IL6-mediated inflammatory loop reprograms normal to epithelial-mesenchymal transition+ metastatic cancer stem cells in preneoplastic liver of transforming growth factor beta-deficient β2-spectrin+/− mice

IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden

(2015) M. van der Zee et al.   CANCER RESEARCH

Adaptive Upregulation of EGFR Limits Attenuation of Tumor Growth by Neutralizing IL6 Antibodies, with Implications for Combined Therapy in Ovarian Cancer

(2015) C. S. Milagre et al.   CANCER RESEARCH

Activation of IL6/IGFIR Confers Poor Prognosis of HBV-Related Hepatocellular Carcinoma through Induction of OCT4/NANOG Expression

(2015) T.-S. Chang et al.   CLINICAL CANCER RESEARCH

Signal transducer and activator of transcription 3-mediated CD133 up-regulation contributes to promotion of hepatocellular carcinoma

(2015) Cheolhee Won et al.   HEPATOLOGY

βII-Spectrin (SPTBN1) suppresses progression of hepatocellular carcinoma and Wnt signaling by regulation of Wnt inhibitor kallistatin

(2015) Xiuling Zhi et al.   HEPATOLOGY

Autophagy Supports Breast Cancer Stem Cell Maintenance by Regulating IL6 Secretion

(2015) Paola Maycotte et al.   MOLECULAR CANCER RESEARCH

Lack of gp130 expression in hepatocytes attenuates tumor progression in the DEN model

(2015) M Hatting et al.   Cell Death & Disease

Suppression of Glypican 3 Inhibits Growth of Hepatocellular Carcinoma Cells through Up-Regulation of TGF-β2

(2015) Chris K. Sun et al.   NEOPLASIA

Metabolic Activation of Intrahepatic CD8+ T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes

(2014) Monika Julia Wolf et al.   CANCER CELL

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

IL-30 (IL27p28) attenuates liver fibrosis through inducing NKG2D-rae1 interaction between NKT and activated hepatic stellate cells in mice

(2014) Abhisek Mitra et al.   HEPATOLOGY

Cell-surface Vimentin: A mislocalized protein for isolating csVimentin+CD133−novel stem-like hepatocellular carcinoma cells expressing EMT markers

(2014) Abhisek Mitra et al.   INTERNATIONAL JOURNAL OF CANCER

Role of estrogen in hepatocellular carcinoma: is inflammation the key?

(2014) Liang Shi et al.   Journal of Translational Medicine

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1

(2013) Ling Yang et al.   GASTROENTEROLOGY

Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice

(2013) Ling Yang et al.   HEPATOLOGY

Cancer stem cells in the development of liver cancer

(2013) Taro Yamashita et al.   JOURNAL OF CLINICAL INVESTIGATION

Reciprocal regulation by TLR4 and TGF-β in tumor-initiating stem-like cells

(2013) Chia-Lin Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Adaptive immunity suppresses formation and progression of diethylnitrosamine-induced liver cancer

(2012) Carlo Schneider et al.   GUT

Signal Transducer and Activator of Transcription 5b (Stat5b) Serine 193 Is a Novel Cytokine-induced Phospho-regulatory Site That Is Constitutively Activated in Primary Hematopoietic Malignancies

(2012) Abhisek Mitra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DLK1 as a Potential Target against Cancer Stem/Progenitor Cells of Hepatocellular Carcinoma

(2012) X. Xu et al.   MOLECULAR CANCER THERAPEUTICS

Activation of an IL6 Inflammatory Loop Mediates Trastuzumab Resistance in HER2+ Breast Cancer by Expanding the Cancer Stem Cell Population

(2012) Hasan Korkaya et al.   MOLECULAR CELL

TGF-β and NF-κB signal pathway cross-talk is mediated through TAK1 and SMAD7 in a subset of head and neck cancers

(2012) C Freudlsperger et al.   ONCOGENE

Global cancer statistics

(2011) Ahmedin Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

STAT3 Is Necessary for Proliferation and Survival in Colon Cancer-Initiating Cells

(2011) L. Lin et al.   CANCER RESEARCH

Molecular Pathogenesis of Hepatocellular Carcinoma: Altering Transforming Growth Factor-β Signaling in Hepatocarcinogenesis

(2011) Ken Yamazaki et al.   DIGESTIVE DISEASES

Protease profiling of liver fibrosis reveals the ADAM metallopeptidase with thrombospondin type 1 motif, 1 as a central activator of transforming growth factor beta

(2011) Katia Bourd-Boittin et al.   HEPATOLOGY

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

miR-130b Promotes CD133+ Liver Tumor-Initiating Cell Growth and Self-Renewal via Tumor Protein 53-Induced Nuclear Protein 1

(2010) Stephanie Ma et al.   Cell Stem Cell

Role of IL-17 and Th17 Cells in Liver Diseases

(2010) Linda Hammerich et al.   Clinical & Developmental Immunology

Transforming growth factor-β adaptor, β2-spectrin, modulates cyclin dependent kinase 4 to reduce development of hepatocellular cancer

(2010) Hye Jung Baek et al.   HEPATOLOGY

Loss of transforming growth factor β adaptor protein β-2 spectrin leads to delayed liver regeneration in mice

(2010) Arun Thenappan et al.   HEPATOLOGY

Reduced transforming growth factor-β receptor II expression in hepatocellular carcinoma correlates with intrahepatic metastasis

(2010) Takao Mamiya et al.   LABORATORY INVESTIGATION

Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

(2009) Arun Thenappan et al.   HEPATOLOGY

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE

Targeting Interleukin 6 Signaling Suppresses Glioma Stem Cell Survival and Tumor Growth

(2009) Hui Wang et al.   STEM CELLS

Hepatocellular cancer arises from loss of transforming growth factor beta signaling adaptor protein embryonic liver fodrin through abnormal angiogenesis

(2008) Hye Jung Baek et al.   HEPATOLOGY

Expression and clinical significance of the stem cell marker CD133 in hepatocellular carcinoma

(2008) W. Song et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Progenitor/stem cells give rise to liver cancer due to aberrant TGF-  and IL-6 signaling

(2008) Y. Tang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA