Interleukin 1 gene polymorphism and susceptibility to disease

Alarmins: Feel the Stress

(2017) Peleg Rider et al.   JOURNAL OF IMMUNOLOGY

MABp1 as a novel antibody treatment for advanced colorectal cancer: a randomised, double-blind, placebo-controlled, phase 3 study

(2017) Tamas Hickish et al.   LANCET ONCOLOGY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Canakinumab for first line steroid-free treatment in a child with systemic-onset juvenile idiopathic arthritis

(2017) G Horneff et al.   SCANDINAVIAN JOURNAL OF RHEUMATOLOGY

2016 updated EULAR evidence-based recommendations for the management of gout

(2016) P Richette et al.   ANNALS OF THE RHEUMATIC DISEASES

Adult-onset Still's disease: Advances in the treatment

(2016) Santos Castañeda et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Host and Environmental Factors Influencing Individual Human Cytokine Responses

(2016) Rob ter Horst et al.   CELL

Interleukins (from IL-1 to IL-38), interferons, transforming growth factor β, and TNF-α: Receptors, functions, and roles in diseases

(2016) Mübeccel Akdis et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hepatitis-related hepatocellular carcinoma: Insights into cytokine gene polymorphisms

(2016) Mahmoud Fathy Dondeti et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Erratum: Corrigendum: IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

(2016) Idan Cohen et al.   Scientific Reports

IL-1β/IL-6/CRP and IL-18/ferritin: Distinct Inflammatory Programs in Infections

(2016) Jeroen Slaats et al.   PLoS Pathogens

Expression of IL-1α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer

(2016) Zhiwang Song et al.   MEDICAL SCIENCE MONITOR

IL-1 Inhibition in Systemic Juvenile Idiopathic Arthritis

(2016) Gabriella Giancane et al.   Frontiers in Pharmacology

Persistent HPV16/18 infection in Indian women with the A-allele (rs6457617) of HLA-DQB1 and T-allele (rs16944) of IL-1β −511 is associated with development of cervical carcinoma

(2015) Sankhadeep Dutta et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Gcn5 Modulates the Cellular Response to Oxidative Stress and Histone Deacetylase Inhibition

(2015) Ann-Christin Gaupel et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cutting Edge: A Natural Antisense Transcript, AS-IL1α, Controls Inducible Transcription of the Proinflammatory Cytokine IL-1α

(2015) Jennie Chan et al.   JOURNAL OF IMMUNOLOGY

Human caspase-4 and caspase-5 regulate the one-step non-canonical inflammasome activation in monocytes

(2015) Elena Viganò et al.   Nature Communications

IL-1α is a DNA damage sensor linking genotoxic stress signaling to sterile inflammation and innate immunity

(2015) Cohen Idan et al.   Scientific Reports

The interleukin-1 receptor antagonist anakinra improves endothelial dysfunction in streptozotocin-induced diabetic rats

(2014) Susana Vallejo et al.   Cardiovascular Diabetology

The interleukin-1 receptor antagonist anakinra improves first-phase insulin secretion and insulinogenic index in subjects with impaired glucose tolerance

(2014) P. C. M. van Poppel et al.   DIABETES OBESITY & METABOLISM

The chicken IL-1 family: evolution in the context of the studied vertebrate lineage

(2014) Mark S. Gibson et al.   IMMUNOGENETICS

Interleukin 1β and Interleukin 1 Receptor Antagonist Gene Polymorphisms and Cervical Cancer

(2014) Shimu Wu et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Meta-Analysis of Associations of IL1 Receptor Antagonist and Estrogen Receptor Gene Polymorphisms with Systemic Lupus Erythematosus Susceptibility

(2014) Li Cai et al.   PLoS One

Endogenous IL-1α is a chromatin-associated protein in mouse macrophages

(2013) Céline Lamacchia et al.   CYTOKINE

Association between IL-1RN gene polymorphisms and susceptibility to ankylosing spondylitis: a large Human Genome Epidemiology review and meta-analysis

(2013) G.X. Jin et al.   GENETICS AND MOLECULAR RESEARCH

The Interleukin-1 Family: Back to the Future

(2013) Cecilia Garlanda et al.   IMMUNITY

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

(2013) Arnaud François et al.   Journal of Neuroinflammation

RIP1-driven autoinflammation targets IL-1α independently of inflammasomes and RIP3

(2013) John R. Lukens et al.   NATURE

Sirtuins in stress response: guardians of the genome

(2013) L Bosch-Presegué et al.   ONCOGENE

The Interplay of the Interleukin 1 System in Pregnancy and Labor

(2013) Yujing Jan Heng et al.   Reproductive Sciences

Interleukin-1α

(2013) Peleg Rider et al.   SEMINARS IN IMMUNOLOGY

Inhibition of IL-1 Signaling by Antisense Oligonucleotide-mediated Exon Skipping of IL-1 Receptor Accessory Protein (IL-1RAcP)

(2013) A Seda Yılmaz-Eliş et al.   Molecular Therapy-Nucleic Acids

Different Members of the IL-1 Family Come Out in Different Ways: DAMPs vs. Cytokines?

