Impact of Natural Compounds on DNA Methylation Levels of the Tumor Suppressor Gene RASSF1A in Cancer

Guadecitabine (SGI-110) in treatment-naive patients with acute myeloid leukaemia: phase 2 results from a multicentre, randomised, phase 1/2 trial

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The tumor suppressor RASSF1A induces the YAP1 target gene ANKRD1 that is epigenetically inactivated in human cancers and inhibits tumor growth

(2017) Adriana P. Jiménez et al.   Oncotarget

An association between overexpression of DNA methyltransferase 3B4 and clear cell renal cell carcinoma

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Gene methylation as a powerful biomarker for detection and screening of non-small cell lung cancer in blood

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Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer

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Analysis of Liver Tumor-Prone Mouse Models of the Hippo Kinase Scaffold Proteins RASSF1A and SAV1

(2016) X. Zhang et al.   CANCER RESEARCH

Peperomin E reactivates silenced tumor suppressor genes in lung cancer cells by inhibition of DNA methyltransferase

(2016) Xin-zhi Wang et al.   CANCER SCIENCE

Emodin enhances the demethylation by 5-Aza-CdR of pancreatic cancer cell tumor-suppressor genes P16, RASSF1A and ppENK

(2016) FENG-PING PAN et al.   ONCOLOGY REPORTS

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

(2016) Sarandeep S.S. Boyanapalli et al.   PHARMACOLOGICAL RESEARCH

Clinical utility of RASSF1A methylation in human malignancies

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DNA Methyltransferases Inhibitors from Natural Sources

(2015) Clemens Zwergel et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Association of folate and other one-carbon related nutrients with hypermethylation status and expression of RARB, BRCA1, and RASSF1A genes in breast cancer patients

(2015) Saeed Pirouzpanah et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Gene promoter methylation and DNA repair capacity in monozygotic twins with discordant smoking habits

(2015) Laura Ottini et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Effects of emodin on the demethylation of tumor-suppressor genes in pancreatic cancer PANC-1 cells

(2015) HAO ZHANG et al.   ONCOLOGY REPORTS

Curcumin Reactivates Silenced Tumor Suppressor Gene RARβ by Reducing DNA Methylation

(2015) Apei Jiang et al.   PHYTOTHERAPY RESEARCH

Consequences of dietary methyl donor supplements: Is more always better?

(2015) Kimberly R. Shorter et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Phenethyl isothiocyanate: A comprehensive review of anti-cancer mechanisms

(2014) Parul Gupta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

The Novel, Small-Molecule DNA Methylation Inhibitor SGI-110 as an Ovarian Cancer Chemosensitizer

(2014) F. Fang et al.   CLINICAL CANCER RESEARCH

Gene promoter methylation in colorectal cancer and healthy adjacent mucosa specimens

(2014) Fabio Coppedè et al.   Epigenetics

Mutations in ZMYND10, a Gene Essential for Proper Axonemal Assembly of Inner and Outer Dynein Arms in Humans and Flies, Cause Primary Ciliary Dyskinesia

(2013) Daniel J. Moore et al.   AMERICAN JOURNAL OF HUMAN GENETICS

DNA Methyltransferase-1 Inhibitors as Epigenetic Therapy for Cancer

(2013) Varinder Singh et al.   CURRENT CANCER DRUG TARGETS

Folate: Metabolism, genes, polymorphisms and the associated diseases

(2013) Fakhira Hassan Nazki et al.   GENE

Expression of DNA Methyltransferases in Breast Cancer Patients and to Analyze the Effect of Natural Compounds on DNA Methyltransferases and Associated Proteins

(2013) Sameer Mirza et al.   Journal of Breast Cancer

Genetic Polymorphisms of MTHFR and Aberrant Promoter Hypermethylation of the RASSF1A Gene in Bladder Cancer Risk in a Chinese Population

(2013) DW Cai et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Mahanine restores RASSF1A expression by down-regulating DNMT1 and DNMT3B in prostate cancer cells

(2013) Soumik Agarwal et al.   Molecular Cancer

Valproic acid shows a potent antitumor effect with alteration of DNA methylation in neuroblastoma

(2012) Song Gu et al.   ANTI-CANCER DRUGS

Epigenetic mechanisms in anti-cancer actions of bioactive food components - the implications in cancer prevention

