Computational investigation of sphingosine kinase 1 (SphK1) and calcium dependent ERK1/2 activation downstream of VEGFR2 in endothelial cells

Ten years of anti-vascular endothelial growth factor therapy

(2016) Napoleone Ferrara et al.   NATURE REVIEWS DRUG DISCOVERY

Endothelial cells decode VEGF-mediated Ca2+signaling patterns to produce distinct functional responses

(2016) David P. Noren et al.   Science Signaling

Endothelial cells decode VEGF-mediated Ca2+signaling patterns to produce distinct functional responses

(2016) David P. Noren et al.   Science Signaling

Anti-S1P Antibody as a Novel Therapeutic Strategy for VEGFR TKI-Resistant Renal Cancer

(2015) L. Zhang et al.   CLINICAL CANCER RESEARCH

Site-Specific Phosphorylation of VEGFR2 Is Mediated by Receptor Trafficking: Insights from a Computational Model

(2015) Lindsay Wendel Clegg et al.   PLoS Computational Biology

Glycosylation-Dependent Lectin-Receptor Interactions Preserve Angiogenesis in Anti-VEGF Refractory Tumors

(2014) Diego O. Croci et al.   CELL

Targeting Receptor Tyrosine Kinases and Their Downstream Signaling with Cell-Penetrating Peptides in Human Pulmonary Artery Smooth Muscle and Endothelial Cells

(2014) Jun Yu et al.   Chemical Biology & Drug Design

Bevacizumab Combined With Chemotherapy for Platinum-Resistant Recurrent Ovarian Cancer: The AURELIA Open-Label Randomized Phase III Trial

(2014) Eric Pujade-Lauraine et al.   JOURNAL OF CLINICAL ONCOLOGY

Ramucirumab plus docetaxel versus placebo plus docetaxel for second-line treatment of stage IV non-small-cell lung cancer after disease progression on platinum-based therapy (REVEL): a multicentre, double-blind, randomised phase 3 trial

(2014) Edward B Garon et al.   LANCET

VEGFR2 trafficking: Speed doesn’t kill

(2013) Xi Zhang et al.   CELL CYCLE

Computational model of VEGFR2 pathway to ERK activation and modulation through receptor trafficking

(2013) Wan Hua Tan et al.   CELLULAR SIGNALLING

A systems biology view of blood vessel growth and remodelling

(2013) Elizabeth A. Logsdon et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ramucirumab monotherapy for previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (REGARD): an international, randomised, multicentre, placebo-controlled, phase 3 trial

(2013) Charles S Fuchs et al.   LANCET

Therapeutic angiogenesis for critical limb ischaemia

(2013) Brian H. Annex   Nature Reviews Cardiology

The Reactome pathway knowledgebase

(2013) David Croft et al.   NUCLEIC ACIDS RESEARCH

Signal Transduction by Vascular Endothelial Growth Factor Receptors

(2013) S. Koch et al.   Cold Spring Harbor Perspectives in Medicine

A Mathematical Model of T Lymphocyte Calcium Dynamics Derived from Single Transmembrane Protein Properties

(2013) Christine Schmeitz et al.   Frontiers in Immunology

Cediranib With mFOLFOX6 Versus Bevacizumab With mFOLFOX6 As First-Line Treatment for Patients With Advanced Colorectal Cancer: A Double-Blind, Randomized Phase III Study (HORIZON III)

(2012) Hans-Joachim Schmoll et al.   JOURNAL OF CLINICAL ONCOLOGY

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

(2012) Matthew W. Parker et al.   PLoS One

Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome

(2012) Marija Milacic et al.   Cancers

Signal transduction by vascular endothelial growth factor receptors

(2011) Sina Koch et al.   BIOCHEMICAL JOURNAL

Neuropilin-1 promotes VEGFR-2 trafficking through Rab11 vesicles thereby specifying signal output

(2011) K. Ballmer-Hofer et al.   BLOOD

Orai1 and CRAC Channel Dependence of VEGF-Activated Ca 2+ Entry and Endothelial Tube Formation

(2011) Jing Li et al.   CIRCULATION RESEARCH

HCC and angiogenesis: possible targets and future directions

(2011) Andrew X. Zhu et al.   Nature Reviews Clinical Oncology

Phosphorylation of Akt and ERK1/2 Is Required for VEGF-A/VEGFR2-Induced Proliferation and Migration of Lymphatic Endothelium

(2011) Michael T. Dellinger et al.   PLoS One

Vascular Endothelial Growth Factor Stimulates Endothelial Colony Forming Cells Proliferation and Tubulogenesis by Inducing Oscillations in Intracellular Ca2+ Concentration

(2011) Silvia Dragoni et al.   STEM CELLS

Overall survival with cisplatin-gemcitabine and bevacizumab or placebo as first-line therapy for nonsquamous non-small-cell lung cancer: results from a randomised phase III trial (AVAiL)

(2010) M. Reck et al.   ANNALS OF ONCOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Critical role of TRPC6 channels in VEGF-mediated angiogenesis

(2009) Ruiliang Ge et al.   CANCER LETTERS

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overall Survival and Updated Results for Sunitinib Compared With Interferon Alfa in Patients With Metastatic Renal Cell Carcinoma

(2009) Robert J. Motzer et al.   JOURNAL OF CLINICAL ONCOLOGY

Therapeutically Targeting ErbB3: A Key Node in Ligand-Induced Activation of the ErbB Receptor-PI3K Axis

(2009) B. Schoeberl et al.   Science Signaling

Ligand-Stimulated VEGFR2 Signaling is Regulated by Co-Ordinated Trafficking and Proteolysis

(2009) Alexander F. Bruns et al.   TRAFFIC

A compartment model of VEGF distribution in blood, healthy and diseased tissues

(2008) Marianne O Stefanini et al.   BMC Systems Biology

Bevacizumab Plus Interferon Alfa Compared With Interferon Alfa Monotherapy in Patients With Metastatic Renal Cell Carcinoma: CALGB 90206

(2008) Brian I. Rini et al.   JOURNAL OF CLINICAL ONCOLOGY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

VEGF-Mediated Elevated Intracellular Calcium and Angiogenesis in Human Microvascular Endothelial CellsIn Vitroare Inhibited by Dominant Negative TRPC6

(2008) M.A. Hamdollah Zadeh et al.   MICROCIRCULATION

New Role for the Protein Tyrosine Phosphatase DEP-1 in Akt Activation and Endothelial Cell Survival

(2008) C. Chabot et al.   MOLECULAR AND CELLULAR BIOLOGY

Ras oncogenes: split personalities

(2008) Antoine E. Karnoub et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Age-Related Macular Degeneration

(2008) Rama D. Jager et al.   NEW ENGLAND JOURNAL OF MEDICINE