Aberrant cognitive phenotypes and altered hippocampal BDNF expression related to epigenetic modifications in mice lacking the post-synaptic scaffolding protein SHANK1: Implications for autism spectrum disorder

Advancing the understanding of autism disease mechanisms through genetics

(2016) Luis de la Torre-Ubieta et al.   NATURE MEDICINE

Impaired cognitive discrimination and discoordination of coupled theta–gamma oscillations in Fmr1 knockout mice

(2016) Basma Radwan et al.   NEUROBIOLOGY OF DISEASE

Age-Dependent Specific Changes in Area CA2 of the Hippocampus and Social Memory Deficit in a Mouse Model of the 22q11.2 Deletion Syndrome

(2016) Rebecca A. Piskorowski et al.   NEURON

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

(2016) Jing Li et al.   Science Signaling

De novo genic mutations among a Chinese autism spectrum disorder cohort

(2016) Tianyun Wang et al.   Nature Communications

Reduction in parvalbumin expression not loss of the parvalbumin-expressing GABA interneuron subpopulation in genetic parvalbumin and shank mouse models of autism

(2016) Federica Filice et al.   Molecular Brain

Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome

(2016) Jing Li et al.   Science Signaling

Early communication deficits in theShank1knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

(2015) A. Özge Sungur et al.   Autism Research

Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation

(2015) Hani Harb et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Shank synaptic scaffold proteins: keys to understanding the pathogenesis of autism and other synaptic disorders

(2015) Carlo Sala et al.   JOURNAL OF NEUROCHEMISTRY

A coding-independent function of an alternative Ube3a transcript during neuronal development

(2015) Jeremy Valluy et al.   NATURE NEUROSCIENCE

Prospects for the development of epigenetic drugs for CNS conditions

(2015) Moshe Szyf   NATURE REVIEWS DRUG DISCOVERY

From the genetic architecture to synaptic plasticity in autism spectrum disorder

(2015) Thomas Bourgeron   NATURE REVIEWS NEUROSCIENCE

Lack of parvalbumin in mice leads to behavioral deficits relevant to all human autism core symptoms and related neural morphofunctional abnormalities

(2015) M Wöhr et al.   Translational Psychiatry

Repetitive behaviors in the Shank1 knockout mouse model for autism spectrum disorder: Developmental aspects and effects of social context

(2014) A. Özge Sungur et al.   JOURNAL OF NEUROSCIENCE METHODS

Increased BDNF expression in fetal brain in the valproic acid model of autism

(2014) Luis E.F. Almeida et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity

(2014) J Ellegood et al.   MOLECULAR PSYCHIATRY

Cytokine aberrations in autism spectrum disorder: a systematic review and meta-analysis

(2014) A Masi et al.   MOLECULAR PSYCHIATRY

The hippocampal CA2 region is essential for social memory

(2014) Frederick L. Hitti et al.   NATURE

Histone core modifications regulating nucleosome structure and dynamics

(2014) Peter Tessarz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Ultrasonic vocalizations in Shank mouse models for autism spectrum disorders: Detailed spectrographic analyses and developmental profiles

(2014) Markus Wöhr   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

A Non-Canonical Initiation Site Is Required for Efficient Translation of the Dendritically Localized Shank1 mRNA

(2014) Katrin Studtmann et al.   PLoS One

Reciprocal signaling between translational control pathways and synaptic proteins in autism spectrum disorders

(2014) E. Santini et al.   Science Signaling

Abnormalities in the zinc-metalloprotease-BDNF axis may contribute to megalencephaly and cortical hyperconnectivity in young autism spectrum disorder patients

(2014) Jae-Young Koh et al.   Molecular Brain

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments

(2014) Claire S. Leblond et al.   PLoS Genetics

A cytokine network involving brain-borne IL-1β, IL-1ra, IL-18, IL-6, and TNFα operates during long-term potentiation and learning

(2013) Adriana del Rey et al.   BRAIN BEHAVIOR AND IMMUNITY

A role for synaptic zinc in ProSAP/Shank PSD scaffold malformation in autism spectrum disorders

(2013) Andreas M. Grabrucker   Developmental Neurobiology

The emerging role ofSHANKgenes in neuropsychiatric disorders

(2013) Audrey Guilmatre et al.   Developmental Neurobiology

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Neurotrophins play differential roles in short and long-term recognition memory

(2013) Charlotte K. Callaghan et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Modeling Autism by SHANK Gene Mutations in Mice

(2013) Yong-hui Jiang et al.   NEURON

Shank mutant mice as an animal model of autism

(2013) J. Yoo et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Alternative polyadenylation and differential expression of Shank mRNAs in the synaptic neuropil

(2013) I. Epstein et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Examining and interpreting the female protective effect against autistic behavior

(2013) E. B. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neonatal levels of neurotrophic factors and risk of autism spectrum disorders

(2012) M. W. Abdallah et al.   ACTA PSYCHIATRICA SCANDINAVICA

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Functional Consequences of Mutations in Postsynaptic Scaffolding Proteins and Relevance to Psychiatric Disorders

(2012) Jonathan T. Ting et al.   Annual Review of Neuroscience

Developmental delays and reduced pup ultrasonic vocalizations but normal sociability in mice lacking the postsynaptic cell adhesion protein neuroligin2

(2012) Markus Wöhr et al.   BEHAVIOURAL BRAIN RESEARCH

SHANK3 as an autism spectrum disorder-associated gene

(2012) Shigeo Uchino et al.   BRAIN & DEVELOPMENT

Reduced Excitatory Neurotransmission and Mild Autism-Relevant Phenotypes in Adolescent Shank3 Null Mutant Mice

(2012) M. Yang et al.   JOURNAL OF NEUROSCIENCE

Age-dependent deficits in fear learning in heterozygous BDNF knock-out mice

(2012) T. Endres et al.   LEARNING & MEMORY

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

Neurotrophin regulation of neural circuit development and function

(2012) Hyungju Park et al.   NATURE REVIEWS NEUROSCIENCE

Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders

(2012) Claire S. Leblond et al.   PLoS Genetics

Brain-Derived Neurotrophic Factor: A Dynamic Gatekeeper of Neural Plasticity

(2012) Kiriana Cowansage et al.   Current Molecular Pharmacology

A promoter variant of SHANK1 affects auditory working memory in schizophrenia patients and in subjects clinically at risk for psychosis

(2011) Leonhard Lennertz et al.   EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE

Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology

(2011) Simone Berkel et al.   HUMAN MOLECULAR GENETICS

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Working memory deficits, increased anxiety-like traits, and seizure susceptibility in BDNF overexpressing mice

(2011) F. Papaleo et al.   LEARNING & MEMORY

Epigenetic regulation of the BDNF gene: implications for psychiatric disorders

(2011) F Boulle et al.   MOLECULAR PSYCHIATRY

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior

(2011) Markus Wöhr et al.   PLoS One

Correlations of recognition memory performance with expression and methylation of brain-derived neurotrophic factor in rats

(2010) Pablo C Muñoz et al.   BIOLOGICAL RESEARCH

Sociability and motor functions in Shank1 mutant mice

(2010) Jill L. Silverman et al.   BRAIN RESEARCH

Increased BDNF levels and NTRK2 gene association suggest a disruption of BDNF/TrkB signaling in autism

(2010) C. T. Correia et al.   GENES BRAIN AND BEHAVIOR

The role of neurotrophic factors in autism

(2010) T Nickl-Jockschat et al.   MOLECULAR PSYCHIATRY

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

(2010) Simone Berkel et al.   NATURE GENETICS

BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse

(2010) Verna Louhivuori et al.   NEUROBIOLOGY OF DISEASE

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Neuroanatomy of autism

(2008) David G. Amaral et al.   TRENDS IN NEUROSCIENCES