Hypaphorine Attenuates Lipopolysaccharide-Induced Endothelial Inflammation via Regulation of TLR4 and PPAR-γ Dependent on PI3K/Akt/mTOR Signal Pathway

Soy-Leaf Extract Exerts Atheroprotective Effects via Modulation of Krüppel-Like Factor 2 and Adhesion Molecules

(2017) Jong-Min Han et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endothelial PPAR-γ provides vascular protection from IL-1β-induced oxidative stress

(2016) Masashi Mukohda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A novel anti-inflammatory mechanism of high density lipoprotein through up-regulating annexin A1 in vascular endothelial cells

(2016) Bing Pan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The breakup of intravascular microbubbles and its impact on the endothelium

(2016) Wolfgang Wiedemair et al.   Biomechanics and Modeling in Mechanobiology

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

Potential therapeutic targets for inflammation in toll-like receptor 4 (TLR4)-mediated signaling pathways

(2016) Anjali Roy et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

N-Oleoylethanolamine Reduces Inflammatory Cytokines and Adhesion Molecules in TNF-α-induced Human Umbilical Vein Endothelial Cells by Activating CB2 and PPAR-α

(2016) Xudong Xu et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

NF-κB-Regulated miR-99a Modulates Endothelial Cell Inflammation

(2016) Mei-hua Bao et al.   MEDIATORS OF INFLAMMATION

Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo

(2016) Hyemee Kim et al.   MOLECULAR CARCINOGENESIS

Urolithin A attenuates ox-LDL-induced endothelial dysfunction partly by modulating microRNA-27 and ERK/PPAR-γ pathway

(2016) Qi-an Han et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The alternative complement pathway is longitudinally associated with adverse cardiovascular outcomes

(2016) Elisabeth Hertle et al.   THROMBOSIS AND HAEMOSTASIS

Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells

(2016) YATING LIU et al.   Oncology Letters

Increased translocation of antigens to endosomes and TLR4 mediated endosomal recruitment of TAP contribute to nicotine augmented cross-presentation

(2016) Yan Yan Wang et al.   Oncotarget

Calcineurin inhibitors cyclosporine A and tacrolimus induce vascular inflammation and endothelial activation through TLR4 signaling

(2016) Raquel Rodrigues-Diez et al.   Scientific Reports

4-O-methylascochlorin suppresses differentiation of 3T3-L1 preadipocytes by inhibiting PPARγ expression through regulation of AMPK/mTOR signaling pathways

(2015) Mihyun Kim et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chronic activation of pattern recognition receptors suppresses brown adipogenesis of multipotent mesodermal stem cells and brown pre-adipocytes

(2015) Jiyoung Bae et al.   Biochemistry and Cell Biology

The role of NADPH Oxidase in Vascular Disease – Hypertension, Atherosclerosis & Stroke

(2015) Stephen Gray et al.   CURRENT PHARMACEUTICAL DESIGN

Isobavachalcone attenuates lipopolysaccharide-induced ICAM-1 expression in brain endothelial cells through blockade of toll-like receptor 4 signaling pathways

(2015) Kwang Min Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological activation of PPAR gamma ameliorates vascular endothelial insulin resistance via a non-canonical PPAR gamma-dependent nuclear factor-kappa B trans-repression pathway

(2015) Ying Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts

(2015) Yunhe Fu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cross-talk between TLR4 and PPARγ pathways in the arachidonic acid-induced inflammatory response in pancreatic acini

(2015) A. Mateu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Exploiting the Pleiotropic Antioxidant Effects of Established Drugs in Cardiovascular Disease

(2015) Sebastian Steven et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RelB activation in anti-inflammatory decidual endothelial cells: a master plan to avoid pregnancy failure?

(2015) Elisa Masat et al.   Scientific Reports

Novel Mechanisms of Endothelial Mechanotransduction

(2014) Jun-ichi Abe et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Systemic Injection of Low-Dose Lipopolysaccharide Fails to Break down the Blood–Brain Barrier or Activate the TLR4-MyD88 Pathway in Neonatal Rat Brain

(2014) Peng Wang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Silica nanoparticles induce autophagy and endothelial dysfunction via the PI3K/Akt/mTOR signaling pathway

(2014) Duan et al.   International Journal of Nanomedicine

Positive Feedback Regulation of Proliferation in Vascular Smooth Muscle Cells Stimulated by Lipopolysaccharide Is Mediated through the TLR 4/Rac1/Akt Pathway

(2014) Dehua Jiang et al.   PLoS One

Xanthine Oxidase Inhibition by Febuxostat Attenuates Experimental Atherosclerosis in Mice

(2014) Johji Nomura et al.   Scientific Reports

Inhibition of Protein Kinase C Delta Attenuates Allergic Airway Inflammation through Suppression of PI3K/Akt/mTOR/HIF-1 Alpha/VEGF Pathway

(2013) Yun Ho Choi et al.   PLoS One

Toll-Like Receptor 4 Activation in Microvascular Endothelial Cells Triggers a Robust Inflammatory Response and Cross Talk With Mononuclear Cells via Interleukin-6

(2012) Zhongyang Lu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

PI3K/Akt contributes to increased expression of Toll-like receptor 4 in macrophages exposed to hypoxic stress

(2012) So Young Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Submaximal PPARγ activation and endothelial dysfunction: new perspectives for the management of cardiovascular disorders

(2012) Pitchai Balakumar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biology and Therapeutic Applications of Peroxisome Proliferator- Activated Receptors

(2012) Maria P. Menendez-Gutierrez et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Endothelial Cell Peroxisome Proliferator-Activated Receptor   Reduces Endotoxemic Pulmonary Inflammation and Injury

(2012) A. T. Reddy et al.   JOURNAL OF IMMUNOLOGY

Cell Adhesion Molecules as Pharmaceutical Target in Atherosclerosis

(2012) S. Ling et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Synthesis and Bioactivity of Secondary Metabolites from Marine Sponges Containing Dibrominated Indolic Systems

(2012) Adriano Mollica et al.   MOLECULES

PPAR  attenuates intimal hyperplasia by inhibiting TLR4-mediated inflammation in vascular smooth muscle cells

(2011) L.-L. Zhang et al.   CARDIOVASCULAR RESEARCH

PPARγ agonist rosiglitazone ameliorates LPS-induced inflammation in vascular smooth muscle cells via the TLR4/TRIF/IRF3/IP-10 signaling pathway

(2011) Yuanyuan Ji et al.   CYTOKINE

PPARs and the Cardiovascular System

(2008) Milton Hamblin et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypaphorine, an indole alkaloid from Erythrina velutina, induced sleep on normal mice

(2008) Masaaki Ozawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS