Shp2 promotes metastasis of prostate cancer by attenuating the PAR3/PAR6/aPKC polarity protein complex and enhancing epithelial-to-mesenchymal transition

SHP2E76K mutant promotes lung tumorigenesis in transgenic mice

(2014) Valentina E. Schneeberger et al.   CARCINOGENESIS

TRIM59 Is Up-regulated in Gastric Tumors, Promoting Ubiquitination and Degradation of p53

(2014) Zhicheng Zhou et al.   GASTROENTEROLOGY

Contributions of epithelial-mesenchymal transition and cancer stem cells to the development of castration resistance of prostate cancer

(2014) Ping Li et al.   Molecular Cancer

Tyrosine phosphatase SHP2 increases cell motility in triple-negative breast cancer through the activation of SRC-family kinases

(2014) N Sausgruber et al.   ONCOGENE

Symmetrical and asymmetrical division analysis provides evidence for a hierarchy of prostate epithelial cell lineages

(2014) Jia Wang et al.   Nature Communications

The Tyrosine Phosphatase SHP2 Regulates Focal Adhesion Kinase to Promote EGF-Induced Lamellipodia Persistence and Cell Migration

(2013) Zachary R. Hartman et al.   MOLECULAR CANCER RESEARCH

The epigenetics of epithelial-mesenchymal plasticity in cancer

(2013) Wai Leong Tam et al.   NATURE MEDICINE

Prostate cancer progression after androgen deprivation therapy: mechanisms of castrate resistance and novel therapeutic approaches

(2013) T Karantanos et al.   ONCOGENE

Role of SHP2 phosphatase in KIT-induced transformation: identification of SHP2 as a druggable target in diseases involving oncogenic KIT

(2012) R. S. Mali et al.   BLOOD

Tumor Type-Dependent Function of the Par3 Polarity Protein in Skin Tumorigenesis

(2012) Sandra Iden et al.   CANCER CELL

Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis

(2012) Luke Martin McCaffrey et al.   CANCER CELL

The Signaling Adaptor Gab1 Regulates Cell Polarity by Acting as a PAR Protein Scaffold

(2012) Ziqiang Yang et al.   MOLECULAR CELL

The mutational landscape of lethal castration-resistant prostate cancer

(2012) Catherine S. Grasso et al.   NATURE

Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop

(2012) Nicola Aceto et al.   NATURE MEDICINE

A new model and modulator of pulmonary oedema

(2012) Charlotte Harrison   NATURE REVIEWS DRUG DISCOVERY

Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

(2011) H. H. Zhu et al.   BLOOD

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Tumor Metastasis: Molecular Insights and Evolving Paradigms

(2011) Scott Valastyan et al.   CELL

The dynamic interplay between a PTK (Kit) and a PTP (Shp2) in hematopoietic stem and progenitor cells

(2011) Helen He Zhu et al.   CELL CYCLE

SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver

(2011) Atsushi Takahashi et al.   MOLECULAR CELL

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

(2011) Y. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators

(2010) Ling Huang et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Molecular genetics of prostate cancer: new prospects for old challenges

(2010) M. M. Shen et al.   GENES & DEVELOPMENT

SHP2 Mediates the Localized Activation of Fyn Downstream of the  6 4 Integrin To Promote Carcinoma Invasion

(2010) X. Yang et al.   MOLECULAR AND CELLULAR BIOLOGY

Function, regulation and pathological roles of the Gab/DOS docking proteins

(2009) Franziska U Wöhrle et al.   Cell Communication and Signaling

Mechanisms of Asymmetric Stem Cell Division

(2008) Juergen A. Knoblich   CELL

Inhibition of SHP2 leads to mesenchymal to epithelial transition in breast cancer cells

(2008) X-D Zhou et al.   CELL DEATH AND DIFFERENTIATION

Polarity proteins in migration and invasion

(2008) S Etienne-Manneville   ONCOGENE