Low folate metabolic stress reprograms DNA methylation-activated sonic hedgehog signaling to mediate cancer stem cell-like signatures and invasive tumour stage-specific malignancy of human colorectal cancers

Folate deficient tumor microenvironment promotes epithelial-to-mesenchymal transition and cancer stem-like phenotypes

(2016) Yen-Hao Su et al.   Oncotarget

Red blood cell folate and plasma folate are not associated with risk of incident colorectal cancer in the Women's Health Initiative observational study

(2015) Marian L. Neuhouser et al.   INTERNATIONAL JOURNAL OF CANCER

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer

(2015) S-Q Liang et al.   Cell Death & Disease

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis

(2015) Rajneesh Pathania et al.   Nature Communications

Hedgehog Signaling in the Maintenance of Cancer Stem Cells

(2015) Catherine Cochrane et al.   Cancers

SOX2 regulates self-renewal and tumorigenicity of human melanoma-initiating cells

(2014) R Santini et al.   ONCOGENE

Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives

(2014) Caterina Fanali   WORLD JOURNAL OF GASTROENTEROLOGY

Epigenetic Regulation of SOX9 by the NF-κB Signaling Pathway in Pancreatic Cancer Stem Cells

(2013) Lei Sun et al.   STEM CELLS

Dietary Methyl Donor Depletion Protects Against Intestinal Tumorigenesis in ApcMin/+ Mice

(2012) K. Kadaveru et al.   Cancer Prevention Research

Folate deprivation enhances invasiveness of human colon cancer cells mediated by activation of sonic hedgehog signaling through promoter hypomethylation and cross action with transcription nuclear factor-kappa B pathway

(2012) Tz-Ping Wang et al.   CARCINOGENESIS

DNA methyltransferase 1 is essential for initiation of the colon cancers

(2012) Rena Morita et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Induced pluripotent stem cell-related genes influence biological behavior and 5-fluorouracil sensitivity of colorectal cancer cells

(2012) Zhong Shi et al.   Journal of Zhejiang University-SCIENCE B

Folate and DNA Methylation: A Review of Molecular Mechanisms and the Evidence for Folate's Role

(2012) Krista S. Crider et al.   Advances in Nutrition

Overexpression of Snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells

(2012) Fan Fan et al.   Cancer Medicine

Folate intake and risk of colorectal cancer and adenoma: modification by time

(2011) Jung Eun Lee et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer

(2011) Jens Neumann et al.   BMC CANCER

Altered Folate Availability Modifies the Molecular Environment of the Human Colorectum: Implications for Colorectal Carcinogenesis

(2011) P. Protiva et al.   Cancer Prevention Research

NANOG promoter methylation and expression correlation during normal and malignant human germ cell development

(2011) Daniel Nettersheim et al.   Epigenetics

A distinct DNA methylation profile associated with microsatellite and chromosomal stable sporadic colorectal cancers

(2011) Andrew Silver et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer cells in epithelial-to-mesenchymal transition and tumor-propagating–cancer stem cells: distinct, overlapping or same populations

(2011) S Floor et al.   ONCOGENE

Genetic Variability in the MTHFR Gene and Colorectal Cancer Risk Using the Colorectal Cancer Family Registry

(2010) A. J. Levine et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Loss of WNT-TCF addiction and enhancement of HH-GLI1 signalling define the metastatic transition of human colon carcinomas

(2010) Frédéric Varnat et al.   EMBO Molecular Medicine

Concentration of folate in colorectal tissue biopsies predicts prevalence of adenomatous polyps

(2010) A. Flood et al.   GUT

Cancer Statistics, 2009

(2009) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Epigenetic gene regulation in stem cells and correlation to cancer

(2009) Lesley A. Mathews et al.   DIFFERENTIATION

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

Distinct expression patterns of hedgehog ligands between cultured and primary colorectal cancers are associated with aberrant methylation of their promoters

(2009) Xiangsheng Fu et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL