Review
Biochemistry & Molecular Biology
Xiaojin Liu, Luodan Yang, Guangyao Li, Yingnan Jiang, Guoying Zhang, Jianya Ling
Summary: This article reviews the progress of research on Ganoderma lucidum polysaccharides (GLP) in nervous system diseases (NSDs), including structural characterization and biological functions, and summarizes the potential mechanisms of action, providing new perspectives for the study of GLP as a neuro-protective agent.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Yu Liu, Yongbing Long, Houcheng Liu, Yubin Lan, Teng Long, Run Kuang, Yifan Wang, Jing Zhao
Summary: This study explores the possibility of using hyperspectral imaging (HSI) to predict the polysaccharide content of Ganoderma lucidum in a nondestructive way during its growth. The study shows that the partial least square regression (PLSR) model, with the pretreatment method of Savitzky-Golay (SG) and standard normal variate (SNV), and the feature selection method of successive projections algorithm (SPA), performs well in predicting polysaccharide content. This study indicates that HSI can quickly and nondestructively detect the polysaccharide content of Ganoderma lucidum, providing guidance for the cultivation industry and improving economic benefits.
Article
Biochemistry & Molecular Biology
Miaoyu Li, Leilei Yu, Qixiao Zhai, Chuanqi Chu, Shunhe Wang, Jianxin Zhao, Hao Zhang, Fengwei Tian, Wei Chen
Summary: Clinical antibiotics can damage the intestinal barrier, while prebiotic Ganoderma lucidum extracts can protect the barrier and reduce inflammation. The combination of prebiotic G. lucidum polysaccharide (GLP) and ciprofloxacin reverses the negative effects of ciprofloxacin alone, improves the concentration of barrier proteins, and increases the abundance of probiotic bacteria. This combination therapy alleviates side effects and enhances the efficacy of antibiotic treatment against Salmonella infection.
Article
Chemistry, Applied
Qile Xia, Qin Zhao, Hua Zhu, Yan Cao, Kai Yang, Peilong Sun, Ming Cai
Summary: This study explored the structure characteristics of an oligosaccharide from Ganoderma lucidum and its regulatory functions on intestinal flora fermentation. The results showed that the oligosaccharide could not be easily degraded by digestion in the mouth, gastric and small intestine, and had good regulatory effects on intestinal flora. Therefore, it might be a potential prebiotic.
Article
Biochemistry & Molecular Biology
Wei-Lun Qiu, Hung-Chih Lo, Mei-Kuang Lu, Tung-Yi Lin
Summary: In this study, Ganoderma lucidum mycelia were harvested at different cultural stages to obtain GPS and GSPS. The results showed that GPS and GSPS isolated from mycelia cultured for 49 days exhibited the best anticancer effect and inhibited lung cancer growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Agriculture, Dairy & Animal Science
Juanqing Qin, Liwen Qin, Fu Zhang, Xiaoyu Fan, Huayun Jin, Zhijian Du, Yukang Guo, Weiwei Liu, Qinghua Liu
Summary: This study found that adding JCGLPP feed to Minxinan black rabbits can improve cecal fermentation parameters and intestinal flora structure and composition, but cannot improve slaughter performance.
ANIMAL BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Navid Omidifar, Wei-Hung Chiang, Vijayakameswara Rao Neralla, Khadije Yousefi, Mansoureh Shokripour
Summary: This study provides detailed characterization of Ganoderma lucidum methanolic extract (GLME) and demonstrates its antimicrobial and cytotoxic properties. The results indicate stronger anticancer activity against blood cancer cells compared to breast cancer cells, with lower toxicity on normal cells.
