Article
Reproductive Biology
Ling Zhou, Liqing Yao, Lin Dai, Honglan Zhu, Xue Ye, Shang Wang, Hongyan Cheng, Ruiqiong Ma, Huiping Liu, Heng Cui, Xiaohong Chang
Summary: The study identified distinct clinical characteristics of Chinese patients with ovarian endometrioid carcinoma (EC) and clear cell carcinoma (CCC), showing that EC patients tend to be younger while CCC has two peaks in disease onset. EC patients are more likely to have concurrent endometrial cancer and express estrogen and progesterone receptors, with more patients in a premenopausal state. The study also found that in the pure group, the correlation with endometriosis is associated with worse outcomes, while mixed endometrioid histology in mixed cancer patients is linked to better survival rates.
JOURNAL OF OVARIAN RESEARCH
(2021)
Article
Oncology
Alejandro Gallego, Marta Mendiola, Barbara Hernando, Alberto Berjon, Alice Cadiz, Blas Chaves-Urbano, Victoria Heredia-Soto, Emanuela Spagnolo, Alicia Hernandez Gutierrez, David Hardisson, Geoff Macintyre, Andres Redondo, Maria Jose Garcia
Summary: This study found that patients with endometrioid and clear cell ovarian cancer who had moderate to high levels of CD8+ and CD3+ intraepithelial tumor infiltrating lymphocytes had longer overall survival. Higher expression of intratumoral CD3+ and CD8+ tumor infiltrating lymphocytes also showed an improved outcome in endometrioid ovarian cancer. However, systemic inflammation did not have a prognostic impact in these histologic subtypes.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2022)
Review
Oncology
Oscar G. W. Wong, Jing Li, Annie N. Y. Cheung
Summary: Ovarian clear cell carcinoma (OCCC) is an important type of ovarian cancer with higher prevalence and resistance to chemotherapy in Asians. OCCC has genetic defects rendering it vulnerable to DNA damage response-targeting therapy, particularly highlighted by loss-of-function mutations in ARID1A, making it sensitive to PARP inhibitors. Progress in utilizing DDR deficiency in OCCC treatment is promising but lagging in clinical application.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Ertugrul Bayram, Ghanim Khatib, Burak Guney, Emine Kilicbagir, Huru Rabia Gulec, Ibrahim Boga, Semra Paydas
Summary: Patients with metastatic ovarian cancer who develop resistance to standard therapy need alternative treatment options. In this case, a patient with mixed-type ovarian cancer had initial success with combination therapy but experienced disease progression. Molecular analysis revealed a PIK3CA mutation, and treatment with a selective PI3K inhibitor achieved complete remission for over two years. This case demonstrates the utility of the inhibitor in managing mixed-type ovarian cancer.
Article
Multidisciplinary Sciences
Nancy Guo, Aijun Yang, Fabiha Binte Farooq, Shreena Kalaria, Elena Moss, Lindsay DeVorkin, Mary Lesperance, Francois Benard, Don Wilson, Anna V. Tinker, Farouk S. Nathoo, Phineas T. Hamilton, Julian J. Lum
Summary: Unlike other epithelial ovarian carcinomas, clear cell ovarian carcinoma (CCOC) has a poor response to therapy. The expression of Carbonic anhydrase IX (CAIX) and CD8 + tumor-infiltrating lymphocytes (TILs) have distinct effects on the prognosis of CCOC patients. This study evaluates the relationship between CAIX, CD8, and survival in CCOC using imaging, transcriptome profiling, and histological analysis. The results suggest that hypoxia may contribute to immune exclusion in CCOC, primarily mediated by effects in the stromal regions.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Shaan Dudani, Guillermo de Velasco, J. Connor Wells, Chun Loo Gan, Frede Donskov, Camillo Porta, Anna Fraccon, Felice Pasini, Jae Lyun Lee, Aaron Hansen, Georg A. Bjarnason, Benoit Beuselinck, Sumanta K. Pal, Takeshi Yuasa, Nils Kroeger, Ravindran Kanesvaran, M. Neil Reaume, Christina Canil, Toni K. Choueiri, Daniel Y. C. Heng
Summary: This study found that patterns of metastasis vary between histologic subtypes of metastatic RCC and are associated with overall survival. The data highlight the clinical and biological variability between histologic subtypes and suggest that patterns of metastasis may reflect differences in underlying disease biology. Further research is encouraged to investigate differences in immune, molecular, and genetic profiles between metastatic sites and histologic subtypes.
