Contribution of new technologies to characterization and prediction of adverse effects

Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations

(2015) Floris A. Groothuis et al.   TOXICOLOGY

Systems Toxicology: From Basic Research to Risk Assessment

(2014) Shana J. Sturla et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Mode of action human relevance (species concordance) framework: Evolution of the Bradford Hill considerations and comparative analysis of weight of evidence

(2014) M. E. Bette Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Liver tumor formation in female rat induced by fluopyram is mediated by CAR/PXR nuclear receptor activation

(2014) H. Tinwell et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Thyroid tumor formation in the male mouse induced by fluopyram is mediated by activation of hepatic CAR/PXR nuclear receptors

(2014) D. Rouquié et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

The sensitivity of metabolomics versus classical regulatory toxicology from a NOAEL perspective

(2014) B. van Ravenzwaay et al.   TOXICOLOGY LETTERS

The use of biomarkers of toxicity for integrating in vitro hazard estimates into risk assessment for humans

(2014) Bas Blaauboer   ALTEX-Alternatives to Animal Experimentation

Lessons learned, challenges, and opportunities: The U.S. Endocrine Disruptor Screening Program

(2014)   ALTEX-Alternatives to Animal Experimentation

Adverse outcome pathways: hype or hope?

(2013) Mathieu Vinken et al.   ARCHIVES OF TOXICOLOGY

A review of the mode of toxicity and relevance to humans of the triketone herbicide 2-(4-methylsulfonyl-2-nitrobenzoyl)-1,3-cyclohexanedione

(2013) Richard W. Lewis et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

(2013) R. A. Budinsky et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action framework analysis for receptor-mediated toxicity: The peroxisome proliferator-activated receptor alpha (PPARα) as a case study

(2013) J. Christopher Corton et al.   CRITICAL REVIEWS IN TOXICOLOGY

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

(2013) Clifford R. Elcombe et al.   CRITICAL REVIEWS IN TOXICOLOGY

Improving the Human Hazard Characterization of Chemicals: A Tox21 Update

(2013) Raymond R. Tice et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

New developments in the evolution and application of the WHO/IPCS framework on mode of action/species concordance analysis

(2013) M. E. Meek et al.   JOURNAL OF APPLIED TOXICOLOGY

Incorporating New Technologies Into Toxicity Testing and Risk Assessment: Moving From 21st Century Vision to a Data-Driven Framework

(2013) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals

(2013) AlberTinka J. Murk et al.   TOXICOLOGY IN VITRO

Evaluation of simple in vitro to in vivo extrapolation approaches for environmental compounds

(2013) Miyoung Yoon et al.   TOXICOLOGY IN VITRO

Update on EPA’s ToxCast Program: Providing High Throughput Decision Support Tools for Chemical Risk Management

(2012) Robert Kavlock et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Quantifying Processes Determining the Free Concentration of Phenanthrene in Basal Cytotoxicity Assays

(2012) Nynke I. Kramer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Using in Vitro High Throughput Screening Assays to Identify Potential Endocrine-Disrupting Chemicals

(2012) Daniel M. Rotroff et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

Metabolomics: A tool for early detection of toxicological effects and an opportunity for biology based grouping of chemicals—From QSAR to QBAR

(2012) B. van Ravenzwaay et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Integrating pathway-based transcriptomic data into quantitative chemical risk assessment: A five chemical case study

(2012) Russell S. Thomas et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

A testing strategy for the identification of mammalian, systemic endocrine disruptors with particular focus on steroids

(2012) Susanne N. Kolle et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials

(2012) Caroline Bauch et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Identification and Characterization of Adverse Effects in 21st Century Toxicology

(2012) Douglas A. Keller et al.   TOXICOLOGICAL SCIENCES

Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

(2012) Michael B. Black et al.   TOXICOLOGICAL SCIENCES

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

(2011) Paul Jennings et al.   ARCHIVES OF TOXICOLOGY

An untargeted multi-technique metabolomics approach to studying intracellular metabolites of HepG2 cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin

(2011) Ainhoa Ruiz-Aracama et al.   BMC GENOMICS

Integrating transcriptomics and metabonomics to unravel modes-of-action of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in HepG2 cells

(2011) Danyel Jennen et al.   BMC Systems Biology

Consideration of dosimetry in evaluation of ToxCast™ data

(2011) Lesa L. Aylward et al.   JOURNAL OF APPLIED TOXICOLOGY

A Molecular and Phenotypic Integrative Approach to Identify a No-Effect Dose Level for Antiandrogen-Induced Testicular Toxicity

(2011) Sophie Ludwig et al.   TOXICOLOGICAL SCIENCES

Metabolic profiling using HPLC allows classification of drugs according to their mechanisms of action in HL-1 cardiomyocytes

(2011) Alexander Strigun et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Identifying developmental toxicity pathways for a subset of ToxCast chemicals using human embryonic stem cells and metabolomics

(2011) N.C. Kleinstreuer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Linking energy metabolism to dysfunctions in mitochondrial respiration – A metabolomics in vitro approach

(2011) G.U. Balcke et al.   TOXICOLOGY LETTERS

From 3D cell culture to organs-on-chips

(2011) Dongeun Huh et al.   TRENDS IN CELL BIOLOGY

Development of a Partition-Controlled Dosing System for Cell Assays

(2010) Nynke I. Kramer et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Biokinetic Modeling andin Vitro–in VivoExtrapolations

(2010) Bas J. Blaauboer   JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS

Organotypic 3D cell culture models: using the rotating wall vessel to study host–pathogen interactions

(2010) Jennifer Barrila et al.   NATURE REVIEWS MICROBIOLOGY

Performance of Novel Kidney Biomarkers in Preclinical Toxicity Studies

(2010) Dana Hoffmann et al.   TOXICOLOGICAL SCIENCES

The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in Rat and Man

(2010) Jochem Louisse et al.   TOXICOLOGICAL SCIENCES

Keratinocyte Gene Expression Profiles Discriminate Sensitizing and Irritating Compounds

(2010) Rob J. Vandebriel et al.   TOXICOLOGICAL SCIENCES

The Vision of Toxicity Testing in the 21st Century: Moving from Discussion to Action

(2010) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Application of Transcriptional Benchmark Dose Values in Quantitative Cancer and Noncancer Risk Assessment

(2010) Russell S. Thomas et al.   TOXICOLOGICAL SCIENCES

Predicting human developmental toxicity of pharmaceuticals using human embryonic stem cells and metabolomics

(2010) Paul R. West et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cross-study and cross-omics comparisons of three nephrotoxic compounds reveal mechanistic insights and new candidate biomarkers

(2010) Katja A. Matheis et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

1H NMR-based metabolic profiling of naproxen-induced toxicity in rats

(2010) Jeeyoun Jung et al.   TOXICOLOGY LETTERS

In Vitro Screening of Environmental Chemicals for Targeted Testing Prioritization: The ToxCast Project

(2009) Richard S. Judson et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Acetaminophen dosing of humans results in blood transcriptome and metabolome changes consistent with impaired oxidative phosphorylation

(2009) Rick D. Fannin et al.   HEPATOLOGY

Early gene expression changes during embryonic stem cell differentiation into cardiomyocytes and their modulation by monobutyl phthalate

(2009) Dorien A.M. van Dartel et al.   REPRODUCTIVE TOXICOLOGY

Toxicity Testing in the 21st Century: Using the New Toxicity Testing Paradigm to Create a Taxonomy of Adverse Effects

(2009) Kim Boekelheide et al.   TOXICOLOGICAL SCIENCES

Toxicity Testing in the 21st Century: A View from the Chemical Industry

(2009) James S. Bus et al.   TOXICOLOGICAL SCIENCES

Standard and Molecular NOAELs for Rat Testicular Toxicity Induced by Flutamide

(2009) David Rouquié et al.   TOXICOLOGICAL SCIENCES

Transcriptional Response of Rat Frontal Cortex following Acute In Vivo Exposure to the Pyrethroid Insecticides Permethrin and Deltamethrin

(2008) Joshua A Harrill et al.   BMC GENOMICS

Genomic Signatures and Dose-Dependent Transitions in Nasal Epithelial Responses to Inhaled Formaldehyde in the Rat

(2008) Melvin E. Andersen et al.   TOXICOLOGICAL SCIENCES

Prediction of a carcinogenic potential of rat hepatocarcinogens using toxicogenomics analysis of short-term in vivo studies

(2007) Heidrun Ellinger-Ziegelbauer et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A novel in vitro metabolomics approach for neurotoxicity testing, proof of principle for methyl mercury chloride and caffeine

(2007) Erwin van Vliet et al.   NEUROTOXICOLOGY

Paraquat toxicity in a mouse embryonic stem cell model

(2007) Venu Perla et al.   TOXICOLOGY IN VITRO

First steps in establishing a developmental toxicity test method based on human embryonic stem cells

(2007) Sarah Adler et al.   TOXICOLOGY IN VITRO