Stat3/Akt signaling in colorectal cancer

(2016) Yonghua Bao et al.   Oncotarget

GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer

(2016) Jing Yang et al.   Oncotarget

MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA

(2015) Zhanping Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MicroRNA-101 down-regulates sphingosine kinase 1 in colorectal cancer cells

(2015) Min-Bin Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Sphingosine Kinases Signalling in Carcinogenesis

(2015) Gabriella Marfe et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

SphK1 promotes tumor cell migration and invasion in colorectal cancer

(2015) Jianting Long et al.   TUMOR BIOLOGY

Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)

(2015) Zhanping Lu et al.   Oncotarget

TRAF2 regulates TNF and NF-κB signalling to suppress apoptosis and skin inflammation independently of Sphingosine kinase 1

(2015) Nima Etemadi et al.   eLife

Proteogenomic characterization of human colon and rectal cancer

(2014) Bing Zhang et al.   NATURE

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Circulating sphingosine-1-phosphate and erythrocyte sphingosine kinase-1 activity as novel biomarkers for early prostate cancer detection

(2012) J Nunes et al.   BRITISH JOURNAL OF CANCER

Sphingosine-1-Phosphate Links Persistent STAT3 Activation, Chronic Intestinal Inflammation, and Development of Colitis-Associated Cancer

(2012) Jie Liang et al.   CANCER CELL

Sphingosine kinase 1 promotes tumor progression and confers malignancy phenotypes of colon cancer by regulating the focal adhesion kinase pathway and adhesion molecules

(2012) SHI-QUAN LIU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The functional roles of S1P in immunity

(2012) Y. Hisano et al.   JOURNAL OF BIOCHEMISTRY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Sensitization of human colon cancer cells to sodium butyrate-induced apoptosis by modulation of sphingosine kinase 2 and protein kinase D

(2011) Min Xiao et al.   EXPERIMENTAL CELL RESEARCH

Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas

(2010) Jochen Gaedcke et al.   GENES CHROMOSOMES & CANCER

Inflammation and Cancer: IL-6 and STAT3 Complete the Link

(2009) Jacqueline Bromberg et al.   CANCER CELL

IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer

(2009) Sergei Grivennikov et al.   CANCER CELL

When the Sphingosine Kinase 1/Sphingosine 1-Phosphate Pathway Meets Hypoxia Signaling: New Targets for Cancer Therapy

(2009) I. Ader et al.   CANCER RESEARCH

Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway

(2009) Olga Sukocheva et al.   ENDOCRINOLOGY

Role for sphingosine kinase 1 in colon carcinogenesis

(2008) Toshihiko Kawamori et al.   FASEB JOURNAL

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS