Review
Oncology
Bircan Coban, Cecilia Bergonzini, Annelien J. M. Zweemer, Erik H. J. Danen
Summary: This article discusses the mechanisms of tumor cell metastasis, highlighting how epithelial-to-mesenchymal transition and mechanical changes in the tumor microenvironment affect the dissemination of tumor cells. Targeting tumor cell plasticity may provide therapeutic opportunities to combat metastasis.
BRITISH JOURNAL OF CANCER
(2021)
Review
Immunology
Hideaki Fujiwara
Summary: This article discusses the impact of allo-HSCT on intestinal microbiota and metabolites, as well as the mechanisms for regulating experimental GVHD through dietary intervention or metabolites produced by intestinal bacteria post-allo-HSCT. It also summarizes the major findings of microbiome-based immunotherapeutic approaches for tissue protection against experimental GVHD. Understanding the complex relationships within the gut microbiota-metabolites-host tissues axis is crucial for insight into GVHD pathogenesis and the development of new therapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Chang-Hyeon Kim, Da-Eun Kim, Dae-Hoon Kim, Ga-Hong Min, Jung-Won Park, Yeo-Bin Kim, Chang K. Sung, Hyungshin Yim
Summary: Accumulating evidence suggests that mitotic protein kinases play a role in both metastatic migration and tumorigenesis. Understanding the contribution of cytoskeletal proteins to cell division and metastatic motility is crucial for effective treatment of cancer metastases.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2022)
Article
Engineering, Environmental
Yuanyuan Wang, Fengbang Wang, Zihan Chen, Maoyong Song, Xinglei Yao, Guibin Jiang
Summary: In this study, a high-throughput single-cell imaging method was used to investigate the crosstalk among quantum dot-induced ROS generation, apoptosis, and changes in nucleus size in macrophages. Results indicated a positive correlation between changes in nucleus size and ROS generation, with QDot exposure leading to ROS generation, cell apoptosis, and subsequent changes in nucleus size. These findings provide detailed insights into the heterogeneity of nanoparticle exposure in cellular responses.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Developmental Biology
Jessica D. Manneken, Peter D. Currie
Summary: The cells of the innate immune system, particularly macrophages, play a vital role in tissue repair and stem cell activation. Recent studies have revealed the complex molecular processes involved in these mechanisms and the direct role of immune cells in coordinating these processes.
Article
Chemistry, Multidisciplinary
Ashok Kumar Dhinakaran, Priya Dharmalingam, Swarna Ganesh, Krishnan Venkatakrishnan, Sunit Das, Bo Tan
Summary: This study highlights the potential of T cells as diagnostic markers for glioblastoma. By studying the phenotypic and immunological changes in T cells, two clinically validated biomarkers, GBMAT and GSCAT, were established. These biomarkers demonstrated high sensitivity and specificity in diagnosing GBM, and were further validated using a machine learning algorithm.
Review
Cell Biology
Di Lu, Yan Xu, Qiuli Liu, Qi Zhang
Summary: Macrophages play crucial roles in biological systems, while mesenchymal stem cells show promise in immune-related disease treatments due to their ability to regulate immune cells. The interaction between MSCs and macrophages through various methods is important in disease development and maintaining stability in inflammatory microenvironments. Strategies for optimal applications in immune-related disease treatments are discussed.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jorrit M. Enserink, Pierre Chymkowitch
Summary: Cdk1 is a master regulator of the cell cycle, controlling progression through different phases. It also directly regulates RNA polymerase activity, which is important for protein synthesis and meeting cellular demands. This regulation promotes cell cycle entry.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Dai Li, Xueqiang Peng, Guangpeng He, Jiaxing Liu, Xian Li, Weikai Lin, Jianjun Fang, Xinyu Li, Shuo Yang, Liang Yang, Hangyu Li
Summary: Cancer stem cells play a crucial role in tumorigenesis, progression, recurrence, and possess unique metabolic characteristics. Autophagy, a catabolic process that helps cells survive under stressful conditions, has been extensively studied in cancer cells, but its potential relationship with cancer stem cells has not been fully explored. This study summarizes the possible roles of autophagy in the functions of cancer stem cells, including renewal, proliferation, differentiation, survival, metastasis, invasion, and treatment resistance.
