Gene Therapy for Pancreatic Cancer: Specificity, Issues and Hopes

Current application of CRISPR/Cas9 gene-editing technique to eradication of HIV/AIDS

(2017) Z Huang et al.   GENE THERAPY

The role of stromal cancer-associated fibroblasts in pancreatic cancer

(2017) Dagny von Ahrens et al.   Journal of Hematology & Oncology

CAR T-cell therapy for pancreatic cancer

(2017) Carl J. DeSelm et al.   JOURNAL OF SURGICAL ONCOLOGY

Improving Chimeric Antigen Receptor-Modified T Cell Function by Reversing the Immunosuppressive Tumor Microenvironment of Pancreatic Cancer

(2017) Somala Mohammed et al.   MOLECULAR THERAPY

Recent Advances in Nanomaterials for Gene Delivery—A Review

(2017) Michael Riley et al.   Nanomaterials

Vectorized Gene Therapy of Liver Tumors: Proof of Concept of TG4023 (MVA-FCU1) in Combination with Flucytosine

(2016) F. Husseini et al.   ANNALS OF ONCOLOGY

Infiltrating immune cells and gene mutations in pancreatic ductal adenocarcinoma

(2016) W.-Q. Wang et al.   BRITISH JOURNAL OF SURGERY

T-cell programming in pancreatic adenocarcinoma: a review

(2016) Y D Seo et al.   CANCER GENE THERAPY

Multiplex Genome Editing to Generate Universal CAR T Cells Resistant to PD1 Inhibition

(2016) Jiangtao Ren et al.   CLINICAL CANCER RESEARCH

Targeting KRAS for diagnosis, prognosis, and treatment of pancreatic cancer: Hopes and realities

(2016) Barbara Bournet et al.   EUROPEAN JOURNAL OF CANCER

Initial Characterization of Integrase-Defective Lentiviral Vectors for Pancreatic Cancer Gene Therapy

(2016) Naima Hanoun et al.   HUMAN GENE THERAPY

The Promise of Gene Therapy for Pancreatic Cancer

(2016) Georges Vassaux et al.   HUMAN GENE THERAPY

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

(2016) Avery D. Posey et al.   IMMUNITY

Mesothelin as a target for chimeric antigen receptor-modified T cells as anticancer therapy

(2016) Mark O'Hara et al.   Immunotherapy

Randomized Phase 2 Trial of the Oncolytic Virus Pelareorep (Reolysin) in Upfront Treatment of Metastatic Pancreatic Adenocarcinoma

(2016) Anne M Noonan et al.   MOLECULAR THERAPY

A multifunctional AAV–CRISPR–Cas9 and its host response

(2016) Wei Leong Chew et al.   NATURE METHODS

Oncolytic viruses against cancer stem cells: A promising approach for gastrointestinal cancer

(2016) Fang Huang et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Immune checkpoint therapy for pancreatic cancer

(2016) Henrik Johansson et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Oncolytic Viruses: Therapeutics With an Identity Crisis

(2016) Caroline J. Breitbach et al.   EBioMedicine

Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma

(2015) Laura K. Aguilar et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR/Cas9-mediated somatic genome editing

(2015) Shin-Heng Chiou et al.   GENES & DEVELOPMENT

Targeted Oncolytic Herpes Simplex Virus Type 1 Eradicates Experimental Pancreatic Tumors

(2015) Marion Gayral et al.   HUMAN GENE THERAPY

Safety and Survival With GVAX Pancreas Prime and Listeria Monocytogenes–Expressing Mesothelin (CRS-207) Boost Vaccines for Metastatic Pancreatic Cancer

(2015) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Talimogene Laherparepvec Improves Durable Response Rate in Patients With Advanced Melanoma

(2015) Robert H.I. Andtbacka et al.   JOURNAL OF CLINICAL ONCOLOGY

First-in-man Phase 1 Clinical Trial of Gene Therapy for Advanced Pancreatic Cancer: Safety, Biodistribution, and Preliminary Clinical Findings

(2015) Louis Buscail et al.   MOLECULAR THERAPY

Whole genomes redefine the mutational landscape of pancreatic cancer

(2015) Nicola Waddell et al.   NATURE

Reciprocal cellular cross-talk within the tumor microenvironment promotes oncolytic virus activity

(2015) Carolina S Ilkow et al.   NATURE MEDICINE

Hexon Modification to Improve the Activity of Oncolytic Adenovirus Vectors against Neoplastic and Stromal Cells in Pancreatic Cancer

(2015) Tanja Lucas et al.   PLoS One

Microenvironmental regulation of therapeutic response in cancer

(2015) Florian Klemm et al.   TRENDS IN CELL BIOLOGY

RNAi therapy targeting KRAS in combination with chemotherapy for locally advanced pancreatic cancer patients

(2015) Talia Golan et al.   Oncotarget

Pancreatic Adenocarcinoma

(2015) David P. Ryan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Gene therapy in pancreatic cancer

(2014) Si-Xue Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Trial Watch

(2014) Jonathan Pol et al.   OncoImmunology

Trial Watch:

(2014) Jonathan Pol et al.   OncoImmunology

Encapsulated Cells Expressing a Chemotherapeutic Activating Enzyme Allow the Targeting of Subtoxic Chemotherapy and Are Safe and Efficacious: Data from Two Clinical Trials in Pancreatic Cancer

(2014) J. Löhr et al.   Pharmaceutics

Viral therapy for pancreatic cancer: Tackle the bad guys with poison

(2013) Can Xu et al.   CANCER LETTERS

Role of the immune system in pancreatic cancer progression and immune modulating treatment strategies

(2013) K. Sideras et al.   CANCER TREATMENT REVIEWS

Roles for KRAS in Pancreatic Tumor Development and Progression

(2013) Marina Pasca di Magliano et al.   GASTROENTEROLOGY

Randomized Phase III Multi-Institutional Study of TNFerade Biologic With Fluorouracil and Radiotherapy for Locally Advanced Pancreatic Cancer: Final Results

(2013) Joseph M. Herman et al.   JOURNAL OF CLINICAL ONCOLOGY

Evaluation of Ipilimumab in Combination With Allogeneic Pancreatic Tumor Cells Transfected With a GM-CSF Gene in Previously Treated Pancreatic Cancer

(2013) Dung T. Le et al.   JOURNAL OF IMMUNOTHERAPY

Targeting miR-21 for the Therapy of Pancreatic Cancer

(2013) Flavie Sicard et al.   MOLECULAR THERAPY

Increased Survival in Pancreatic Cancer with nab-Paclitaxel plus Gemcitabine

(2013) Daniel D. Von Hoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Experimental studies on treatment of pancreatic cancer with double-regulated duplicative adenovirus AdTPHre-hEndo carrying human endostatin gene

(2013) Yun-feng Shan et al.   PANCREATOLOGY

Oncosuppressive Suicide Gene Virotherapy “PVH1-yCD/5-FC” for Pancreatic Peritoneal Carcinomatosis Treatment: NFκB and Akt/PI3K Involvement

(2013) Soukaina Réjiba et al.   PLoS One

Gemcitabine-mediated tumour regression and p53-dependent gene expression: implications for colon and pancreatic cancer therapy

(2013) R Hill et al.   Cell Death & Disease

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

(2012) Karsten Geletneky et al.   BMC CANCER

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

Phase 1/2a, dose-escalation, safety, pharmacokinetic and preliminary efficacy study of intratumoral administration of BC-819 in patients with unresectable pancreatic cancer

(2012) N Hanna et al.   CANCER GENE THERAPY

EUS or percutaneously guided intratumoral TNFerade biologic with 5-fluorouracil and radiotherapy for first-line treatment of locally advanced pancreatic cancer: a phase I/II study

(2012) J. Randolph Hecht et al.   GASTROINTESTINAL ENDOSCOPY

Mutated Ras-Transfected, EBV-Transformed Lymphoblastoid Cell Lines as a Model Tumor Vaccine for Boosting T-Cell Responses Against Pancreatic Cancer: A Pilot Trial

(2012) Boris Kubuschok et al.   HUMAN GENE THERAPY

Addition of Algenpantucel-L Immunotherapy to Standard Adjuvant Therapy for Pancreatic Cancer: a Phase 2 Study

(2012) Jeffrey M. Hardacre et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Delivery of interferon alpha using a novel Cox2-controlled adenovirus for pancreatic cancer therapy

(2012) Leonard Armstrong et al.   SURGERY

Overview of cancer vaccines

(2012) Alex Kudrin   Human Vaccines & Immunotherapeutics

A Lethally Irradiated Allogeneic Granulocyte-Macrophage Colony Stimulating Factor-Secreting Tumor Vaccine for Pancreatic Adenocarcinoma

(2011) Lutz Eric et al.   ANNALS OF SURGERY

An oncolytic adenovirus defective in pRb-binding (dl922–947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine

(2011) M Bhattacharyya et al.   CANCER GENE THERAPY

Histidinylated linear PEI: a new efficient non-toxic polymer for gene transfer

(2011) Emilie Bertrand et al.   CHEMICAL COMMUNICATIONS

A phase I pilot trial of MUC1-peptide-pulsed dendritic cells in the treatment of advanced pancreatic cancer

