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Title
The ubiquity of pleiotropy in human disease
Authors
Keywords
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Journal
HUMAN GENETICS
Volume 137, Issue 1, Pages 39-44
Publisher
Springer Nature
Online
2017-11-21
DOI
10.1007/s00439-017-1854-z
References
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Note: Only part of the references are listed.- Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights
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- A plethora of pleiotropy across complex traits
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- Detection and interpretation of shared genetic influences on 42 human traits
- (2016) Joseph K Pickrell et al. NATURE GENETICS
- An atlas of genetic correlations across human diseases and traits
- (2015) Brendan Bulik-Sullivan et al. NATURE GENETICS
- Implications of pleiotropy: challenges and opportunities for mining Big Data in biomedicine
- (2015) Can Yang et al. Frontiers in Genetics
- Disease Risk Factors Identified Through Shared Genetic Architecture and Electronic Medical Records
- (2014) L. Li et al. Science Translational Medicine
- GPA: A Statistical Approach to Prioritizing GWAS Results by Integrating Pleiotropy and Annotation
- (2014) Dongjun Chung et al. PLoS Genetics
- Improving genetic risk prediction by leveraging pleiotropy
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- Pleiotropy in complex traits: challenges and strategies
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- The NHGRI GWAS Catalog, a curated resource of SNP-trait associations
- (2013) Danielle Welter et al. NUCLEIC ACIDS RESEARCH
- Phenome-Wide Association Study (PheWAS) for Detection of Pleiotropy within the Population Architecture using Genomics and Epidemiology (PAGE) Network
- (2013) Sarah A. Pendergrass et al. PLoS Genetics
- Five Years of GWAS Discovery
- (2012) Peter M. Visscher et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Estimation of pleiotropy between complex diseases using single-nucleotide polymorphism-derived genomic relationships and restricted maximum likelihood
- (2012) S.H. Lee et al. BIOINFORMATICS
- On the Pleiotropic Structure of the Genotype-Phenotype Map and the Evolvability of Complex Organisms
- (2012) W. G. Hill et al. GENETICS
- Abundant Pleiotropy in Human Complex Diseases and Traits
- (2011) Shanya Sivakumaran et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms
- (2011) Günter P. Wagner et al. NATURE REVIEWS GENETICS
- One Hundred Years of Pleiotropy: A Retrospective
- (2010) F. W. Stearns GENETICS
- Genomic patterns of pleiotropy and the evolution of complexity
- (2010) Z. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Shadows of complexity: what biological networks reveal about epistasis and pleiotropy
- (2009) Anna L. Tyler et al. BIOESSAYS
- Pleiotropic scaling of gene effects and the ‘cost of complexity’
- (2008) Günter P. Wagner et al. NATURE
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