CELL DEATH & DISEASE
(2023)
Review
Biochemistry & Molecular Biology
Shinichi Saitoh, Koen Van Wijk, Osamu Nakajima
Summary: Metabolic syndrome is caused by insulin resistance and multiple risk factors. Chronic inflammation due to obesity is primarily caused by pro-inflammatory M1 macrophages entering adipose tissue, which in turn recruit more pro-inflammatory immune cells to enhance the immune response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yeongjoo Kim, Seungjae Shin, Sunyoung Kwon, Kisung Moon, Su -Vin Baek, Ahyoung Jo, Hyung-Sik Kim, Gue-Ho Hwang, Sangsu Bae, Yun Hak Kim, Sung-Yup Cho, Jung-Min Oh
Summary: N-6-methyladenosine (m6A) modification in RNA affects gene expression and RNA metabolism. This modification is regulated by various proteins, including writers, erasers, and readers. In this study, the authors investigated the effects of m6A modification on alternative splicing in cancer cells and found that METTL3 regulates m6A-dependent alternative splicing, particularly in cell cycle-related genes, through the modulation of splicing factors such as SFPQ.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Lei Ye, Yi Jiang, Mingming Zhang
Summary: Metabolites of glycolytic metabolism play roles as signaling molecules and regulators of gene expression in immune cells. Recent studies have revealed the non-metabolic signaling functions of intermediates of the mitochondrial pathway and glycolysis. Lactate, as the end product of glycolysis, plays important roles in immune cell biology and associated pathologies.
CYTOKINE & GROWTH FACTOR REVIEWS
(2022)
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Xingting Bao, Jinhua Zhang, Guomin Huang, Junfang Yan, Caipeng Xu, Zhihui Dou, Chao Sun, Hong Zhang
Summary: Mitochondria play a crucial role in cellular functions, while HIFs and mitochondrial dysfunction are interconnected and contribute to complex energy metabolism remodeling in cancer development. The crosstalk between HIFs and mitochondrial functions is part of an extensive and cooperative network that regulates tumorigenesis and development.
CELL DEATH & DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Xiaodong Niu, Yuan Yang, Yanming Ren, Shengtao Zhou, Qing Mao, Yuan Wang
Summary: The m(6)A modification, a prevalent and abundant RNA modification, is involved in the occurrence and development of various cancers. Recent studies have shown that aberrant m(6)A regulators and m(6)A levels have dual effects on cancer progression, acting as both promoters and inhibitors. Additionally, direct interactions between different m(6)A regulators and mRNAs have been observed in various cancers. This review summarizes the functions of m(6)A regulators and their roles in different types of cancers, and discusses the potential clinical applications of targeting m(6)A regulators.
Article
Cell & Tissue Engineering
Michael S. Kareta, Laura L. Gorges, Sana Hafeez, Berenice A. Benayoun, Samuele Marro, Anne-Flore Zmoos, Matthew J. Cecchini, Damek Spacek, Luis F. Z. Batista, Megan O'Brien, Yi-Han Ng, Cheen Euong Ang, Dedeepya Vaka, Steven E. Artandi, Frederick A. Dick, Anne Brunet, Julien Sage, Marius Wernig
Meeting Abstract
Oncology
Michael S. Kareta, Megan O'Brien, Marius Wernig, Julien Sage
MOLECULAR CANCER RESEARCH
(2016)
Article
Cell Biology
Nadine S. Jahchan, Jing Shan Lim, Becky Bola, Karen Morris, Garrett Seitz, Kim Q. Tran, Lei Xu, Francesca Trapani, Christopher J. Morrow, Sandra Cristea, Garry L. Coles, Dian Yang, Dedeepya Vaka, Michael S. Kareta, Julie George, Pawel K. Mazur, Thuyen Nguyen, Wade C. Anderson, Scott J. Dylla, Fiona Blackhall, Martin Peifer, Caroline Dive, Julien Sage
