Splicing in immune cells—mechanistic insights and emerging topics

Rapid Genome-wide Recruitment of RNA Polymerase II Drives Transcription, Splicing, and Translation Events during T Cell Responses

(2017) Kathrin Davari et al.   Cell Reports

Functional impact of splice isoform diversity in individual cells

(2016) K. Yap et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Cajal body function in genome organization and transcriptome diversity

(2016) Iain A. Sawyer et al.   BIOESSAYS

Nuclear Speckle-related Protein 70 Binds to Serine/Arginine-rich Splicing Factors 1 and 2 via an Arginine/Serine-like Region and Counteracts Their Alternative Splicing Activity

(2016) Chang-Hyun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

(2016) Isabel Meininger et al.   Nature Communications

InSAC: A novel sub-nuclear body essential for Interleukin-6 and -10 RNA processing and stability

(2015) Sungwook Lee et al.   BMB Reports

MECHANISMS IN ENDOCRINOLOGY: Alternative splicing: the new frontier in diabetes research

(2015) Jonàs Juan-Mateu et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The RNA-binding protein HuR is essential for the B cell antibody response

(2015) Manuel D Diaz-Muñoz et al.   NATURE IMMUNOLOGY

TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells

(2015) Christopher A. Yarosh et al.   NUCLEIC ACIDS RESEARCH

Identification of a subnuclear body involved in sequence-specific cytokine RNA processing

(2015) Sungwook Lee et al.   Nature Communications

Regulation of Toll-like Receptor Signaling by the SF3a mRNA Splicing Complex

(2015) Brian P. O’Connor et al.   PLoS Genetics

PKC-Theta is a Novel SC35 Splicing Factor Regulator in Response to T Cell Activation

(2015) Robert Duncan McCuaig et al.   Frontiers in Immunology

IL-1β promotes Th17 differentiation by inducing alternative splicing of FOXP3

(2015) Reiner K. W. Mailer et al.   Scientific Reports

Identification of a chemical inhibitor for nuclear speckle formation: Implications for the function of nuclear speckles in regulation of alternative pre-mRNA splicing

(2014) Yutaro Kurogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pre-mRNA splicing is facilitated by an optimal RNA polymerase II elongation rate

(2014) Nova Fong et al.   GENES & DEVELOPMENT

Zfp318 Regulates IgD Expression by Abrogating Transcription Termination within theIghm/IghdLocus

(2014) Peter D. Pioli et al.   JOURNAL OF IMMUNOLOGY

U2AF1 mutations alter sequence specificity of pre-mRNA binding and splicing

(2014) T Okeyo-Owuor et al.   LEUKEMIA

Long Noncoding RNA NEAT1-Dependent SFPQ Relocation from Promoter Region to Paraspeckle Mediates IL8 Expression upon Immune Stimuli

(2014) Katsutoshi Imamura et al.   MOLECULAR CELL

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

A day in the life of the spliceosome

(2014) A. Gregory Matera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes

(2014) A. Enders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The human splicing code reveals new insights into the genetic determinants of disease

(2014) H. Y. Xiong et al.   SCIENCE

The Molecular Basis of Self-Avoidance

(2013) S. Lawrence Zipursky et al.   Annual Review of Neuroscience

Comparative Genomics RNAi Screen Identifies Eftud2 as a Novel Regulator of Innate Immunity

(2013) Lesly De Arras et al.   GENETICS

Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells

(2013) Alex K. Shalek et al.   NATURE

Hallmarks of alternative splicing in cancer

(2013) S Oltean et al.   ONCOGENE

Differential splicing across immune system lineages

(2013) A. Ergun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Finding the lost treasures in exome sequencing data

(2013) David C. Samuels et al.   TRENDS IN GENETICS

Limiting of the Innate Immune Response by SF3A-Dependent Control of MyD88 Alternative mRNA Splicing

(2013) Lesly De Arras et al.   PLoS Genetics

Commonly altered genomic regions in acute myeloid leukemia are enriched for somatic mutations involved in chromatin remodeling and splicing

(2012) A. Dolnik et al.   BLOOD

Transcript Dynamics of Proinflammatory Genes Revealed by Sequence Analysis of Subcellular RNA Fractions

(2012) Dev M. Bhatt et al.   CELL

Paraspeckle nuclear bodies—useful uselessness?

(2012) Shinichi Nakagawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Nuclear bodies: multifunctional companions of the genome

(2012) Miroslav Dundr   CURRENT OPINION IN CELL BIOLOGY

FoxO1 induces Ikaros splicing to promote immunoglobulin gene recombination

(2012) Alabbas Alkhatib et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Aberrant Expression of Splicing Factors in Newly Diagnosed Acute Myeloid Leukemia

(2012) Jing Liu et al.   ONKOLOGIE

CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing

(2012) Manish J. Butte et al.   PLoS One

Coaggregation of RNA-Binding Proteins in a Model of TDP-43 Proteinopathy with Selective RGG Motif Methylation and a Role for RRM1 Ubiquitination

(2012) Eric B. Dammer et al.   PLoS One

Alternative splicing networks regulated by signaling in human T cells

(2012) N. M. Martinez et al.   RNA

Clinical significance of SF3B1 mutations in myelodysplastic syndromes and myelodysplastic/myeloproliferative neoplasms

(2011) L. Malcovati et al.   BLOOD

RNA-sequence analysis of human B-cells

(2011) J. M. Toung et al.   GENOME RESEARCH

SF3B1 mutations in myelodysplastic syndromes: clinical associations and prognostic implications

(2011) F Damm et al.   LEUKEMIA

The t(1;9)(p34;q34) fusing ABL1 with SFPQ, a pre-mRNA processing gene, is recurrent in acute lymphoblastic leukemias

(2011) Francois P. Duhoux et al.   LEUKEMIA RESEARCH

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Frequent pathway mutations of splicing machinery in myelodysplasia

(2011) Kenichi Yoshida et al.   NATURE

Recurrent mutations in the U2AF1 splicing factor in myelodysplastic syndromes

(2011) Timothy A Graubert et al.   NATURE GENETICS

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

(2011) Víctor Quesada et al.   NATURE GENETICS

NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo

(2011) Young-Dae Kim et al.   NUCLEIC ACIDS RESEARCH

Biogenesis and function of nuclear bodies

(2011) Yuntao S. Mao et al.   TRENDS IN GENETICS

Evolution of SR protein and hnRNP splicing regulatory factors

(2011) Anke Busch et al.   Wiley Interdisciplinary Reviews-RNA

Depletion of hCINAP by RNA interference causes defects in Cajal body formation, histone transcription, and cell viability

(2010) Jinfang Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε

(2010) Rita Moreno et al.   NUCLEIC ACIDS RESEARCH

Nuclear Speckles

(2010) D. L. Spector et al.   Cold Spring Harbor Perspectives in Biology

Paraspeckles

(2010) A. H. Fox et al.   Cold Spring Harbor Perspectives in Biology

Absence of Leucine Zipper in the Natural FOXP3Δ2Δ7 Isoform Does Not Affect Dimerization but Abrogates Suppressive Capacity

(2009) Reiner K. W. Mailer et al.   PLoS One

The transcription factor c-Myb affects pre-mRNA splicing

(2008) Christophe Orvain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing

(2008) Qun Pan et al.   NATURE GENETICS

Regulation of CD45 Alternative Splicing by Heterogeneous Ribonucleoprotein, hnRNPLL

(2008) S. Oberdoerffer et al.   SCIENCE