Article
Immunology
Huiyang Yuan, Xin Qin, Jing Wang, Qingya Yang, Yidong Fan, Dawei Xu
Summary: This study identified the clinical implications of cuproptosis in clear cell renal cell carcinoma (ccRCC) and constructed a gene signature score system (CuAGS-13) that can predict patients' survival, recurrence, and response to treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Adam J. Ferrari, Priyanka Rawat, Hannah S. Rendulich, Akshaya Annapragada, Yasuto Kinose, Xiaoming Zhang, Kyle Devins, Anna Budina, Robert B. Scharpf, Marilyn A. Mitchell, Janos L. Tanyi, Mark A. Morgan, Lauren E. Schwartz, T. Rinda Soong, Victor E. Velculescu, Ronny Drapkin
Summary: Epigenetic aberrations, specifically the loss of histone H2B monoubiquitylation (H2Bub1), are associated with the development and progression of clear cell ovarian carcinoma (CCOC). The study identified hypermethylation of RNF40 as a likely mechanism underlying the loss of H2Bub1 in CCOC. Additionally, depletion of H2Bub1 was found to promote cell proliferation and clonogenicity in an endometriosis cell line.
Article
Oncology
Michael-John Devilin, Rowan Miller, Florian Laforets, Panoraia Kotantaki, Dale W. Garsed, Rebecca Kristeleit, David D. Bowtell, Jacqueline McDermott, Eleni Maniati, Frances R. Balkwill
Summary: The tumor microenvironment (TME) of clear-cell ovarian cancer (CCOC) was analyzed in this study, revealing differences in immune cell populations, collagen matrix, and cytokine expression between different areas of the tumor. Advanced CCOC showed increased fibroblasts and a more complex collagen matrix compared to early CCOC. Differences in immune cell populations, collagen matrix, and cytokine expression were also observed between different genetic subtypes of CCOC. Increased infiltration of specific T cell subpopulations was associated with decreased overall survival.
CANCER IMMUNOLOGY RESEARCH
(2022)
Editorial Material
Oncology
Stephanie Lheureux
Summary: The diagnosis of clear cell ovarian cancer relies on expert histopathology review. Further characterization through deep genomic and transcriptomic analyses can identify different subgroups. International collaboration is required to define the clinical impact and therapy opportunities in these specific subclassifications.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Junhwan Kim, Se Ik Kim, Nae Ry Kim, Hyojin Kim, Hee Seung Kim, Hyun Hoon Chung, Jae-Weon Kim, Cheol Lee, Maria Lee
Summary: This study investigated the prognostic significance of L1 cell-adhesion molecule (L1CAM), β-catenin, and programmed death-ligand 1 (PD-L1) in endometrial cancer (EC) patients, with a focus on the p53 wild-type subgroup. The results showed that L1CAM positivity was associated with poor prognosis in EC and increased the risk of recurrence in the p53 wild-type subgroup.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
Shuangfeng Chen, Yuebo Li, Lili Qian, Sisi Deng, Luwen Liu, Weihua Xiao, Ying Zhou
Summary: Ovarian cancer, especially endometrioid ovarian cancer, is closely related to endometriosis and Lynch syndrome, with dysbiosis of the female reproductive tract microbiota potentially playing a role in its pathogenesis. Dysregulation of the microenvironment and accumulation of mutations are stimulatory factors in the progression of endometrioid ovarian carcinoma. The study of molecular subtypes of endometrioid ovarian cancer is crucial for predicting prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Tamaki Tanaka, Kazuhiro Takehara, Natsumi Yamashita, Mika Okazawa-Sakai, Kazuya Kuraoka, Norihiro Teramoto, Kenichi Taguchi, Katsushige Yamashiro, Hidenori Kato, Tomoya Mizunoe, Rie Suzuki, Dan Yamamoto, Arisa Ueki, Toshiaki Saito
Summary: The study aimed to clarify the frequency of deficient mismatch repair (dMMR) in Japanese ovarian cancer patients by examining microsatellite instability (MSI) status and immunohistochemistry (IHC) subtypes. Results showed that endometrioid carcinoma (EMC) patients had a higher frequency of dMMR compared to clear cell carcinoma (CCC) and mixed types. Prognostic factors identified included advanced stage and histological type.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Pathology
Jiani Qu, Jing Yu, Siyuan Zhong, Wenchao Wang, Qingping Wang, Bin Du
Summary: This study found clear cell glands in the endometrioid cysts of the ovary. The association between these clear cell glands and clear cell borderline tumors and clear cell carcinoma was explored. Clinicopathological features, immunohistochemistry, and whole-exome sequencing analysis were conducted to investigate the characteristics and changes of these tumors. In conclusion, the clear cell glands in the endometrioid cysts of the ovary were associated with clear cell carcinoma.