SCIENTIFIC REPORTS
(2023)
Review
Pharmacology & Pharmacy
Haoyuan Peng, Lei Zhong, Lin Cheng, Lu Chen, Rongsheng Tong, Jianyou Shi, Lan Bai
Summary: Ganoderma lucidum, also known as Lingzhi, is a widely-used herbal medicine with various pharmacological effects including antioxidant, antitumor, anti-aging, anti-liver fibrosis, and immunomodulation. Its main active components include triterpenoids, polysaccharides, sterols, peptides, and other bioactive ingredients. The triterpenoids and polysaccharides in G. lucidum have shown significant anti-liver fibrotic effects. Given the global increase in liver fibrosis cases, this review summarizes the role of G. lucidum extract in anti-liver fibrosis and its effects on fibrosis induced by different causes, providing insights for the development of G. lucidum extracts in anti-liver fibrosis treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Microbiology
Liyun Ye, Xiaofang He, Congbao Su, Haiying Feng, Guoliang Meng, Bingzhi Chen, Xiaoping Wu
Summary: This study analyzed the effect of mitochondria on Ganoderma lucidum morphology, yield, and main primary bioactive components using isonuclear alloplasmic strains, revealing differences in mycelial growth rate, basidiospore yield, and polysaccharide and triterpenoid content. Transcriptome data indicated involvement of differentially expressed genes in specific biological pathways.
Article
Biochemistry & Molecular Biology
Yuting Duan, Jiajing Huang, Mingjie Sun, Yuehang Jiang, Shihan Wang, Lei Wang, Nianjun Yu, Daiyin Peng, Yanyan Wang, Weidong Chen, Yue Zhang
Summary: The effects of Poria cocos polysaccharides (PCP) on the intestinal tract were investigated. PCP improved the physiological state of the mouse intestine, strengthened the intestinal physical barrier, regulated the immune barrier, and altered the microbial composition of the gut. PCP maintained intestinal barrier function by increasing the expression of Wnt/β-Catenin and Lrp5 proteins. These findings suggest that PCP could be used as a functional food to regulate intestinal mucosal function and enhance intestinal health.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Hui Fang, Xinxuan Li, Dongmei Lin, Lianfu Wang, Teng Yang, Baoxue Yang
Summary: Ganoderma lucidum polysaccharide peptide (GL-PP) and Ganoderma lucidum polysaccharide peptide 2 (GL-PP2), extracted from Ganoderma lucidum, have protective effects on proteinuria-induced renal dysfunction and damage. They inhibit inflammation and improve cellular viability. GL-PP2 has higher feasibility and productivity compared to GL-PP.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Changlin Zhen, Xunxun Wu, Jing Zhang, Dan Liu, Guoli Li, Yongbo Yan, Xiuzhen He, Jiawei Miao, Hongxia Song, Yifan Yan, Yonghui Zhang
Summary: The study found that Ganoderma lucidum polysaccharides (GLPs) can alleviate cardiac hypertrophy and fibrosis by inhibiting the expression of key genes, and attenuate pressure overload-induced pathological cardiac hypertrophy by activating PPAR?. This study provides important theoretical support for the potential use of GLPs in treating pathological myocardial hypertrophy and heart failure.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Applied
Yang Zhao, Qinyang Li, Minghui Wang, Yuhua Wang, Chunhong Piao, Hansong Yu, Junmei Liu, Zhuowei Li
Summary: In this study, Lactiplantibacillus plantarum ATCC14917 was used to ferment Ganoderma lucidum spore powder, and two polysaccharides were purified from unfermented (GLP) and fermented (FGLP) spore powder. The chemical structure and antioxidant activity of the polysaccharides were studied, and the effect of GLP and FGLP on the oxidative stress regulation pathway in HepG2 cells was explored.
Article
Food Science & Technology
Mengmeng Xu, Song Zhu, Lingling Wang, Zhiyi Wei, Liting Zhao, Guiyang Shi, Zhongyang Ding
Summary: This study found that low selenium levels do not affect the growth and mycelia morphology of Ganoderma lucidum, while high selenium levels have negative impacts, causing a significant decrease in biomass and various anomalies. The composition and quantity of bioactive metabolites in G. lucidum vary under different concentrations of selenite in liquid culture.
Article
Food Science & Technology
Lan Yang, Xincong Kang, Wenjing Dong, Lei Wang, Shifeng Liu, Xiaohong Zhong, Dongbo Liu
Summary: The study found that Ganoderma lucidum polysaccharide (GLP) can be utilized by human fecal microbiota, modify microbial community and metabolic function, and potentially serve as a novel prebiotic for human health benefits.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)