Porphyrin modified trastuzumab improves efficacy of HER2 targeted photodynamic therapy of gastric cancer

Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla)

(2016) Yan Chen et al.   BIOCONJUGATE CHEMISTRY

Molecular targeted photoimmunotherapy for HER2-positive human gastric cancer in combination with chemotherapy results in improved treatment outcomes through different cytotoxic mechanisms

(2016) Kimihiro Ito et al.   BMC CANCER

In-depth structural characterization of Kadcyla® (ado-trastuzumab emtansine) and its biosimilar candidate

(2016) Liuxi Chen et al.   mAbs

Photoimmunotherapy Inhibits Tumor Recurrence After Surgical Resection on a Pancreatic Cancer Patient-Derived Orthotopic Xenograft (PDOX) Nude Mouse Model

(2015) Yukihiko Hiroshima et al.   ANNALS OF SURGICAL ONCOLOGY

Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

(2015) Patricia M. R. Pereira et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate

(2015) Julien Marcoux et al.   PROTEIN SCIENCE

Lysine conjugation properties in human IgGs studied by integrating high-resolution native mass spectrometry and bottom-up proteomics

(2015) Violette Gautier et al.   PROTEOMICS

Regioselective and Stoichiometrically Controlled Conjugation of Photodynamic Sensitizers to a HER2 Targeting Antibody Fragment

(2014) Francesca Bryden et al.   BIOCONJUGATE CHEMISTRY

Potent and specific antitumor effect of CEA-targeted photoimmunotherapy

(2014) Naoto Shirasu et al.   INTERNATIONAL JOURNAL OF CANCER

Preclinical Pharmacokinetic Considerations for the Development of Antibody Drug Conjugates

(2014) Amrita V. Kamath et al.   PHARMACEUTICAL RESEARCH

Photoimmunotherapy of Gastric Cancer Peritoneal Carcinomatosis in a Mouse Model

(2014) Kazuhide Sato et al.   PLoS One

Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?

(2014) Cecília Durães et al.   VIRCHOWS ARCHIV

Trastuzumab mediates antibody-dependent cell-mediated cytotoxicity and phagocytosis to the same extent in both adjuvant and metastatic HER2/neu breast cancer patients

(2013) Branka Petricevic et al.   Journal of Translational Medicine

Synthesis, bioanalysis and biodistribution of photosensitizer conjugates for photodynamic therapy

(2013) Tyler G St Denis et al.   Bioanalysis

Dye Sensitizers for Photodynamic Therapy

(2013) Alexandra Ormond et al.   Materials

Near-infrared Theranostic Photoimmunotherapy (PIT): Repeated Exposure of Light Enhances the Effect of Immunoconjugate

(2012) Makoto Mitsunaga et al.   BIOCONJUGATE CHEMISTRY

HER2 testing in gastric cancer: a practical approach

(2012) Josef Rüschoff et al.   MODERN PATHOLOGY

Trastuzumab: Updated Mechanisms of Action and Resistance in Breast Cancer

(2012) Thuy Vu et al.   Frontiers in Oncology

A chemically modified antibody mediates complete eradication of tumours by selective disruption of tumour blood vessels

(2011) A Palumbo et al.   BRITISH JOURNAL OF CANCER

Photodynamic therapy of cancer: An update

(2011) Patrizia Agostinis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Cancer cell–selective in vivo near infrared photoimmunotherapy targeting specific membrane molecules

(2011) Makoto Mitsunaga et al.   NATURE MEDICINE

Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial

(2010) Yung-Jue Bang et al.   LANCET

Targeting HER2-Positive Breast Cancer with Trastuzumab-DM1, an Antibody-Cytotoxic Drug Conjugate

(2008) G. D. Lewis Phillips et al.   CANCER RESEARCH