Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 290, Issue 11, Pages 6697-6704Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.R114.613414
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Funding
- National Institutes of Health [R01GM108733, R01CA160911, R01099226, R01CA100768, R37DK17724]
- American Cancer Society [RSG-13-362-01-TBE]
- Burroughs Wellcome Foundation
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Activation of trimeric G proteins has been traditionally viewed as the exclusive job of G protein-coupled receptors (GPCRs). This view has been challenged by the discovery of non-receptor activators of trimericGproteins. Among them, GIV (a.k.a. Girdin) is the first for which a guanine nucleotide exchange factor (GEF) activity has been unequivocally associated with a well defined motif. Here we discuss how GIV assembles alternative signaling pathways by sensing cues from various classes of surface receptors and relaying them via G protein activation. We also describe the dysregulation of this mechanism in disease and how its targeting holds promise for novel therapeutics.
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