(2012) B Stefanska et al.   BRITISH JOURNAL OF PHARMACOLOGY

Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins

(2012) Wang Zhiyu et al.   CANCER BIOLOGY & THERAPY

The influence of one-carbon metabolism on gene promoter methylation in a population-based breast cancer study

(2012) Xinran Xu et al.   Epigenetics

Genistein demethylates the promoter of CHD5 and inhibits neuroblastoma growth in vivo

(2012) HUI LI et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation

(2012) Olivia S. Anderson et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Reactivation of RASSF1A in Breast Cancer Cells by Curcumin

(2012) Liping Du et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Trans-Resveratrol Alters Mammary Promoter Hypermethylation in Women at Increased Risk for Breast Cancer

(2012) Weizhu Zhu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells

(2011) Limin Shu et al.   AAPS Journal

Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells

(2011) Barbara Stefanska et al.   BRITISH JOURNAL OF NUTRITION

DNA hypermethylation as a chemotherapy target

(2011) Juan Ren et al.   CELLULAR SIGNALLING

DNA methylation changes associated with cancer risk factors and blood levels of vitamin metabolites in a prospective study

(2011) Paolo Vineis et al.   Epigenetics

Methylation patterns in sentinel genes in peripheral blood cells of heavy smokers: Influence of cruciferous vegetables in an intervention study

(2011) Chiara Scoccianti et al.   Epigenetics

The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal

(2011) Bin Zhao et al.   NATURE CELL BIOLOGY

Interaction between the MTHFR C677T Polymorphism and Alcohol—Impact on Oral Cancer Risk and Multiple DNA Methylation of Tumor-related Genes

(2010) G. Supic et al.   JOURNAL OF DENTAL RESEARCH

Fluorescent Epigenetic Small Molecule Induces Expression of the Tumor Suppressor Ras-Association Domain Family 1A and Inhibits Human Prostate Xenograft

(2010) Kathryn D. Sheikh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Frequent epigenetic inactivation of RASSF2 in thyroid cancer and functional consequences

(2010) Undraga Schagdarsurengin et al.   Molecular Cancer

The RASSF proteins in cancer; from epigenetic silencing to functional characterization

(2009) Antje M. Richter et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

RASSF1A Mediates p21Cip1/Waf1-Dependent Cell Cycle Arrest and Senescence through Modulation of the Raf-MEK-ERK Pathway and Inhibition of Akt

(2009) S. Thaler et al.   CANCER RESEARCH

Frequent hypermethylation of RASSF1A tumour suppressor gene promoter and presence of Merkel cell polyomavirus in small cell lung cancer

(2009) Peter Helmbold et al.   EUROPEAN JOURNAL OF CANCER

The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells

(2009) C Flotho et al.   LEUKEMIA

Methylation status of RASSF1A in patients with chronic myeloid leukemia

(2009) Antigoni Avramouli et al.   LEUKEMIA RESEARCH

Frequent occurrence ofRASSF1Apromoter hypermethylation and merkel cell polyomavirus in merkel cell carcinoma

(2009) Peter Helmbold et al.   MOLECULAR CARCINOGENESIS

Epigenetic Silencing of the RASSF1A Tumor Suppressor Gene through HOXB3-Mediated Induction of DNMT3B Expression

(2009) Rajendra Kumar Palakurthy et al.   MOLECULAR CELL

Soy Isoflavones Have an Antiestrogenic Effect and Alter Mammary Promoter Hypermethylation in Healthy Premenopausal Women

(2009) Wenyi Qin et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Co-enzyme Q10, riboflavin and niacin supplementation on alteration of DNA repair enzyme and DNA methylation in breast cancer patients undergoing tamoxifen therapy

(2008) Vummidi Giridhar Premkumar et al.   BRITISH JOURNAL OF NUTRITION

Inhibition of cytidine deaminase by zebularine enhances the antineoplastic action of 5-aza-2′-deoxycytidine

(2008) Maryse Lemaire et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Quantitative Analysis of DNA Methylation Profiles in Lung Cancer Identifies Aberrant DNA Methylation of Specific Genes and Its Association with Gender and Cancer Risk Factors

(2008) T. Vaissiere et al.   CANCER RESEARCH