(2011) Yefei Rong et al.   CLINICAL AND EXPERIMENTAL MEDICINE

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

(2011) D. T. Le et al.   CLINICAL CANCER RESEARCH

Genetic and Epigenetic Alterations in Pancreatic Carcinogenesis

(2011) Yannick Delpu et al.   CURRENT GENOMICS

Oncolytic virotherapy for pancreatic cancer

(2011) Sonia Wennier et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

FOLFIRINOX versus Gemcitabine for Metastatic Pancreatic Cancer

(2011) Thierry Conroy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Whole-exome sequencing of neoplastic cysts of the pancreas reveals recurrent mutations in components of ubiquitin-dependent pathways

(2011) J. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Review article: gene therapy, recent developments and future prospects in gastrointestinal oncology

(2010) Y. Touchefeu et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

A phase I dose-escalation clinical trial of intraoperative direct intratumoral injection of HF10 oncolytic virus in non-resectable patients with advanced pancreatic cancer

(2010) A Nakao et al.   CANCER GENE THERAPY

Reactivation of p53 by Novel MDM2 Inhibitors: Implications for Pancreatic Cancer Therapy

(2010) A.S. Azmi et al.   CURRENT CANCER DRUG TARGETS

Therapeutic Potential of Poly(ADP-ribose) Polymerase Inhibitor AG014699 in Human Cancers With Mutated or Methylated BRCA1 or BRCA2

(2010) Yvette Drew et al.   JNCI-Journal of the National Cancer Institute

Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia

(2010) Marina Cavazzana-Calvo et al.   NATURE

Efficacy of Gene Therapy for X-Linked Severe Combined Immunodeficiency

(2010) Salima Hacein-Bey-Abina et al.   NEW ENGLAND JOURNAL OF MEDICINE

COSMIC: mining complete cancer genomes in the Catalogue of Somatic Mutations in Cancer

(2010) S. A. Forbes et al.   NUCLEIC ACIDS RESEARCH

Influence of Cell Cycle Checkpoints and p53 Function on the Toxicity of Temozolomide in Human Pancreatic Cancer Cells

(2010) Seema Gupta et al.   PANCREATOLOGY

Local and Distant Immunity Induced by Intralesional Vaccination with an Oncolytic Herpes Virus Encoding GM-CSF in Patients with Stage IIIc and IV Melanoma

(2009) Howard L. Kaufman et al.   ANNALS OF SURGICAL ONCOLOGY

Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

(2009) Patrick Midoux et al.   BRITISH JOURNAL OF PHARMACOLOGY

Using lentiviral vectors for efficient pancreatic cancer gene therapy

(2009) E Ravet et al.   CANCER GENE THERAPY

Combination of human tumor necrosis factor-alpha (hTNF-α) gene delivery with gemcitabine is effective in models of pancreatic cancer

(2009) S R Murugesan et al.   CANCER GENE THERAPY

Improvement of Gemcitabine-Based Therapy of Pancreatic Carcinoma by Means of Oncolytic Parvovirus H-1PV

(2009) A. L. Angelova et al.   CLINICAL CANCER RESEARCH

Lister strain of vaccinia virus armed with endostatin–angiostatin fusion gene as a novel therapeutic agent for human pancreatic cancer

(2009) J R Tysome et al.   GENE THERAPY

Alkylcarboxylate grafting to polyethylenimine: a simple approach to producing a DNA nanocarrier with low toxicity

(2009) Reza K. Oskuee et al.   JOURNAL OF GENE MEDICINE

Advanced Phase I/II Studies of Targeted Gene Delivery In Vivo: Intravenous Rexin-G for Gemcitabine-resistant Metastatic Pancreatic Cancer

(2009) Sant P Chawla et al.   MOLECULAR THERAPY

Preclinical study of an ex vivo gene therapy protocol for hepatocarcinoma

(2008) B Lortal et al.   CANCER GENE THERAPY

Allogeneic Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Immunotherapy Alone or in Sequence with Cyclophosphamide for Metastatic Pancreatic Cancer: A Pilot Study of Safety, Feasibility, and Immune Activation

(2008) D. Laheru et al.   CLINICAL CANCER RESEARCH

Phase I Trial of a Pathotropic Retroviral Vector Expressing a Cytocidal Cyclin G1 Construct (Rexin-G) in Patients With Advanced Pancreatic Cancer

(2008) Evanthia Galanis et al.   MOLECULAR THERAPY

Pancreatic Carcinogenesis

(2008) Jan-Bart M. Koorstra et al.   PANCREATOLOGY

Inhibition of pancreatic carcinoma cell growth in vitro by DPC4 gene transfection

(2008) Wei Shen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides

(2008) Yong-Mei Shen et al.   WORLD JOURNAL OF GASTROENTEROLOGY