Influenza A Virus–Host Protein Interactions Control Viral Pathogenesis

Attacked from All Sides: RNA Decay in Antiviral Defense

(2017) Jerome Molleston et al.   Viruses-Basel

CNOT4-Mediated Ubiquitination of Influenza A Virus Nucleoprotein Promotes Viral RNA Replication

(2017) Yu-Chen Lin et al.   mBio

Comparative influenza protein interactomes identify the role of plakophilin 2 in virus restriction

(2017) Lingyan Wang et al.   Nature Communications

NF90 is a novel influenza A virus NS1-interacting protein that antagonizes the inhibitory role of NS1 on PKR phosphorylation

(2016) Ting Li et al.   FEBS LETTERS

Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

(2016) Nicholas S. Heaton et al.   IMMUNITY

DDX3 Interacts with Influenza A Virus NS1 and NP Proteins and Exerts Antiviral Function through Regulation of Stress Granule Formation

(2016) Sathya N. Thulasi Raman et al.   JOURNAL OF VIROLOGY

Species difference in ANP32A underlies influenza A virus polymerase host restriction

(2016) Jason S. Long et al.   NATURE

Influenza A Virus-induced expression of ISG20 inhibits viral replication by interacting with nucleoprotein

(2016) Hongren Qu et al.   VIRUS GENES

NXT1, a Novel Influenza A NP Binding Protein, Promotes the Nuclear Export of NP via a CRM1-Dependent Pathway

(2016) Nopporn Chutiwitoonchai et al.   Viruses-Basel

Meta- and Orthogonal Integration of Influenza “OMICs” Data Defines a Role for UBR4 in Virus Budding

(2015) Shashank Tripathi et al.   Cell Host & Microbe

Molecular Determinants for Nuclear Import of Influenza A PB2 by Importin α Isoforms 3 and 7

(2015) Ruth A. Pumroy et al.   STRUCTURE

TRIM32 Senses and Restricts Influenza A Virus by Ubiquitination of PB1 Polymerase

(2015) Bishi Fu et al.   PLoS Pathogens

pp32 and APRIL are host cell-derived regulators of influenza virus RNA synthesis from cRNA

(2015) Kenji Sugiyama et al.   eLife

Influenza Virus-Host Interactome Screen as a Platform for Antiviral Drug Development

(2014) Tokiko Watanabe et al.   Cell Host & Microbe

Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

(2014) Guifang Chen et al.   Cell Host & Microbe

CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2

(2014) Yong Hu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Heat Shock Protein 70 Modulates Influenza A Virus Polymerase Activity

(2014) Rashid Manzoor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Functional Site in the PB2 Subunit of Influenza A Virus Essential for Acetyl-CoA Interaction, RNA Polymerase Activity, and Viral Replication

(2014) Dai Hatakeyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DnaJA1/Hsp40 Is Co-Opted by Influenza A Virus To Enhance Its Viral RNA Polymerase Activity

(2014) M. Cao et al.   JOURNAL OF VIROLOGY

Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication

(2014) A. York et al.   JOURNAL OF VIROLOGY

Interaction of NS2 with AIMP2 Facilitates the Switch from Ubiquitination to SUMOylation of M1 in Influenza A Virus-Infected Cells

(2014) Shijuan Gao et al.   JOURNAL OF VIROLOGY

Quantitative Proteomic Analysis of the Influenza A Virus Nonstructural Proteins NS1 and NS2 during Natural Cell Infection Identifies PACT as an NS1 Target Protein and Antiviral Host Factor

(2014) K. Tawaratsumida et al.   JOURNAL OF VIROLOGY

Structural insight into cap-snatching and RNA synthesis by influenza polymerase

(2014) Stefan Reich et al.   NATURE

Structure of influenza A polymerase bound to the viral RNA promoter

(2014) Alexander Pflug et al.   NATURE

NLRX1 prevents mitochondrial induced apoptosis and enhances macrophage antiviral immunity by interacting with influenza virus PB1-F2 protein

(2014) J. Jaworska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of paramyxovirus membrane fusion and virus entry

(2014) Theodore S Jardetzky et al.   Current Opinion in Virology

Recruitment of RED-SMU1 Complex by Influenza A Virus RNA Polymerase to Control Viral mRNA Splicing

(2014) Guillaume Fournier et al.   PLoS Pathogens

NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL

(2013) Masaya Miyazaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRIM22 Inhibits Influenza A Virus Infection by Targeting the Viral Nucleoprotein for Degradation

(2013) A. Di Pietro et al.   JOURNAL OF VIROLOGY

Synergistic Effect of the PDZ and p85 -Binding Domains of the NS1 Protein on Virulence of an Avian H5N1 Influenza A Virus

(2013) S. Fan et al.   JOURNAL OF VIROLOGY

The Influenza Virus Protein PB1-F2 Interacts with IKKβ and Modulates NF-κB Signalling

(2013) Ana Luísa Reis et al.   PLoS One

The Interactomes of Influenza Virus NS1 and NS2 Proteins Identify New Host Factors and Provide Insights for ADAR1 Playing a Supportive Role in Virus Replication

(2013) Benoît de Chassey et al.   PLoS Pathogens

Cellular RNA Binding Proteins NS1-BP and hnRNP K Regulate Influenza A Virus RNA Splicing

(2013) Pei-Ling Tsai et al.   PLoS Pathogens

Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK

(2012) Shijuan Gao et al.   CELLULAR MICROBIOLOGY

HMGB1 Protein Binds to Influenza Virus Nucleoprotein and Promotes Viral Replication

(2012) D. Moisy et al.   JOURNAL OF VIROLOGY

The NS1 Protein of Influenza A Virus Interacts with Cellular Processing Bodies and Stress Granules through RNA-Associated Protein 55 (RAP55) during Virus Infection

(2012) B. W.-Y. Mok et al.   JOURNAL OF VIROLOGY

Cellular Protein HAX1 Interacts with the Influenza A Virus PA Polymerase Subunit and Impedes Its Nuclear Translocation

(2012) W.-B. Hsu et al.   JOURNAL OF VIROLOGY

A Second CRM1-Dependent Nuclear Export Signal in the Influenza A Virus NS2 Protein Contributes to the Nuclear Export of Viral Ribonucleoproteins

(2012) S. Huang et al.   JOURNAL OF VIROLOGY

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Viral immune modulators perturb the human molecular network by common and unique strategies

(2012) Andreas Pichlmair et al.   NATURE

Regulation of Interferon-β by MAGI-1 and Its Interaction with Influenza A Virus NS1 Protein with ESEV PBM

(2012) Manish Kumar et al.   PLoS One

Influenza Virus A/Beijing/501/2009(H1N1) NS1 Interacts with β-Tubulin and Induces Disruption of the Microtubule Network and Apoptosis on A549 Cells

(2012) Xueqing Han et al.   PLoS One

F1Fo-ATPase, F-type proton-translocating ATPase, at the plasma membrane is critical for efficient influenza virus budding

(2012) T. Gorai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)

(2012) Duncan Paterson et al.   PLoS Pathogens

Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

(2012) Ricardo Rajsbaum et al.   PLoS Pathogens

Human-like PB2 627K Influenza Virus Polymerase Activity Is Regulated by Importin-α1 and -α7

(2012) Ben Hudjetz et al.   PLoS Pathogens

The pathogenesis of influenza virus infections: the contributions of virus and host factors

(2011) Satoshi Fukuyama et al.   CURRENT OPINION IN IMMUNOLOGY

Interaction of the Influenza A Virus Polymerase PB2 C-terminal Region with Importin α Isoforms Provides Insights into Host Adaptation and Polymerase Assembly

(2011) Stephane Boivin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Virulence determinants of pandemic influenza viruses

(2011) Donna M. Tscherne et al.   JOURNAL OF CLINICAL INVESTIGATION

Cellular Human CLE/C14orf166 Protein Interacts with Influenza Virus Polymerase and Is Required for Viral Replication

(2011) A. Rodriguez et al.   JOURNAL OF VIROLOGY

The Avian Influenza Virus NS1 ESEV PDZ Binding Motif Associates with Dlg1 and Scribble To Disrupt Cellular Tight Junctions

(2011) L. Golebiewski et al.   JOURNAL OF VIROLOGY

Identification of RNA Helicase A as a Cellular Factor That Interacts with Influenza A Virus NS1 Protein and Its Role in the Virus Life Cycle

(2011) L. Lin et al.   JOURNAL OF VIROLOGY

Global landscape of HIV–human protein complexes

(2011) Stefanie Jäger et al.   NATURE

Influenza A Virus Nucleoprotein Exploits Hsp40 to Inhibit PKR Activation

(2011) Kulbhushan Sharma et al.   PLoS One

PDlim2 Selectively Interacts with the PDZ Binding Motif of Highly Pathogenic Avian H5N1 Influenza A Virus NS1

(2011) Jia Yu et al.   PLoS One

The NS1 protein of influenza a virus interacts with heat shock protein Hsp90 in human alveolar basal epithelial cells: Implication for virus-induced apoptosis

(2011) Chuanfu Zhang et al.   Virology Journal

The distinct binding properties between avian/human influenza A virus NS1 and Postsynaptic density protein-95 (PSD-95), and inhibition of nitric oxide production

(2011) Heng Zhang et al.   Virology Journal

Analysis of the PDZ binding specificities of Influenza A Virus NS1 proteins

(2011) Miranda Thomas et al.   Virology Journal

The Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon at the Level of the MAVS Adaptor Protein

(2011) Zsuzsanna T. Varga et al.   PLoS Pathogens

The non-structural (NS1) protein of influenza A virus associates with p53 and inhibits p53-mediated transcriptional activity and apoptosis

(2010) Xiaodu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of the interaction of influenza virus NS1 with Akt

(2010) Mami Matsuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Influenza Virus M2 Protein Mediates ESCRT-Independent Membrane Scission

(2010) Jeremy S. Rossman et al.   CELL

Crucial role of the influenza virus NS2 (NEP) C-terminal domain in M1 binding and nuclear export of vRNP

(2010) Teppei Shimizu et al.   FEBS LETTERS

Influenza A Virus Polymerase Inhibits Type I Interferon Induction by Binding to Interferon β Promoter Stimulator 1

(2010) Atsushi Iwai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human cellular protein nucleoporin hNup98 interacts with influenza A virus NS2/nuclear export protein and overexpression of its GLFG repeat domain can inhibit virus propagation

(2010) J. Chen et al.   JOURNAL OF GENERAL VIROLOGY

Species-Specific Contribution of the Four C-Terminal Amino Acids of Influenza A Virus NS1 Protein to Virulence

(2010) S. M. Soubies et al.   JOURNAL OF VIROLOGY

Cyclin T1/CDK9 Interacts with Influenza A Virus Polymerase and Facilitates Its Association with Cellular RNA Polymerase II

(2010) J. Zhang et al.   JOURNAL OF VIROLOGY

Inefficient Control of Host Gene Expression by the 2009 Pandemic H1N1 Influenza A Virus NS1 Protein

(2010) B. G. Hale et al.   JOURNAL OF VIROLOGY

Virulence Determinants of Avian H5N1 Influenza A Virus in Mammalian and Avian Hosts: Role of the C-Terminal ESEV Motif in the Viral NS1 Protein

(2010) Florian Zielecki et al.   JOURNAL OF VIROLOGY

Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation

(2010) J. S. Rossman et al.   JOURNAL OF VIROLOGY

The ESEV PDZ-Binding Motif of the Avian Influenza A Virus NS1 Protein Protects Infected Cells from Apoptosis by Directly Targeting Scribble

(2010) H. Liu et al.   JOURNAL OF VIROLOGY

The PB2 Subunit of the Influenza Virus RNA Polymerase Affects Virulence by Interacting with the Mitochondrial Antiviral Signaling Protein and Inhibiting Expression of Beta Interferon

(2010) K. M. Graef et al.   JOURNAL OF VIROLOGY

SAINT: probabilistic scoring of affinity purification–mass spectrometry data

(2010) Hyungwon Choi et al.   NATURE METHODS

The cytoplasmic domain of influenza M2 protein interacts with caveolin-1

(2009) Peng Zou et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Defining the Human Deubiquitinating Enzyme Interaction Landscape

(2009) Mathew E. Sowa et al.   CELL

A Physical and Regulatory Map of Host-Influenza Interactions Reveals Pathways in H1N1 Infection

(2009) Sagi D. Shapira et al.   CELL

Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication

(2009) Xiaoling Liu et al.   CELLULAR MICROBIOLOGY

Innate immune evasion strategies of influenza viruses

(2009) Benjamin G Hale et al.   Future Microbiology

NS2/NEP protein regulates transcription and replication of the influenza virus RNA genome

(2009) Nicole C. Robb et al.   JOURNAL OF GENERAL VIROLOGY

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA

(2009) J. Zhang et al.   JOURNAL OF GENERAL VIROLOGY

RuvB-Like Protein 2 Is a Suppressor of Influenza A Virus Polymerases

(2009) S. Kakugawa et al.   JOURNAL OF VIROLOGY

The multifunctional NS1 protein of influenza A viruses

(2008) B. G. Hale et al.   JOURNAL OF GENERAL VIROLOGY

The Influenza Virus M2 Protein Cytoplasmic Tail Interacts with the M1 Protein and Influences Virus Assembly at the Site of Virus Budding

(2008) B. J. Chen et al.   JOURNAL OF VIROLOGY

Interaction of Polymerase Subunit PB2 and NP with Importin α1 Is a Determinant of Host Range of Influenza A Virus

(2008) Gülsah Gabriel et al.   PLoS Pathogens

Structural basis for suppression of a host antiviral response by influenza A virus

(2008) K. Das et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A new influenza virus virulence determinant: The NS1 protein four C-terminal residues modulate pathogenicity

(2008) D. Jackson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE