TGR5: Pathogenetic Role and/or Therapeutic Target in Fibrosing Cholangitis?

Systematic review: the epidemiology of the hepatobiliary manifestations in patients with inflammatory bowel disease

(2014) E. Gizard et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Loss of CD28 Expression by Liver-Infiltrating T Cells Contributes to Pathogenesis of Primary Sclerosing Cholangitis

(2014) Evaggelia Liaskou et al.   GASTROENTEROLOGY

Ciliary subcellular localization of TGR5 determines the cholangiocyte functional response to bile acid signaling

(2013) Anatoliy I. Masyuk et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

TGR5 in cholangiocytes

(2013) Verena Keitel et al.   CURRENT OPINION IN GASTROENTEROLOGY

CD8 T cells primed in the gut-associated lymphoid tissue induce immune-mediated cholangitis in mice

(2013) Daniel Seidel et al.   HEPATOLOGY

TGR5 signalling inhibits the production of pro-inflammatory cytokines byin vitrodifferentiated inflammatory and intestinal macrophages in Crohn's disease

(2013) Kazuaki Yoneno et al.   IMMUNOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

Update on primary sclerosing cholangitis

(2013) Tom H. Karlsen et al.   JOURNAL OF HEPATOLOGY

Bile acids PKA-dependently induce a switch of the IL-10/IL-12 ratio and reduce proinflammatory capability of human macrophages

(2013) Katrin Haselow et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Primary sclerosing cholangitis

(2013) Gideon M Hirschfield et al.   LANCET

The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon

(2013) J. B. J. Ward et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The biliary HCO3− umbrella

(2012) Ulrich Beuers et al.   CURRENT OPINION IN GASTROENTEROLOGY

Primary Sclerosing Cholangitis: New Approaches to Diagnosis, Surveillance and Treatment

(2012) Michael Trauner et al.   DIGESTIVE DISEASES

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

(2012) Farzad Alemi et al.   GASTROENTEROLOGY

Perspective: TGR5 (Gpbar-1) in liver physiology and disease

(2012) Verena Keitel et al.   Clinics and Research in Hepatology and Gastroenterology

Carcinogenicity of deoxycholate, a secondary bile acid

(2011) Carol Bernstein et al.   ARCHIVES OF TOXICOLOGY

Primary sclerosing cholangitis

(2011) Tom H. Karlsen et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Novel developments in IBD-related sclerosing cholangitis

(2011) C.Y. Ponsioen   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Pathogenesis of primary sclerosing cholangitis

(2011) Marion J. Pollheimer et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading

(2011) Thijs W.H. Pols et al.   Cell Metabolism

TGR5 in the Biliary Tree

(2011) Verena Keitel et al.   DIGESTIVE DISEASES

A biliary HCO3−umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes

(2011) Simon Hohenester et al.   HEPATOLOGY

The G-Protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor kappa light-chain enhancer of activated B cells (NF-κB) in mice

(2011) Yan-Dong Wang et al.   HEPATOLOGY

Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2 −/− (Abcb4 −/− ) mouse cholangiopathy model by promoting biliary HCO 3− output

(2011) Anna Baghdasaryan et al.   HEPATOLOGY

The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling

(2011) Tingting Li et al.   MOLECULAR ENDOCRINOLOGY

Association of bile acid receptor TGR5 variation and transit in health and lower functional gastrointestinal disorders

(2011) M. Camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis

(2011) Sabrina Cipriani et al.   PLoS One

The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes

(2010) Verena Keitel et al.   BIOLOGICAL CHEMISTRY

Cutting Edge Issues in Primary Sclerosing Cholangitis

(2010) Christopher L. Bowlus   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain

(2010) Verena Keitel et al.   GLIA

The biliary HCO3− umbrella: A unifying hypothesis on pathogenetic and therapeutic aspects of fibrosing cholangiopathies

(2010) Ulrich Beuers et al.   HEPATOLOGY

Gender-dependent effect of Gpbar1 genetic deletion on the metabolic profiles of diet-induced obese mice

(2010) Galya Vassileva et al.   JOURNAL OF ENDOCRINOLOGY

The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation

(2010) Thijs W.H. Pols et al.   JOURNAL OF HEPATOLOGY

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

(2010) D. P. Poole et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis

(2010) Johannes R. Hov et al.   PLoS One

TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis

(2009) Charles Thomas et al.   Cell Metabolism

Genome-Wide Association Analysis in Primary Sclerosing Cholangitis

(2009) Tom H. Karlsen et al.   GASTROENTEROLOGY

Role of a novel bile acid receptor TGR5 in the development of oesophageal adenocarcinoma

(2009) J. Hong et al.   GUT

The membrane-bound bile acid receptor TGR5 is localized in the epithelium of human gallbladders

(2009) Verena Keitel et al.   HEPATOLOGY

Diagnosis and management of primary sclerosing cholangitis

(2009) Roger Chapman et al.   HEPATOLOGY

Bicarbonate secretion of mouse cholangiocytes involves Na+-HCO3−cotransport in addition to Na+-independent Cl−/HCO3−exchange

(2009) Iker Uriarte et al.   HEPATOLOGY

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases

(2009)   JOURNAL OF HEPATOLOGY

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

A re-evaluation of the risk factors for the recurrence of primary sclerosing cholangitis in liver allografts

(2009) Edward Alabraba et al.   LIVER TRANSPLANTATION

Expression and function of the bile acid receptor TGR5 in Kupffer cells

(2008) Verena Keitel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Ae2a,b-Deficient Mice Develop Antimitochondrial Antibodies and Other Features Resembling Primary Biliary Cirrhosis

(2008) January T. Salas et al.   GASTROENTEROLOGY

Cholangiocarcinoma: Advances in pathogenesis, diagnosis, and treatment

(2008) Boris Blechacz et al.   HEPATOLOGY

Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure−Activity Relationships, and Molecular Modeling Studies

(2008) Hiroyuki Sato et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility

(2008) Andre Franke et al.   NATURE GENETICS

Etiopathogenesis of primary sclerosing cholangitis

(2008) Roger Chapman et al.   WORLD JOURNAL OF GASTROENTEROLOGY