Review
Biochemistry & Molecular Biology
Alexey Zamaraev, Pavel Volik, Gennady T. Sukhikh, Gelina S. Kopeina, Boris Zhivotovsky
Summary: Long non-coding RNAs (lncRNAs) play a significant role in tumor progression, impacting cellular processes and playing a key role in ovarian cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Obstetrics & Gynecology
Anne M. Kolehmainen, Annukka M. Pasanen, Riitta L. Koivisto-Korander, Ralf C. Butzow, Mikko J. Loukovaara
Summary: This study assessed the capability of molecular classification to predict the stage of endometrial carcinoma, with POLE EDM independently predicting early stage disease. Despite p53 abn not being an independent predictor of advanced disease, its association with uterine risk factors could be useful in deciding the type of staging surgery.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2021)
Article
Oncology
Mikko Loukovaara, Annukka Pasanen, Ralf Butzow
Summary: The study suggests that MMR protein and MLH1 methylation status can predict the response to adjuvant therapy in endometrial cancer. Whole pelvic radiotherapy and chemotherapy combined with radiotherapy were associated with improved disease-specific survival in certain subgroups, while they were associated with poor disease-specific survival in other subgroups.
Article
Pathology
Iiris Ukkola, Pirjo Nummela, Annukka Pasanen, Mia Kero, Anna Lepisto, Soili Kytola, Ralf Butzow, Ari Ristimaki
Summary: Universal testing of microsatellite instability (MSI) is recommended for colorectal cancer (CRC) and endometrial cancer (EC) to screen for Lynch syndrome and to aid in assessing prognosis and optimal treatment. The Idylla MSI test offers a sensitive and specific method for CRC diagnostics but is less sensitive in EC samples, especially in the case of MSH6 deficiency.
Article
Multidisciplinary Sciences
Davide G. Berta, Heli Kuisma, Niko Valimaki, Maritta Raisanen, Maija Jantti, Annukka Pasanen, Auli Karhu, Jaana Kaukomaa, Aurora Taira, Tatiana Cajuso, Sanna Nieminen, Rosa-Maria Penttinen, Saija Ahonen, Rainer Lehtonen, Miika Mehine, Pia Vahteristo, Jyrki Jalkanen, Biswajyoti Sahu, Janne Ravantti, Netta Makinen, Kristiina Rajamaki, Kimmo Palin, Jussi Taipale, Oskari Heikinheimo, Ralf Butzow, Eevi Kaasinen, Lauri A. Aaltonen
Summary: One in four women suffer from uterine leiomyomas (ULs) at some point in premenopausal life, which can cause excessive bleeding, pain, and infertility. Recent research identified mutations in genes encoding members of the SRCAP histone-loading complex as potential drivers of UL, indicating a potential mechanism of tumorigenesis involving epigenetic instability caused by deficient H2A.Z deposition.
Article
Multidisciplinary Sciences
Annukka Pasanen, Mikko Loukovaara, Terhi Ahvenainen, Pia Vahteristo, Ralf Butzow
Summary: The study assessed the prognostic impact of conventional risk factors and ancillary biomarkers in the two largest ProMisE molecular subgroups of endometrial carcinoma. They found that grade of differentiation and p16 hyperexpression have a stronger prognostic impact in endometrial carcinomas with no specific molecular profile compared to mismatch repair deficient endometrial carcinomas. These differential impacts of risk factors need to be taken into account when developing new molecular class-integrated risk stratification algorithms for endometrial carcinoma.
Article
Multidisciplinary Sciences
Liisu Saavalainen, Heini Lassus, Anna But, Mika Gissler, Oskari Heikinheimo, Eero Pukkala
Summary: In Finland, the risk of extraovarian clear cell cancers in women with surgically diagnosed endometriosis is similar to that in the general population and is not affected by the type of endometriosis. The incidence of clear cell cancer in specific sites is also not increased.
Article
Multidisciplinary Sciences
Heli Kuisma, Simona Bramante, Kristiina Rajamaki, Lauri J. Sipila, Eevi Kaasinen, Jaana Kaukomaa, Kimmo Palin, Netta Makinen, Jari Sjoberg, Nanna Sarvilinna, Jussi Taipale, Liisa Kauppi, Manuela Tumiati, Antti Hassinen, Janne Pitkaniemi, Jyrki Jalkanen, Sanna Heikkinen, Annukka Pasanen, Oskari Heikinheimo, Ralf Butzow, Niko Valimaki, Lauri A. Aaltonen
Summary: This study reveals an association between parity and chromosomal damage in uterine leiomyomas, suggesting that mechanical forces in a constrained cellular environment may contribute to tumor development without evidence of progression to malignancy.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Mikko Loukovaara, Annukka Pasanen, Ralf Butzow
Summary: In this retrospective study, the aggressiveness of MMR deficient endometrial carcinomas was examined. MMR deficiency was associated with poor disease-specific survival and increased risk of cancer-related death. The findings highlight the need for improved triage to adjuvant therapy and new therapeutic approaches in MMR deficient endometrial carcinomas.
Article
Oncology
Piret Soovares, Annukka Pasanen, Jonna Simila-Maarala, Ralf Butzow, Heini Lassus
Summary: The study revealed that tumor grade and disease stage are independent clinical prognostic factors in EnOC. Good-prognosis markers (PR, ER, beta-catenin, and vimentin) were associated with favorable outcomes, while poor-prognosis markers (p53, p16, and L1CAM) were related to aggressive disease characteristics and poor survival.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Jonna Simila-Maarala, Piret Soovares, Annukka Pasanen, Terhi Ahvenainen, Pia Vahteristo, Ralf Butzow, Heini Lassus
Summary: This study evaluated and compared the molecular classification of clear cell carcinoma and endometrioid ovarian carcinoma in a large series of samples. The results showed that the TCGA molecular classification was associated with patient prognosis, and the difference in prognosis between the molecular groups was more pronounced in clear cell carcinoma.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Christian Marth, Miguel Henriques Abreu, Klaus Kaae Andersen, Karoliina M. Aro, Maria de Lurdes Batarda, Dorry Boll, Anne Weng Ekmann-Gade, Ulla-Maija Haltia, Jesper Hansen, Ala Jabri Haug, Claus Hogdall, Jacob Korach, Heini Lassus, Kristina Lindemann, Els Van Nieuwenhuysen, Petronella B. Ottevanger, Stephan Polterauer, Tine Henrichsen Schnack
Summary: This study aimed to describe the treatment strategies and outcomes for women with newly diagnosed advanced high-grade serous or endometrioid ovarian cancer. The results showed that the use of bevacizumab and a deleterious BRCA status improved survival in this population.
Article
Oncology
Astrid Murumagi, Daniela Ungureanu, Suleiman Khan, Mariliina Arjama, Katja Valimaki, Aleksandr Ianevski, Philipp Ianevski, Rebecka Bergstrom, Alice Dini, Anna Kanerva, Riitta Koivisto-Korander, Johanna Tapper, Heini Lassus, Mikko Loukovaara, Andrus Magi, Akira Hirasawa, Daisuke Aoki, Vilja Pietiainen, Teijo Pellinen, Ralf Butzow, Tero Aittokallio, Olli Kallioniemi
Summary: Efforts are being made to develop new therapies for aggressive high-grade serous ovarian cancers (HGSOCs), but the understanding of treatment options for low-grade (LGSOC) or mucinous (MUCOC) ovarian malignancies is lacking. A functional precision oncology (fPO) strategy combining drug testing, genomic profiling and transcriptomic profiling was used to study epithelial ovarian cancers (EOC). Different drug response profiles were observed among HGSOC, LGSOC, and MUCOC PDCs, with LGSOCs responding better to targeted inhibitors. Specific drug responses were identified for each subtype, with potential for individualized therapies in the future.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Sanna Pikkusaari, Manuela Tumiati, Anni Virtanen, Jaana Oikkonen, Yilin Li, Fernando Perez-Villatoro, Taru Muranen, Matilda Salko, Kaisa Huhtinen, Anna Kanerva, Heidi Koskela, Johanna Tapper, Riitta Koivisto-Korander, Titta Joutsiniemi, Ulla-Maija Haltia, Heini Lassus, Sampsa Hautaniemi, Anniina Farkkila, Johanna Hynninen, Sakari Hietanen, Olli Carpen, Liisa Kauppi
Summary: A clinically feasible assay was developed to identify HR-deficient tumors in high-grade serous ovarian cancers. The assay predicted clinical outcomes and helped determine which patients were most likely to benefit from platinum-based chemotherapy and PARP inhibitors.
CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
A. Kolehmainen, A. Pasanen, R. Koivisto-Korander, R. Butzow, M. Loukovaara
Summary: A risk-scoring model was developed to predict post-recurrence survival in patients with endometrial carcinoma. The model identified risk factors and assigned risk scores based on odds ratios. The model showed acceptable to excellent accuracy in predicting survival.
Article
Oncology
Mikko Loukovaara, Ralf Buetzow, Synnove Staff, Minna Maenpaa, Maria Faltinova, Heini Lassus, Olga Veijalainen, Maiju Gronvall, Leila Vaalavirta, Elina Kuikka, Marjut Haataja, Elina Urpilainen, Marja Simojoki, Maarit Anttila, Annika Auranen
Summary: This study aims to investigate the value of molecular classification in determining the adjuvant therapies for high-intermediate risk and early-stage high-risk endometrial carcinoma. The study hypothesis is that whole pelvic radiotherapy may improve outcomes for MMRd or NSMP high-intermediate risk carcinomas, while chemoradiotherapy may be more beneficial for early-stage high-risk p53abn and nonendometrioid carcinomas compared to chemotherapy alone. POLE ultramutated carcinomas with high-intermediate or high-risk clinicopathologic features are speculated to have a favorable prognosis without any adjuvant therapy.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2023)