Article
Multidisciplinary Sciences
Moritz Mall, Michael S. Kareta, Soham Chanda, Henrik Ahlenius, Nicholas Perotti, Bo Zhou, Sarah D. Grieder, Xuecai Ge, Sienna Drake, Cheen Euong Ang, Brandon M. Walker, Thomas Vierbuchen, Daniel R. Fuentes, Philip Brennecke, Kazuhiro R. Nitta, Arttu Jolma, Lars M. Steinmetz, Jussi Taipale, Thomas C. Sudhof, Marius Wernig
Article
Biochemistry & Molecular Biology
Nataliya Nady, Alexander Lemak, John R. Walker, George V. Avvakumov, Michael S. Kareta, Mayada Achour, Sheng Xue, Shili Duan, Abdellah Allali-Hassani, Xiaobing Zuo, Yun-Xing Wang, Christian Bronner, Frederic Chedin, Cheryl H. Arrowsmith, Sirano Dhe-Paganon
JOURNAL OF BIOLOGICAL CHEMISTRY
(2011)
Article
Genetics & Heredity
Deborah L. Burkhart, Stacey E. Wirt, Anne-Flore Zmoos, Michael S. Kareta, Julien Sage
Editorial Material
Multidisciplinary Sciences
Michael S. Kareta, Julien Sage
Article
Biology
Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R. Nery, Moritz Malin, Michael S. Kareta, Sean M. Cullen, Margaret A. Goodell, Howard Y. Chang, Marius Wernig, Joseph R. Ecker
Article
Oncology
Sany Hoxha, Alyssa Shepard, Scott Troutman, Huitian Diao, Joanne R. Doherty, Michalina Janiszewska, Robert M. Witwicki, Matthew E. Pipkin, William W. Ja, Michael S. Kareta, Joseph L. Kissil
Article
Cell Biology
Qian Yi Lee, Moritz Mall, Soham Chanda, Bo Zhou, Kylesh S. Sharma, Katie Schaukowitch, Juan M. Adrian-Segarra, Sarah D. Grieder, Michael S. Kareta, Orly L. Wapinski, Cheen Euong Ang, Rui Li, Thomas C. Sudhof, Howard Y. Chang, Marius Wernig
NATURE CELL BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Alyssa Shepard, Sany Hoxha, Scott Troutman, David Harbaugh, Michael S. Kareta, Joseph L. Kissil
Summary: The Hippo pathway is tightly regulated by mechanical cues and YAP acts as a key transcriptional regulator. Through regulating miR-30a expression in Schwann cells, YAP influences cell proliferation and death decisions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Oncology
Ellen Voigt, Madeline Wallenburg, Hannah Wollenzien, Ethan Thompson, Kirtana Kumar, Joshua Feiner, Moira McNally, Hunter Friesen, Malini Mukherjee, Yohannes Afeworki, Michael S. Kareta
MOLECULAR CANCER RESEARCH
(2021)
Article
Oncology
Hannah Wollenzien, Yohannes Afeworki Tecleab, Robert Szczepaniak-Sloane, Anthony Restaino, Michael S. Kareta
Summary: Small cell lung cancer (SCLC) is a heterogeneous tumor with multiple populations of phenotypically different cells that contribute differently to tumor dynamics. Understanding the evolutionary dynamics of SCLC can shed light on key mechanisms such as cellular plasticity, heterogeneity, and chemoresistance. Cancer testis antigens (CTA) PAGE5 and GAGE2A have been identified as mediators of chemoresistance in human SCLC, and may be a promising avenue for targeted therapy.
MOLECULAR CANCER RESEARCH
(2023)
Article
Oncology
Joanne Doherty, Vinay Mandati, Maria A. Gonzalez Rodriguez, Scott Troutman, Alyssa Shepard, David Harbaugh, Rachel Brody, Douglas C. Miller, Michael S. Kareta, Joseph L. Kissil
Summary: Research found that NF2-deficient Schwann and schwannoma cells are sensitive to BET inhibition, primarily mediated by BRD4, which is overexpressed in human vestibular schwannomas. These results suggest that BRD4 regulates PI3K signaling and likely impedes NF2 schwannoma growth via this inhibition, implicating BET inhibition as a therapeutic option for NF2-deficient schwannomas.
NEURO-ONCOLOGY ADVANCES
(2022)
