Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5

Down-regulation of TIMP2 by HIF-1α/miR-210/HIF-3α regulatory feedback circuit enhances cancer metastasis in hepatocellular carcinoma

(2016) Alan Ka-Lun Kai et al.   HEPATOLOGY

GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells

(2016) Anthony Leyme et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Recruitment of the Non-receptor Protein GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Is Sufficient for Activating Heterotrimeric G Protein Signaling

(2016) Kshitij Parag-Sharma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-101 Inhibiting Cell Proliferation, Migration and Invasion in Hepatocellular Carcinoma through Downregulating Girdin

(2016)   MOLECULES AND CELLS

Girdin/GIV is upregulated by cyclic tension, propagates mechanical signal transduction, and is required for the cellular proliferation and migration of MG-63 cells

(2015) Jiang-Tian Hu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Methylation-mediated silencing of Dlg5 facilitates bladder cancer metastasis

(2015) Zhihua Zhou et al.   EXPERIMENTAL CELL RESEARCH

GIV/Girdin Transmits Signals from Multiple Receptors by Triggering Trimeric G Protein Activation

(2015) Mikel Garcia-Marcos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrins activate trimeric G proteins via the nonreceptor protein GIV/Girdin

(2015) Anthony Leyme et al.   JOURNAL OF CELL BIOLOGY

Proteomic Characterization of Annexin l (ANX1) and Heat Shock Protein 27 (HSP27) as Biomarkers for Invasive Hepatocellular Carcinoma Cells

(2015) Ruo-Chiau Wang et al.   PLoS One

The Invadopodia Scaffold Protein Tks5 Is Required for the Growth of Human Breast Cancer Cells In Vitro and In Vivo

(2015) Barbara Blouw et al.   PLoS One

Loss of Dlg5 expression promotes the migration and invasion of prostate cancer cells via Girdin phosphorylation

(2014) L Tomiyama et al.   ONCOGENE

Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis

(2013) Tamilla Nechiporuk et al.   DEVELOPMENTAL BIOLOGY

Dlg5 interacts with the TGF-β receptor and promotes its degradation

(2013) Takuhito Sezaki et al.   FEBS LETTERS

Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment

(2013) Chi-Kuan Chen et al.   HEPATOLOGY

Src-dependent Tks5 phosphorylation regulates invadopodia-associated invasion in prostate cancer cells

(2013) Karen L. Burger et al.   PROSTATE

Overexpression of CXCL5 mediates neutrophil infiltration and indicates poor prognosis for hepatocellular carcinoma

(2012) Shao-Lai Zhou et al.   HEPATOLOGY

STAT3 Protein Up-regulates Gα-interacting Vesicle-associated Protein (GIV)/Girdin Expression, and GIV Enhances STAT3 Activation in a Positive Feedback Loop during Wound Healing and Tumor Invasion/Metastasis

(2012) Ying Dunkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell–cell fusion

(2012) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY

Role of Dlg5/lp-dlg, a Membrane-Associated Guanylate Kinase Family Protein, in Epithelial-Mesenchymal Transition in LLc-PK1 Renal Epithelial Cells

(2012) Takuhito Sezaki et al.   PLoS One

Twist1-Induced Invadopodia Formation Promotes Tumor Metastasis

(2011) Mark A. Eckert et al.   CANCER CELL

Management of hepatocellular carcinoma: An update

(2011) Jordi Bruix et al.   HEPATOLOGY

Phosphoinositide 3-kinase signaling pathway mediated by p110α regulates invadopodia formation

(2011) Hideki Yamaguchi et al.   JOURNAL OF CELL BIOLOGY

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Expression of GIV/Girdin, a metastasis-related protein, predicts patient survival in colon cancer

(2010) Mikel Garcia-Marcos et al.   FASEB JOURNAL

A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration

(2010) G. A. Smolen et al.   GENES & DEVELOPMENT

Chemokine receptor CXCR7 regulates the invasion,angiogenesis and tumor growth of human hepatocellular carcinoma cells

(2010) Ke Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

A Gαi–GIV Molecular Complex Binds Epidermal Growth Factor Receptor and Determines Whether Cells Migrate or Proliferate

(2010) Pradipta Ghosh et al.   MOLECULAR BIOLOGY OF THE CELL

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

Nck adaptor proteins link Tks5 to invadopodia actin regulation and ECM degradation

(2009) S. S. Stylli et al.   JOURNAL OF CELL SCIENCE

GIV is a nonreceptor GEF for G i with a unique motif that regulates Akt signaling

(2009) M. Garcia-Marcos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sequential signals toward podosome formation in NIH-src cells

(2008) Tsukasa Oikawa et al.   JOURNAL OF CELL BIOLOGY