TGR5 contributes to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic adenosine monophosphate/Gαs signaling

Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear  -H2AX possibly via iNOS induction

(2016) B. Jiang et al.   BIOSCIENCE REPORTS

Polycystic Liver Disease: The Benefits of Targeting cAMP

(2016) Nicholas F. Larusso et al.   Clinical Gastroenterology and Hepatology

Therapeutic potential of Takeda-G-protein-receptor-5 (TGR5) agonists. Hope or hype?

(2016) R. J. Hodge et al.   DIABETES OBESITY & METABOLISM

Membrane bile acid receptor TGR5 predicts good prognosis in ampullary adenocarcinoma patients with hyperbilirubinemia

(2016) Min-Chan Chen et al.   ONCOLOGY REPORTS

Generation of Homogenous Three-Dimensional Pancreatic Cancer Cell Spheroids Using an Improved Hanging Drop Technique

(2016) Matthew J. Ware et al.   TISSUE ENGINEERING PART C-METHODS

The bile acid receptor GPBAR1 (TGR5) is expressed in human gastric cancers and promotes epithelial-mesenchymal transition in gastric cancer cell lines

(2016) Adriana Carino et al.   Oncotarget

Somatostatin analogues improve health-related quality of life in polycystic liver disease: a pooled analysis of two randomised, placebo-controlled trials

(2015) M. K. Neijenhuis et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Upregulation of bile acid receptor TGR5 and nNOS in gastric myenteric plexus is responsible for delayed gastric emptying after chronic high-fat feeding in rats

(2015) Hui Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein–Coupled Bile Acid Receptors

(2015) Cheryl A. Brighton et al.   ENDOCRINOLOGY

TGR5 is essential for bile acid-dependent cholangiocyte proliferation in vivo and in vitro

(2015) Maria Reich et al.   GUT

Ursodeoxycholic acid inhibits hepatic cystogenesis in experimental models of polycystic liver disease

(2015) Patricia Munoz-Garrido et al.   JOURNAL OF HEPATOLOGY

Macrophage Activation by Ursolic and Oleanolic Acids during Mycobacterial Infection

(2015) Sonia López-García et al.   MOLECULES

HDAC6 Is Overexpressed in Cystic Cholangiocytes and Its Inhibition Reduces Cystogenesis

(2014) Sergio A. Gradilone et al.   AMERICAN JOURNAL OF PATHOLOGY

TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?

(2014) Verena Keitel et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The bile acid TGR5 membrane receptor: From basic research to clinical application

(2014) Henri Duboc et al.   DIGESTIVE AND LIVER DISEASE

Polycystic liver diseases: advanced insights into the molecular mechanisms

(2014) Maria J. Perugorria et al.   Nature Reviews Gastroenterology & Hepatology

Polycystic liver disease: ductal plate malformation and the primary cilium

(2014) Edgar S. Wills et al.   TRENDS IN MOLECULAR MEDICINE

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

(2013) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TGR5 in cholangiocytes

(2013) Verena Keitel et al.   CURRENT OPINION IN GASTROENTEROLOGY

The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

(2013) Dane D. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile acid receptors as targets for drug development

(2013) Frank G. Schaap et al.   Nature Reviews Gastroenterology & Hepatology

Expression of bile acid receptor TGR5 in gastric adenocarcinoma

(2012) Weibiao Cao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Chenodeoxycholic acid through a TGR5-dependent CREB signaling activation enhances Cyclin D1 expression and promotes human endometrial cancer cell proliferation

(2012) Ivan Casaburi et al.   CELL CYCLE

Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases

(2012) Tatyana V. Masyuk et al.   HEPATOLOGY

Identification of Tetrahydropyrido[4,3-d]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

(2012) David W. Piotrowski et al.   ACS Medicinal Chemistry Letters

Inhibition of Cdc25A Suppresses Hepato-renal Cystogenesis in Rodent Models of Polycystic Kidney and Liver Disease

(2011) Tatyana V. Masyuk et al.   GASTROENTEROLOGY

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

(2011) Y.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Simple Hanging Drop Cell Culture Protocol for Generation of 3D Spheroids

(2011) Ramsey Foty   Jove-Journal of Visualized Experiments

Randomized Clinical Trial of Long-Acting Somatostatin for Autosomal Dominant Polycystic Kidney and Liver Disease

(2010) M. C. Hogan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

(2009) J. Hong et al.   GUT

Discovery of 3-Aryl-4-isoxazolecarboxamides as TGR5 Receptor Agonists

(2009) Karen A. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hepatic Cystogenesis Is Associated with Abnormal Expression and Location of Ion Transporters and Water Channels in an Animal Model of Autosomal Recessive Polycystic Kidney Disease

(2008) Jesús M. Banales et al.   AMERICAN JOURNAL OF PATHOLOGY

The cAMP effectors Epac and protein kinase a (PKA) are involved in the hepatic cystogenesis of an animal model of autosomal recessive polycystic kidney disease (ARPKD)

(2008) Jesús M. Banales et al.   HEPATOLOGY