(2013) Sonia Carta et al.   Frontiers in Immunology

Canakinumab for acute gouty arthritis in patients with limited treatment options: results from two randomised, multicentre, active-controlled, double-blind trials and their initial extensions

(2012) Naomi Schlesinger et al.   ANNALS OF THE RHEUMATIC DISEASES

Single nucleotide polymorphisms (SNPs) of pro-inflammatory/anti-inflammatory and thrombotic/fibrinolytic genes in patients with acute ischemic stroke in relation to TOAST subtype

(2012) Antonino Tuttolomondo et al.   CYTOKINE

Effect of anti-IL-1β antibody (canakinumab) on insulin secretion rates in impaired glucose tolerance or type 2 diabetes: results of a randomized, placebo-controlled trial

(2012) A. Rissanen et al.   DIABETES OBESITY & METABOLISM

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1

(2012) X. Luo et al.   GENES & DEVELOPMENT

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Alarmins: awaiting a clinical response

(2012) James K. Chan et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: FAS (CD95) Mediates Noncanonical IL-1  and IL-18 Maturation via Caspase-8 in an RIP3-Independent Manner

(2012) L. Bossaller et al.   JOURNAL OF IMMUNOLOGY

Placental Secretion of Interleukin-1 and Interleukin-1 Receptor Antagonist in Preeclampsia: Effect of Magnesium Sulfate

(2012) Alaa Amash et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Beneficial Effect of Interleukin 1 Inhibition with Anakinra in Adult-onset Still's Disease. An Open, Randomized, Multicenter Study

(2012) D. NORDSTROM et al.   JOURNAL OF RHEUMATOLOGY

IL-1RN VNTR polymorphism and genetic susceptibility to cervical cancer in Portugal

(2012) Hugo Sousa et al.   MOLECULAR BIOLOGY REPORTS

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis

(2012) Nicolino Ruperto et al.   NEW ENGLAND JOURNAL OF MEDICINE

The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells

(2012) Peleg Rider et al.   Frontiers in Immunology

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Immunology in clinic review series; focus on autoinflammatory diseases: role of inflammasomes in autoinflammatory syndromes

(2011) V. U. Ozkurede et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Understanding the mechanism of IL-1β secretion

(2011) Gloria Lopez-Castejon et al.   CYTOKINE & GROWTH FACTOR REVIEWS

IL-1  and IL-1  Recruit Different Myeloid Cells and Promote Different Stages of Sterile Inflammation

(2011) P. Rider et al.   JOURNAL OF IMMUNOLOGY

Association between circulating interleukin-1 beta (IL-1β) levels and IL-1β C–511T polymorphism with cervical cancer risk in Egyptian women

(2011) Magdy A. Al-Tahhan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

(2011) Inna S. Afonina et al.   MOLECULAR CELL

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice

(2011) Jae-Young Um et al.   PLoS One

Lung fibrosis induced by crystalline silica particles is uncoupled from lung inflammation in NMRI mice

(2011) Virginie Rabolli et al.   TOXICOLOGY LETTERS

Role of IL-1β in type 2 diabetes

(2011) Charles A Dinarello et al.   Current Opinion in Endocrinology Diabetes and Obesity

Interleukin 1 receptor antagonist polymorphisms are associated with the risk of developing acute coronary syndrome in Mexicans

(2010) José Manuel Fragoso et al.   IMMUNOLOGY LETTERS

DAMPening Inflammation by Modulating TLR Signalling

(2010) A. M. Piccinini et al.   MEDIATORS OF INFLAMMATION

Differential release of chromatin-bound IL-1  discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation

(2010) I. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of posttranslational modifications in the assembly of stress granules

(2010) Takbum Ohn et al.   Wiley Interdisciplinary Reviews-RNA

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Increased Serum IL-1β Level in Alzheimer’s Disease and Mild Cognitive Impairment

(2009) Orestes Vicente Forlenza et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes

(2009) C. M. Larsen et al.   DIABETES CARE

Nuclear retention of IL-1α by necrotic cells: A mechanism to dampen sterile inflammation

(2009) Nadia M. Luheshi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

(2009) Luke A. J. O'Neill   IMMUNOLOGICAL REVIEWS

Circulating IL-1β levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women

(2009) Nianfeng Qian et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

An Autoinflammatory Disease with Deficiency of the Interleukin-1–Receptor Antagonist

(2009) Ivona Aksentijevich et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell surface-bound IL-1  is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network

(2009) A. V. Orjalo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor

(2008) Yujing J. Heng et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

ORIGINAL ARTICLE: Maternal and Neonatal Interleukin-1 Receptor Antagonist Genotype and Pregnancy Outcome in a Population with a High Rate of Pre-term Birth

(2008) José Humberto Belmino Chaves et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis

(2008) Gulnara Mamyrova et al.   ARTHRITIS AND RHEUMATISM

Haplotypes of the interleukin-1 receptor antagonist gene, interleukin-1 receptor antagonist mRNA levels and the risk of myocardial infarction

(2008) Rick van Minkelen et al.   ATHEROSCLEROSIS

Genetic variants of interleukin-1RN and interleukin-1β genes and risk of cervical cancer

(2008) H Singh et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Differential requirement for the activation of the inflammasome for processing and release of IL-1  in monocytes and macrophages

(2008) M. G. Netea et al.   BLOOD

Cytokine and cytokine receptor gene polymorphisms and their functionality

(2008) Andrew J.P. Smith et al.   CYTOKINE & GROWTH FACTOR REVIEWS