Mechanisms of Beta Cell Dysfunction Associated With Viral Infection

Differential cell autonomous responses determine the outcome of coxsackievirus infections in murine pancreatic α and β cells

(2015) Laura Marroqui et al.   eLife

Viral Infection of Engrafted Human Islets Leads to Diabetes

(2014) Glen R. Gallagher et al.   DIABETES

Detection of a Low-Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes

(2014) Lars Krogvold et al.   DIABETES

Enterovirus infection is associated with an increased risk of childhood type 1 diabetes in Taiwan: a nationwide population-based cohort study

(2014) Hsiao-Chuan Lin et al.   DIABETOLOGIA

Coxsackievirus B3 induces crosstalk between autophagy and apoptosis to benefit its release after replicating in autophagosomes through a mechanism involving caspase cleavage of autophagy-related proteins

(2014) Le Xin et al.   INFECTION GENETICS AND EVOLUTION

Coxsackievirus can persist in murine pancreas by deletion of 5′ terminal genomic sequences

(2014) Steven Tracy et al.   JOURNAL OF MEDICAL VIROLOGY

Enterovirus 2Apro Targets MDA5 and MAVS in Infected Cells

(2014) Q. Feng et al.   JOURNAL OF VIROLOGY

Enterovirus 71 3C Inhibits Cytokine Expression through Cleavage of the TAK1/TAB1/TAB2/TAB3 Complex

(2014) X. Lei et al.   JOURNAL OF VIROLOGY

Enterovirus 68 3C Protease Cleaves TRIF To Attenuate Antiviral Responses Mediated by Toll-Like Receptor 3

(2014) Z. Xiang et al.   JOURNAL OF VIROLOGY

PTBP1 is required for glucose-stimulated cap-independent translation of insulin granule proteins and Coxsackieviruses in beta cells

(2014) Klaus-Peter Knoch et al.   Molecular Metabolism

Cleavage of sequestosome 1/p62 by an enteroviral protease results in disrupted selective autophagy and impaired NFKB signaling

(2013) Junyan Shi et al.   Autophagy

Virus Antibody Survey in Different European Populations Indicates Risk Association Between Coxsackievirus B1 and Type 1 Diabetes

(2013) S. Oikarinen et al.   DIABETES

Coxsackievirus B1 Is Associated With Induction of  -Cell Autoimmunity That Portends Type 1 Diabetes

(2013) O. H. Laitinen et al.   DIABETES

Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes

(2013) H.-S. Lee et al.   DIABETOLOGIA

Inhibition of Poliovirus-Induced Cleavage of Cellular Protein PCBP2 Reduces the Levels of Viral RNA Replication

(2013) A. J. Chase et al.   JOURNAL OF VIROLOGY

The nuclear protein Sam68 is redistributed to the cytoplasm and is involved in PI3K/Akt activation during EV71 infection

(2013) Hua Zhang et al.   VIRUS RESEARCH

Enterovirus 71 Protease 2Apro Targets MAVS to Inhibit Anti-Viral Type I Interferon Responses

(2013) Bei Wang et al.   PLoS Pathogens

Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa

(2012) M. Oikarinen et al.   DIABETES

Cytokine and Chemokine Production by Human Pancreatic Islets Upon Enterovirus Infection

(2012) B. M. Schulte et al.   DIABETES

Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction

(2012) P. Ylipaasto et al.   DIABETOLOGIA

Expression of the enteroviral capsid protein VP1 in the islet cells of patients with type 1 diabetes is associated with induction of protein kinase R and downregulation of Mcl-1

(2012) S. J. Richardson et al.   DIABETOLOGIA

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

(2012) Ken T. Coppieters et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Persistent Infection of Thymic Epithelial Cells with Coxsackievirus B4 Results in Decreased Expression of Type 2 Insulin-Like Growth Factor

(2012) H. Jaidane et al.   JOURNAL OF VIROLOGY

COPI Is Required for Enterovirus 71 Replication

(2012) Jianmin Wang et al.   PLoS One

Picornavirus Modification of a Host mRNA Decay Protein

(2012) J. M. Rozovics et al.   mBio

Immunohistochemical analysis of the relationship between islet cell proliferation and the production of the enteroviral capsid protein, VP1, in the islets of patients with recent-onset type 1 diabetes

(2011) A. Willcox et al.   DIABETOLOGIA

Modulation of innate immunity in human pancreatic islets infected with enterovirus in vitro

(2011) Oskar Skog et al.   JOURNAL OF MEDICAL VIROLOGY

Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance

(2011) Maikel L. Colli et al.   PLoS Pathogens

The Coxsackievirus B 3Cpro Protease Cleaves MAVS and TRIF to Attenuate Host Type I Interferon and Apoptotic Signaling

(2011) Amitava Mukherjee et al.   PLoS Pathogens

Evidence for Molecular Mimicry between Human T Cell Epitopes in Rotavirus and Pancreatic Islet Autoantigens

(2010) Margo C. Honeyman et al.   JOURNAL OF IMMUNOLOGY

Type 1 diabetes patients born to immigrants to Sweden increase their native diabetes risk and differ from Swedish patients in HLA types and islet autoantibodies

(2010) Ahmed J Delli et al.   PEDIATRIC DIABETES

Detection of Enterovirus RNA in Peripheral Blood Mononuclear Cells of Type 1 Diabetic Patients Beyond the Stage of Acute Infection

(2010) Barbara M. Schulte et al.   VIRAL IMMUNOLOGY

Enterovirus Infection, CXC Chemokine Ligand 10 (CXCL10), and CXCR3 Circuit: A Mechanism of Accelerated  -Cell Failure in Fulminant Type 1 Diabetes

(2009) S. Tanaka et al.   DIABETES

The prevalence of enteroviral capsid protein vp1 immunostaining in pancreatic islets in human type 1 diabetes

(2009) S. J. Richardson et al.   DIABETOLOGIA

Dynamin- and Lipid Raft-Dependent Entry of Decay-Accelerating Factor (DAF)-Binding and Non-DAF-Binding Coxsackieviruses into Nonpolarized Cells

(2009) K. P. Patel et al.   JOURNAL OF VIROLOGY

Incidence trends for childhood type 1 diabetes in Europe during 1989–2003 and predicted new cases 2005–20: a multicentre prospective registration study

(2009) Christopher C Patterson et al.   LANCET

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

(2009) Jeffrey C Barrett et al.   NATURE GENETICS

Coxsackievirus B4 infection of murine foetal thymus organ cultures

(2008) Fabienne Brilot et al.   JOURNAL OF MEDICAL VIROLOGY

Cleavage of eukaryotic initiation factor eIF5B by enterovirus 3C proteases

(2008) Sylvain de Breyne et al.   VIROLOGY